Detailed information of TA system TA117799

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelB(antitoxin)
• Location: 1530665..1531277
• Replicon: chromosome
• Accession: NZ_CP035444
• Organism: Streptococcus pyogenes strain emm90.5

Toxin (Protein)

• Gene name: parE
• Uniprot ID: Q5X9X8
• Locus tag: ETT55_RS07700
• Protein ID: WP_011018227.1
• Coordinates: 1530942..1531277 (+)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: Q5X9X9
• Locus tag: ETT55_RS07695
• Protein ID: WP_002988079.1
• Coordinates: 1530665..1530952 (+)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ETT55_RS07670	1525856..1526839	-	984	WP_030126263.1	tagatose-bisphosphate aldolase	-
ETT55_RS07675	1526843..1527772	-	930	WP_136021684.1	tagatose-6-phosphate kinase	-
ETT55_RS07680	1527818..1528333	-	516	WP_014407849.1	galactose-6-phosphate isomerase subunit LacB	-
ETT55_RS07685	1528368..1528796	-	429	WP_011529004.1	galactose-6-phosphate isomerase subunit LacA	-
ETT55_RS07690	1529242..1530015	+	774	WP_002993783.1	DeoR/GlpR family DNA-binding transcription regulator	-
ETT55_RS07695	1530665..1530952	+	288	WP_002988079.1	DNA-damage-inducible protein J	Antitoxin
ETT55_RS07700	1530942..1531277	+	336	WP_011018227.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
ETT55_RS07705	1531429..1531899	+	471	WP_136021685.1	site-specific integrase	-
ETT55_RS07710	1532043..1532363	+	321	WP_082243205.1	tyrosine-type recombinase/integrase	-
ETT55_RS07715	1532531..1532923	-	393	WP_136021686.1	30S ribosomal protein S9	-
ETT55_RS07720	1532944..1533390	-	447	WP_002982710.1	50S ribosomal protein L13	-
ETT55_RS07725	1533608..1533814	-	207	WP_011285176.1	helix-turn-helix transcriptional regulator	-
ETT55_RS07730	1533811..1534509	-	699	WP_030126259.1	hypothetical protein	-
ETT55_RS07735	1534645..1535505	-	861	WP_030127324.1	DegV family protein	-
ETT55_RS07740	1535602..1536120	-	519	WP_002982682.1	NYN domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-105)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 13171.97 Da
• Isoelectric Point: 5.2144

>T117799 WP_011018227.1 NZ_CP035444:1530942-1531277 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIISDIEKLEVFPEVGFDADEKYGSKIIHYHSTKGYTLSKD
YIVLYHIEGEENRVVIDYLLPTQSDYIKLFK

Nucleotide

• Length: 336 bp

>T117799 NZ_CP035444:1530942-1531277 [Streptococcus pyogenes]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCTCA
AAACTATTCCTCAACATCAGGTCAGCGTAAAATGGAGCAAATCATTAGCGACATAGAAAAACTCGAGGTTTTCCCAGAAG
TTGGTTTTGATGCCGATGAAAAATATGGTTCAAAAATCATCCATTATCACAGCACTAAAGGTTATACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAGGGGGAAGAAAATAGGGTCGTTATTGATTACTTGCTTCCTACTCAAAGCGACTATAT
AAAGTTATTCAAATAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10934.56 Da
• Isoelectric Point: 5.2318

>AT117799 WP_002988079.1 NZ_CP035444:1530665-1530952 [Streptococcus pyogenes]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Nucleotide

• Length: 288 bp

>AT117799 NZ_CP035444:1530665-1530952 [Streptococcus pyogenes]
ATGACTACAGTAAAAAAAAACAGAGCGGTTACCTTTCAAGCTAATAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCTGAAATCAACAAAAATATTGAGGATGTTCGTCAA
GGGAAGTTTTATACCTCTGAAGAAGTGAGGGCTGAACTTGGACTATAA

Structures

Toxin

• AlphaFold DB: A0A7Z2QKE7

Antitoxin

• AlphaFold DB: A0A4U7GX94