Detailed information of TA system TA117801

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelB(antitoxin)
• Location: 1507303..1507915
• Replicon: chromosome
• Accession: NZ_CP035446
• Organism: Streptococcus pyogenes strain emm68.2

Toxin (Protein)

• Gene name: parE
• Uniprot ID: Q1JJZ2
• Locus tag: ETT53_RS07625
• Protein ID: WP_002988077.1
• Coordinates: 1507580..1507915 (+)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: Q5X9X9
• Locus tag: ETT53_RS07620
• Protein ID: WP_002988079.1
• Coordinates: 1507303..1507590 (+)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ETT53_RS07595	1502492..1503475	-	984	WP_014635708.1	tagatose-bisphosphate aldolase	-
ETT53_RS07600	1503479..1504408	-	930	WP_002982751.1	tagatose-6-phosphate kinase	-
ETT53_RS07605	1504456..1504971	-	516	WP_063629194.1	galactose-6-phosphate isomerase subunit LacB	-
ETT53_RS07610	1505006..1505434	-	429	WP_002982747.1	galactose-6-phosphate isomerase subunit LacA	-
ETT53_RS07615	1505880..1506653	+	774	WP_002982738.1	DeoR/GlpR family DNA-binding transcription regulator	-
ETT53_RS07620	1507303..1507590	+	288	WP_002988079.1	DNA-damage-inducible protein J	Antitoxin
ETT53_RS07625	1507580..1507915	+	336	WP_002988077.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
ETT53_RS08835	1508067..1508537	+	471	WP_002988074.1	integrase	-
ETT53_RS08840	1508500..1508862	+	363	WP_186786831.1	tyrosine-type recombinase/integrase	-
ETT53_RS08845	1508898..1509047	+	150	WP_011285175.1	integrase	-
ETT53_RS07635	1509180..1509572	-	393	WP_002982716.1	30S ribosomal protein S9	-
ETT53_RS07640	1509593..1510039	-	447	WP_002982710.1	50S ribosomal protein L13	-
ETT53_RS07645	1510257..1510463	-	207	WP_002982695.1	helix-turn-helix transcriptional regulator	-
ETT53_RS07650	1510460..1511158	-	699	WP_164972302.1	hypothetical protein	-
ETT53_RS07655	1511294..1512154	-	861	WP_129321376.1	DegV family protein	-
ETT53_RS07660	1512251..1512769	-	519	WP_002982682.1	NYN domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-105)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 13117.83 Da
• Isoelectric Point: 5.2144

>T117801 WP_002988077.1 NZ_CP035446:1507580-1507915 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIISDIEKLEVFPEVGFDADEKYGSKISHYHSTKGYTLSKD
YIVLYHIEGEENRVAIDYLLPTQSDYIKLFK

Nucleotide

• Length: 336 bp

>T117801 NZ_CP035446:1507580-1507915 [Streptococcus pyogenes]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCTCA
AAACTACTCCTCAACATCAGGTCAGCGTAAAATGGAGCAAATCATTAGCGACATAGAAAAACTCGAGGTTTTCCCAGAAG
TTGGTTTTGATGCCGATGAAAAATATGGTTCAAAAATCAGCCATTATCACAGCACTAAAGGTTACACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAGGGGGAAGAAAATAGGGTCGCTATTGATTACTTGCTTCCTACTCAAAGCGACTATAT
AAAGTTATTCAAATAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10934.56 Da
• Isoelectric Point: 5.2318

>AT117801 WP_002988079.1 NZ_CP035446:1507303-1507590 [Streptococcus pyogenes]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Nucleotide

• Length: 288 bp

>AT117801 NZ_CP035446:1507303-1507590 [Streptococcus pyogenes]
ATGACTACAGTAAAAAAAAACAGAGCGGTTACCTTTCAAGCTAATAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCTGAAATCAACAAAAATATTGAGGACGTTCGTCAA
GGGAAGTTTTATACCTCTGAAGAAGTGAGGGCTGAACTTGGACTATAA

Structures

Toxin

• AlphaFold DB: A0A660A236

Antitoxin

• AlphaFold DB: A0A4U7GX94