Detailed information of TA system TA117800

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelB(antitoxin)
• Location: 1518989..1519601
• Replicon: chromosome
• Accession: NZ_CP035445
• Organism: Streptococcus pyogenes strain emm92

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: ETT54_RS07680
• Protein ID: WP_136098156.1
• Coordinates: 1519266..1519601 (+)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: Q5X9X9
• Locus tag: ETT54_RS07675
• Protein ID: WP_002988079.1
• Coordinates: 1518989..1519276 (+)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ETT54_RS07650	1514180..1515163	-	984	WP_014407847.1	tagatose-bisphosphate aldolase	-
ETT54_RS07655	1515167..1516096	-	930	WP_115354284.1	tagatose-6-phosphate kinase	-
ETT54_RS07660	1516142..1516657	-	516	WP_014407849.1	galactose-6-phosphate isomerase subunit LacB	-
ETT54_RS07665	1516692..1517120	-	429	WP_011529004.1	galactose-6-phosphate isomerase subunit LacA	-
ETT54_RS07670	1517566..1518339	+	774	WP_002993783.1	DeoR/GlpR family DNA-binding transcription regulator	-
ETT54_RS07675	1518989..1519276	+	288	WP_002988079.1	DNA-damage-inducible protein J	Antitoxin
ETT54_RS07680	1519266..1519601	+	336	WP_136098156.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
ETT54_RS08865	1519752..1520189	+	438	Protein_1420	integrase	-
ETT54_RS07690	1520337..1520735	+	399	WP_181879099.1	tyrosine-type recombinase/integrase	-
ETT54_RS07695	1520855..1521247	-	393	WP_002982716.1	30S ribosomal protein S9	-
ETT54_RS07700	1521268..1521714	-	447	WP_002982710.1	50S ribosomal protein L13	-
ETT54_RS07705	1521932..1522138	-	207	WP_011285176.1	helix-turn-helix transcriptional regulator	-
ETT54_RS07710	1522135..1522833	-	699	WP_168429786.1	hypothetical protein	-
ETT54_RS07715	1522969..1523829	-	861	WP_136098158.1	DegV family protein	-
ETT54_RS07720	1523926..1524444	-	519	WP_136098159.1	NYN domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (7-104)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 13145.89 Da
• Isoelectric Point: 5.6809

>T117800 WP_136098156.1 NZ_CP035445:1519266-1519601 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIISDIEKLEVFPEVGFDADEKYGSKISHYHSTKGYTLSKD
YIVLYHIEGEENRAVIDYLLPTRSDYIKLFK

Nucleotide

• Length: 336 bp

>T117800 NZ_CP035445:1519266-1519601 [Streptococcus pyogenes]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCTCA
AAACTATTCCTCAACATCAGGTCAGCGTAAAATGGAGCAAATCATTAGCGACATAGAAAAACTCGAGGTTTTCCCAGAAG
TTGGTTTTGATGCCGATGAAAAATATGGTTCAAAAATCAGCCATTATCACAGCACTAAAGGTTACACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAGGGGGAAGAAAATAGGGCCGTTATTGATTACTTGCTTCCTACTCGAAGCGACTATAT
AAAGTTATTCAAATAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10934.56 Da
• Isoelectric Point: 5.2318

>AT117800 WP_002988079.1 NZ_CP035445:1518989-1519276 [Streptococcus pyogenes]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Nucleotide

• Length: 288 bp

>AT117800 NZ_CP035445:1518989-1519276 [Streptococcus pyogenes]
ATGACTACAGTAAAAAAAAACAGAGCGGTTACCTTTCAAGCTAATAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCTGAAATCAACAAAAATATTGAGGATGTTCGTCAA
GGGAAGTTTTATACCTCTGAAGAAGTGAGGGCTGAACTTGGACTATAA

Structures

Antitoxin

• AlphaFold DB: A0A4U7GX94