Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 1633196..1633808 Replicon chromosome
Accession NZ_CP035443
Organism Streptococcus pyogenes strain emm58

Toxin (Protein)


Gene name parE Uniprot ID A0A4Z2JY48
Locus tag ETT56_RS08440 Protein ID WP_002982731.1
Coordinates 1633473..1633808 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q5X9X9
Locus tag ETT56_RS08435 Protein ID WP_002988079.1
Coordinates 1633196..1633483 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ETT56_RS08410 1628375..1629358 - 984 WP_023610648.1 tagatose-bisphosphate aldolase -
ETT56_RS08415 1629362..1630291 - 930 WP_023610632.1 tagatose-6-phosphate kinase -
ETT56_RS08420 1630339..1630854 - 516 WP_002982748.1 galactose-6-phosphate isomerase subunit LacB -
ETT56_RS08425 1630889..1631317 - 429 WP_002982747.1 galactose-6-phosphate isomerase subunit LacA -
ETT56_RS08430 1631762..1632535 + 774 WP_002982738.1 DeoR/GlpR family DNA-binding transcription regulator -
ETT56_RS08435 1633196..1633483 + 288 WP_002988079.1 DNA-damage-inducible protein J Antitoxin
ETT56_RS08440 1633473..1633808 + 336 WP_002982731.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ETT56_RS08445 1633897..1634940 + 1044 Protein_1562 site-specific integrase -
ETT56_RS08450 1635312..1636523 - 1212 WP_013851451.1 hypothetical protein -
ETT56_RS08455 1636725..1637597 + 873 WP_023610636.1 hypothetical protein -
ETT56_RS08460 1637612..1638082 + 471 WP_023610643.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-105)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 13145.88 Da        Isoelectric Point: 5.2144

>T117798 WP_002982731.1 NZ_CP035443:1633473-1633808 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIISDIEKLEVFPEVGFDADEKYGSKISHYHSTKGYTLSKD
YIVLYHIEGEENRVVIDYLLPTQSDYIKLFK

Download         Length: 336 bp

>T117798 NZ_CP035443:1633473-1633808 [Streptococcus pyogenes]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCTCA
AAACTATTCCTCAACATCAGGTCAGCGTAAAATGGAGCAAATCATTAGCGACATAGAAAAACTCGAGGTTTTCCCAGAAG
TTGGTTTTGATGCCGATGAAAAATATGGTTCAAAAATCAGTCATTATCACAGCACTAAAGGTTATACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAGGGGGAAGAAAATAGGGTCGTTATTGATTACTTGCTTCCTACTCAAAGCGACTATAT
AAAGTTATTCAAATAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10934.56 Da        Isoelectric Point: 5.2318

>AT117798 WP_002988079.1 NZ_CP035443:1633196-1633483 [Streptococcus pyogenes]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Download         Length: 288 bp

>AT117798 NZ_CP035443:1633196-1633483 [Streptococcus pyogenes]
ATGACTACAGTAAAAAAAAACAGAGCTGTTACCTTTCAAGCTAATAAAGAATTGGTAAGTGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCTGAAATCAACAAAAATATTGAGGATGTTCGTCAA
GGGAAGTTTTATACCTCTGAAGAAGTGAGGGCTGAACTTGGACTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4Z2JY48

Antitoxin

Source ID Structure
AlphaFold DB A0A4U7GX94

References