Detailed information of TA system TA117797

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelB(antitoxin)
• Location: 1574177..1574789
• Replicon: chromosome
• Accession: NZ_CP035442
• Organism: Streptococcus pyogenes strain emm25

Toxin (Protein)

• Gene name: parE
• Uniprot ID: Q5X9X8
• Locus tag: ETT57_RS08110
• Protein ID: WP_011018227.1
• Coordinates: 1574454..1574789 (+)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: ETT57_RS08105
• Protein ID: WP_136048633.1
• Coordinates: 1574177..1574464 (+)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ETT57_RS08080	1569354..1570337	-	984	WP_014635708.1	tagatose-bisphosphate aldolase	-
ETT57_RS08085	1570341..1571270	-	930	WP_136048634.1	tagatose-6-phosphate kinase	-
ETT57_RS08090	1571318..1571833	-	516	WP_002982748.1	galactose-6-phosphate isomerase subunit LacB	-
ETT57_RS08095	1571868..1572296	-	429	WP_002982747.1	galactose-6-phosphate isomerase subunit LacA	-
ETT57_RS08100	1572743..1573516	+	774	WP_136047241.1	DeoR/GlpR family DNA-binding transcription regulator	-
ETT57_RS08105	1574177..1574464	+	288	WP_136048633.1	hypothetical protein	Antitoxin
ETT57_RS08110	1574454..1574789	+	336	WP_011018227.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
ETT57_RS08115	1574878..1575912	+	1035	Protein_1487	site-specific integrase	-
ETT57_RS08120	1576270..1577481	-	1212	WP_136048632.1	hypothetical protein	-
ETT57_RS08125	1577622..1578551	-	930	Protein_1489	IS30 family transposase	-
ETT57_RS08130	1578769..1579641	+	873	WP_136048631.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	1577493..1578551	1058

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-105)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 13171.97 Da
• Isoelectric Point: 5.2144

>T117797 WP_011018227.1 NZ_CP035442:1574454-1574789 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIISDIEKLEVFPEVGFDADEKYGSKIIHYHSTKGYTLSKD
YIVLYHIEGEENRVVIDYLLPTQSDYIKLFK

Nucleotide

• Length: 336 bp

>T117797 NZ_CP035442:1574454-1574789 [Streptococcus pyogenes]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCTCA
AAACTATTCCTCAACATCAGGTCAGCGTAAAATGGAGCAAATCATTAGCGACATAGAAAAACTCGAGGTTTTCCCAGAAG
TTGGTTTTGATGCCGATGAAAAATATGGTTCAAAAATCATCCATTATCACAGCACTAAAGGTTATACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAGGGGGAAGAAAATAGGGTCGTTATTGATTACTTGCTTCCTACTCAAAGCGACTATAT
AAAGTTATTCAAATAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10964.65 Da
• Isoelectric Point: 5.2318

>AT117797 WP_136048633.1 NZ_CP035442:1574177-1574464 [Streptococcus pyogenes]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLMEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Nucleotide

• Length: 288 bp

>AT117797 NZ_CP035442:1574177-1574464 [Streptococcus pyogenes]
ATGACTACAGTAAAAAAAAACAGAGCGGTTACCTTTCAAGCTAATAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
TGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAACAATTTCAAGCTGAAATCAACAAAAATATTGAGGATGTTCGTCAA
GGGAAGTTTTATACCTCTGAAGAAGTGAGGGCTGAACTTGGACTATAA

Structures

Toxin

• AlphaFold DB: A0A7Z2QKE7