Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 1530665..1531277 Replicon chromosome
Accession NZ_CP035444
Organism Streptococcus pyogenes strain emm90.5

Toxin (Protein)


Gene name parE Uniprot ID Q5X9X8
Locus tag ETT55_RS07700 Protein ID WP_011018227.1
Coordinates 1530942..1531277 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q5X9X9
Locus tag ETT55_RS07695 Protein ID WP_002988079.1
Coordinates 1530665..1530952 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ETT55_RS07670 1525856..1526839 - 984 WP_030126263.1 tagatose-bisphosphate aldolase -
ETT55_RS07675 1526843..1527772 - 930 WP_136021684.1 tagatose-6-phosphate kinase -
ETT55_RS07680 1527818..1528333 - 516 WP_014407849.1 galactose-6-phosphate isomerase subunit LacB -
ETT55_RS07685 1528368..1528796 - 429 WP_011529004.1 galactose-6-phosphate isomerase subunit LacA -
ETT55_RS07690 1529242..1530015 + 774 WP_002993783.1 DeoR/GlpR family DNA-binding transcription regulator -
ETT55_RS07695 1530665..1530952 + 288 WP_002988079.1 DNA-damage-inducible protein J Antitoxin
ETT55_RS07700 1530942..1531277 + 336 WP_011018227.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ETT55_RS07705 1531429..1531899 + 471 WP_136021685.1 site-specific integrase -
ETT55_RS07710 1532043..1532363 + 321 WP_082243205.1 tyrosine-type recombinase/integrase -
ETT55_RS07715 1532531..1532923 - 393 WP_136021686.1 30S ribosomal protein S9 -
ETT55_RS07720 1532944..1533390 - 447 WP_002982710.1 50S ribosomal protein L13 -
ETT55_RS07725 1533608..1533814 - 207 WP_011285176.1 helix-turn-helix transcriptional regulator -
ETT55_RS07730 1533811..1534509 - 699 WP_030126259.1 hypothetical protein -
ETT55_RS07735 1534645..1535505 - 861 WP_030127324.1 DegV family protein -
ETT55_RS07740 1535602..1536120 - 519 WP_002982682.1 NYN domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-105)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 13171.97 Da        Isoelectric Point: 5.2144

>T117799 WP_011018227.1 NZ_CP035444:1530942-1531277 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIISDIEKLEVFPEVGFDADEKYGSKIIHYHSTKGYTLSKD
YIVLYHIEGEENRVVIDYLLPTQSDYIKLFK

Download         Length: 336 bp

>T117799 NZ_CP035444:1530942-1531277 [Streptococcus pyogenes]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCTCA
AAACTATTCCTCAACATCAGGTCAGCGTAAAATGGAGCAAATCATTAGCGACATAGAAAAACTCGAGGTTTTCCCAGAAG
TTGGTTTTGATGCCGATGAAAAATATGGTTCAAAAATCATCCATTATCACAGCACTAAAGGTTATACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAGGGGGAAGAAAATAGGGTCGTTATTGATTACTTGCTTCCTACTCAAAGCGACTATAT
AAAGTTATTCAAATAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10934.56 Da        Isoelectric Point: 5.2318

>AT117799 WP_002988079.1 NZ_CP035444:1530665-1530952 [Streptococcus pyogenes]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Download         Length: 288 bp

>AT117799 NZ_CP035444:1530665-1530952 [Streptococcus pyogenes]
ATGACTACAGTAAAAAAAAACAGAGCGGTTACCTTTCAAGCTAATAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCTGAAATCAACAAAAATATTGAGGATGTTCGTCAA
GGGAAGTTTTATACCTCTGAAGAAGTGAGGGCTGAACTTGGACTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7Z2QKE7

Antitoxin

Source ID Structure
AlphaFold DB A0A4U7GX94

References