Detailed information of TA system TA117794

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelB(antitoxin)
• Location: 1700111..1700723
• Replicon: chromosome
• Accession: NZ_CP035438
• Organism: Streptococcus pyogenes strain emm22.8

Toxin (Protein)

• Gene name: parE
• Uniprot ID: A0A0H3C0F8
• Locus tag: ETT61_RS08835
• Protein ID: WP_009880846.1
• Coordinates: 1700388..1700723 (+)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: ETT61_RS08830
• Protein ID: WP_136020345.1
• Coordinates: 1700111..1700398 (+)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ETT61_RS08805	1695287..1696270	-	984	WP_136020341.1	tagatose-bisphosphate aldolase	-
ETT61_RS08810	1696274..1697203	-	930	WP_136020342.1	tagatose-6-phosphate kinase	-
ETT61_RS08815	1697251..1697766	-	516	WP_136020343.1	galactose-6-phosphate isomerase subunit LacB	-
ETT61_RS08820	1697801..1698229	-	429	WP_002982747.1	galactose-6-phosphate isomerase subunit LacA	-
ETT61_RS08825	1698674..1699447	+	774	WP_136020344.1	DeoR/GlpR family DNA-binding transcription regulator	-
ETT61_RS08830	1700111..1700398	+	288	WP_136020345.1	hypothetical protein	Antitoxin
ETT61_RS08835	1700388..1700723	+	336	WP_009880846.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
ETT61_RS08840	1700812..1701855	+	1044	Protein_1630	site-specific integrase	-
ETT61_RS08850	1701987..1702379	-	393	WP_002982716.1	30S ribosomal protein S9	-
ETT61_RS08855	1702400..1702846	-	447	WP_002982710.1	50S ribosomal protein L13	-
ETT61_RS08860	1703064..1703270	-	207	WP_002982695.1	helix-turn-helix transcriptional regulator	-
ETT61_RS08865	1703267..1703965	-	699	WP_168389642.1	hypothetical protein	-
ETT61_RS08870	1704101..1704961	-	861	WP_136020347.1	DegV family protein	-
ETT61_RS08875	1705058..1705576	-	519	WP_002982682.1	NYN domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (7-107)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 13204.95 Da
• Isoelectric Point: 5.6809

>T117794 WP_009880846.1 NZ_CP035438:1700388-1700723 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIISDIEKLEVFREVGFDADEKYGSKISHYHSTKGYTLSKD
YIVLYHIEGEENRVVIDYLLPTQSDYIKLFK

Nucleotide

• Length: 336 bp

>T117794 NZ_CP035438:1700388-1700723 [Streptococcus pyogenes]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCTCA
AAACTATTCCTCAACATCAGGTCAGCGTAAAATGGAGCAAATCATTAGCGACATAGAAAAACTCGAGGTTTTCCGAGAAG
TTGGTTTTGATGCTGATGAAAAATATGGTTCAAAAATCAGCCATTATCACAGCACTAAAGGTTATACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAGGGGGAAGAAAATAGGGTCGTTATTGATTACTTGCTTCCTACTCAAAGCGACTATAT
AAAGTTATTCAAATAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 11006.62 Da
• Isoelectric Point: 4.9341

>AT117794 WP_136020345.1 NZ_CP035438:1700111-1700398 [Streptococcus pyogenes]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
EKFYTSEEVRAELGL

Nucleotide

• Length: 288 bp

>AT117794 NZ_CP035438:1700111-1700398 [Streptococcus pyogenes]
ATGACTACAGTAAAAAAAAACAGAGCGGTTACCTTTCAAGCTAATAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCTGAAATCAACAAAAATATTGAGGATGTTCGTCAA
GAGAAGTTTTATACCTCTGAAGAAGTGAGGGCTGAACTTGGACTATAA

Structures

Toxin

• AlphaFold DB: A0A0H3C0F8