Detailed information of TA system TA117803

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelB(antitoxin)
• Location: 1597334..1597946
• Replicon: chromosome
• Accession: NZ_CP035448
• Organism: Streptococcus pyogenes strain emm70

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: ETT51_RS08090
• Protein ID: WP_038432559.1
• Coordinates: 1597611..1597946 (+)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: Q5X9X9
• Locus tag: ETT51_RS08085
• Protein ID: WP_002988079.1
• Coordinates: 1597334..1597621 (+)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ETT51_RS08060	1592526..1593509	-	984	WP_011529001.1	tagatose-bisphosphate aldolase	-
ETT51_RS08065	1593513..1594442	-	930	WP_020837785.1	tagatose-6-phosphate kinase	-
ETT51_RS08070	1594488..1595003	-	516	WP_002991700.1	galactose-6-phosphate isomerase subunit LacB	-
ETT51_RS08075	1595038..1595466	-	429	WP_002991702.1	galactose-6-phosphate isomerase subunit LacA	-
ETT51_RS08080	1595911..1596684	+	774	WP_011285171.1	DeoR/GlpR family DNA-binding transcription regulator	-
ETT51_RS08085	1597334..1597621	+	288	WP_002988079.1	DNA-damage-inducible protein J	Antitoxin
ETT51_RS08090	1597611..1597946	+	336	WP_038432559.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
ETT51_RS09245	1598098..1598568	+	471	Protein_1520	tyrosine-type recombinase/integrase family protein	-
ETT51_RS09250	1598930..1599079	+	150	WP_011285175.1	integrase	-
ETT51_RS08110	1599211..1599603	-	393	WP_002982716.1	30S ribosomal protein S9	-
ETT51_RS08115	1599624..1600070	-	447	WP_002982710.1	50S ribosomal protein L13	-
ETT51_RS08120	1600288..1600494	-	207	WP_002982695.1	helix-turn-helix transcriptional regulator	-
ETT51_RS08125	1600491..1600997	-	507	WP_063632519.1	hypothetical protein	-
ETT51_RS08130	1601133..1601993	-	861	WP_002982687.1	DegV family protein	-
ETT51_RS08135	1602090..1602608	-	519	WP_011055010.1	NYN domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (7-107)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 13159.91 Da
• Isoelectric Point: 5.2144

>T117803 WP_038432559.1 NZ_CP035448:1597611-1597946 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIISDIEKLEVFPEVGFDADEKYGSKISHYHSTKGYTLSKD
YIILYHIEGEENRVVIDYLLPTQSDYIKLFK

Nucleotide

• Length: 336 bp

>T117803 NZ_CP035448:1597611-1597946 [Streptococcus pyogenes]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCTCA
AAACTACTCCTCAACATCAGGTCAGCGTAAAATGGAGCAAATCATTAGCGACATAGAAAAACTCGAGGTTTTCCCAGAAG
TTGGTTTTGATGCCGATGAAAAATATGGTTCAAAAATCAGTCATTATCACAGCACTAAAGGTTATACCTTAAGTAAAGAT
TATATTATCCTATACCATATCGAGGGGGAAGAAAATAGGGTCGTTATTGATTACTTGCTTCCTACTCAAAGCGACTATAT
AAAGTTATTCAAATAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10934.56 Da
• Isoelectric Point: 5.2318

>AT117803 WP_002988079.1 NZ_CP035448:1597334-1597621 [Streptococcus pyogenes]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Nucleotide

• Length: 288 bp

>AT117803 NZ_CP035448:1597334-1597621 [Streptococcus pyogenes]
ATGACTACAGTAAAAAAAAACAGAGCGGTTACCTTTCAAGCTAACAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCTGAAATCAACAAAAATATTGAGGATGTTCGTCAA
GGGAAGTTTTATACCTCTGAAGAAGTGAGGGCTGAACTTGGACTATAA

Structures

Antitoxin

• AlphaFold DB: A0A4U7GX94