Detailed information of TA system TA117795

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelB(antitoxin)
• Location: 1542091..1542703
• Replicon: chromosome
• Accession: NZ_CP035440
• Organism: Streptococcus pyogenes strain emm124

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: ETT59_RS07775
• Protein ID: WP_014635711.1
• Coordinates: 1542368..1542703 (+)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: Q5X9X9
• Locus tag: ETT59_RS07770
• Protein ID: WP_002988079.1
• Coordinates: 1542091..1542378 (+)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ETT59_RS07745	1537282..1538265	-	984	WP_032461210.1	tagatose-bisphosphate aldolase	-
ETT59_RS07750	1538269..1539198	-	930	WP_053308612.1	tagatose-6-phosphate kinase	-
ETT59_RS07755	1539244..1539759	-	516	WP_136275278.1	galactose-6-phosphate isomerase subunit LacB	-
ETT59_RS07760	1539794..1540222	-	429	WP_002982747.1	galactose-6-phosphate isomerase subunit LacA	-
ETT59_RS07765	1540668..1541441	+	774	WP_023605292.1	DeoR/GlpR family DNA-binding transcription regulator	-
ETT59_RS07770	1542091..1542378	+	288	WP_002988079.1	DNA-damage-inducible protein J	Antitoxin
ETT59_RS07775	1542368..1542703	+	336	WP_014635711.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
ETT59_RS09055	1542854..1543324	+	471	Protein_1419	integrase	-
ETT59_RS09060	1543287..1543649	+	363	WP_180372423.1	tyrosine-type recombinase/integrase	-
ETT59_RS09065	1543685..1543834	+	150	WP_011285175.1	integrase	-
ETT59_RS07790	1543967..1544359	-	393	WP_002982716.1	30S ribosomal protein S9	-
ETT59_RS07795	1544380..1544826	-	447	WP_002982710.1	50S ribosomal protein L13	-
ETT59_RS07800	1545044..1545250	-	207	WP_136274474.1	helix-turn-helix transcriptional regulator	-
ETT59_RS07805	1545247..1545945	-	699	WP_168393626.1	hypothetical protein	-
ETT59_RS07810	1546081..1546941	-	861	WP_011529009.1	DegV family protein	-
ETT59_RS07815	1547038..1547556	-	519	WP_011285178.1	NYN domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-106)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 13173.94 Da
• Isoelectric Point: 5.6809

>T117795 WP_014635711.1 NZ_CP035440:1542368-1542703 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIISDIEKLEVFPEVGFDADEKYGSKISHYHSTKGYTLSKD
YIVLYHIEGEENRVVIDYLLPTRSDYIKLFK

Nucleotide

• Length: 336 bp

>T117795 NZ_CP035440:1542368-1542703 [Streptococcus pyogenes]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCTCA
AAACTATTCCTCAACATCAGGTCAGCGTAAAATGGAGCAAATCATTAGCGACATAGAAAAACTCGAGGTTTTCCCAGAAG
TTGGTTTTGATGCCGATGAAAAATATGGTTCAAAAATCAGCCATTATCACAGCACTAAAGGTTACACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAGGGGGAAGAAAATAGGGTCGTTATTGATTACTTGCTTCCTACTCGAAGCGACTATAT
AAAGTTATTCAAATAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10934.56 Da
• Isoelectric Point: 5.2318

>AT117795 WP_002988079.1 NZ_CP035440:1542091-1542378 [Streptococcus pyogenes]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Nucleotide

• Length: 288 bp

>AT117795 NZ_CP035440:1542091-1542378 [Streptococcus pyogenes]
ATGACTACAGTAAAAAAAAACAGAGCGGTTACCTTTCAAGCTAATAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCTGAAATCAATAAAAATATTGAGGATGTTCGTCAA
GGGAAGTTTTATACCTCTGAAGAAGTGAGGGCTGAACTTGGACTATAA

Structures

Antitoxin

• AlphaFold DB: A0A4U7GX94