Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 1559122..1559734 Replicon chromosome
Accession NZ_CP035447
Organism Streptococcus pyogenes strain emm97.1

Toxin (Protein)


Gene name parE Uniprot ID Q5X9X8
Locus tag ETT52_RS07970 Protein ID WP_011018227.1
Coordinates 1559399..1559734 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q5X9X9
Locus tag ETT52_RS07965 Protein ID WP_002988079.1
Coordinates 1559122..1559409 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ETT52_RS07940 1554300..1555283 - 984 WP_002982755.1 tagatose-bisphosphate aldolase -
ETT52_RS07945 1555287..1556216 - 930 WP_136026369.1 tagatose-6-phosphate kinase -
ETT52_RS07950 1556264..1556779 - 516 WP_014407849.1 galactose-6-phosphate isomerase subunit LacB -
ETT52_RS07955 1556814..1557242 - 429 WP_136026368.1 galactose-6-phosphate isomerase subunit LacA -
ETT52_RS07960 1557688..1558461 + 774 WP_011285171.1 DeoR/GlpR family DNA-binding transcription regulator -
ETT52_RS07965 1559122..1559409 + 288 WP_002988079.1 DNA-damage-inducible protein J Antitoxin
ETT52_RS07970 1559399..1559734 + 336 WP_011018227.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ETT52_RS07975 1559886..1560068 + 183 WP_011285716.1 integrase -
ETT52_RS07980 1560471..1560838 + 368 Protein_1460 tyrosine-type recombinase/integrase -
ETT52_RS07985 1560958..1561350 - 393 WP_002982716.1 30S ribosomal protein S9 -
ETT52_RS07990 1561371..1561817 - 447 WP_002982710.1 50S ribosomal protein L13 -
ETT52_RS07995 1562035..1562241 - 207 WP_136026367.1 helix-turn-helix transcriptional regulator -
ETT52_RS08000 1562238..1562936 - 699 WP_168388530.1 hypothetical protein -
ETT52_RS08005 1563072..1563932 - 861 WP_011529009.1 DegV family protein -
ETT52_RS08010 1564029..1564547 - 519 WP_002982682.1 NYN domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-105)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 13171.97 Da        Isoelectric Point: 5.2144

>T117802 WP_011018227.1 NZ_CP035447:1559399-1559734 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIISDIEKLEVFPEVGFDADEKYGSKIIHYHSTKGYTLSKD
YIVLYHIEGEENRVVIDYLLPTQSDYIKLFK

Download         Length: 336 bp

>T117802 NZ_CP035447:1559399-1559734 [Streptococcus pyogenes]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCTCA
AAACTATTCCTCAACATCAGGTCAGCGTAAAATGGAGCAAATCATTAGCGACATAGAAAAACTCGAGGTTTTCCCAGAAG
TTGGTTTTGATGCCGATGAAAAATATGGTTCAAAAATCATCCATTATCACAGCACTAAAGGTTATACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAGGGGGAAGAAAATAGGGTCGTTATTGATTACTTGCTTCCTACTCAAAGCGACTATAT
AAAGTTATTCAAATAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10934.56 Da        Isoelectric Point: 5.2318

>AT117802 WP_002988079.1 NZ_CP035447:1559122-1559409 [Streptococcus pyogenes]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Download         Length: 288 bp

>AT117802 NZ_CP035447:1559122-1559409 [Streptococcus pyogenes]
ATGACTACAGTAAAAAAAAACAGAGCGGTTACCTTTCAAGCTAATAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCTGAAATCAACAAAAATATTGAGGATGTTCGTCAA
GGGAAGTTTTATACCTCTGAAGAAGTGAGGGCTGAACTTGGACTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7Z2QKE7

Antitoxin

Source ID Structure
AlphaFold DB A0A4U7GX94

References