Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 264534..265146 Replicon chromosome
Accession NZ_CP035441
Organism Streptococcus pyogenes strain emm1

Toxin (Protein)


Gene name parE Uniprot ID J7M9F1
Locus tag ETT58_RS01480 Protein ID WP_010922665.1
Coordinates 264534..264869 (-) Length 112 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q5X9X9
Locus tag ETT58_RS01485 Protein ID WP_002988079.1
Coordinates 264859..265146 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ETT58_RS01445 259912..260430 + 519 WP_002982682.1 NYN domain-containing protein -
ETT58_RS01450 260527..261387 + 861 WP_002982687.1 DegV family protein -
ETT58_RS01455 261523..262029 + 507 WP_002988070.1 hypothetical protein -
ETT58_RS01460 262026..262232 + 207 WP_002982695.1 helix-turn-helix transcriptional regulator -
ETT58_RS01465 262450..262896 + 447 WP_002982710.1 50S ribosomal protein L13 -
ETT58_RS01470 262917..263309 + 393 WP_002982716.1 30S ribosomal protein S9 -
ETT58_RS09465 263429..263866 - 438 WP_076639988.1 site-specific integrase -
ETT58_RS09470 263912..264382 - 471 Protein_231 integrase -
ETT58_RS01480 264534..264869 - 336 WP_010922665.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ETT58_RS01485 264859..265146 - 288 WP_002988079.1 DNA-damage-inducible protein J Antitoxin
ETT58_RS01495 265807..266580 - 774 WP_002982738.1 DeoR/GlpR family DNA-binding transcription regulator -
ETT58_RS01500 267027..267455 + 429 WP_010922664.1 galactose-6-phosphate isomerase subunit LacA -
ETT58_RS01505 267490..268005 + 516 WP_002988082.1 galactose-6-phosphate isomerase subunit LacB -
ETT58_RS01510 268053..268982 + 930 WP_010922663.1 tagatose-6-phosphate kinase -
ETT58_RS01515 268986..269969 + 984 WP_002982755.1 tagatose-bisphosphate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-105)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 13185.99 Da        Isoelectric Point: 5.2144

>T117796 WP_010922665.1 NZ_CP035441:c264869-264534 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIISDIEKLEVFPEVGFDADEKYGSKIIHYHSTKGYTLSKD
YIVLYHIEGEENRIVIDYLLPTQSDYIKLFK

Download         Length: 336 bp

>T117796 NZ_CP035441:c264869-264534 [Streptococcus pyogenes]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCTCA
AAACTATTCCTCAACATCAGGTCAGCGTAAAATGGAGCAAATCATTAGCGACATAGAAAAACTCGAGGTTTTCCCAGAAG
TTGGTTTTGATGCCGATGAAAAATATGGTTCAAAAATCATCCATTATCACAGCACTAAAGGTTATACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAGGGGGAAGAAAATAGGATCGTTATTGATTACTTGCTTCCTACTCAAAGCGACTATAT
AAAGTTATTCAAATAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10934.56 Da        Isoelectric Point: 5.2318

>AT117796 WP_002988079.1 NZ_CP035441:c265146-264859 [Streptococcus pyogenes]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Download         Length: 288 bp

>AT117796 NZ_CP035441:c265146-264859 [Streptococcus pyogenes]
ATGACTACAGTAAAAAAAAACAGAGCGGTTACCTTTCAAGCTAATAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCTGAAATCAACAAAAATATTGAGGATGTTCGTCAA
GGGAAGTTTTATACCTCTGAGGAAGTGAGGGCTGAACTTGGACTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB J7M9F1

Antitoxin

Source ID Structure
AlphaFold DB A0A4U7GX94

References