Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 1559932..1560544 Replicon chromosome
Accession NZ_CP035437
Organism Streptococcus pyogenes strain emm78.3

Toxin (Protein)


Gene name parE Uniprot ID Q5X9X8
Locus tag ETT62_RS07905 Protein ID WP_011018227.1
Coordinates 1560209..1560544 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q5X9X9
Locus tag ETT62_RS07900 Protein ID WP_002988079.1
Coordinates 1559932..1560219 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ETT62_RS07875 1555166..1556149 - 984 WP_014407847.1 tagatose-bisphosphate aldolase -
ETT62_RS07880 1556153..1557082 - 930 WP_136120866.1 tagatose-6-phosphate kinase -
ETT62_RS07885 1557128..1557643 - 516 WP_023611281.1 galactose-6-phosphate isomerase subunit LacB -
ETT62_RS07890 1557678..1558106 - 429 WP_002982747.1 galactose-6-phosphate isomerase subunit LacA -
ETT62_RS07895 1558509..1559282 + 774 WP_136098626.1 DeoR/GlpR family DNA-binding transcription regulator -
ETT62_RS07900 1559932..1560219 + 288 WP_002988079.1 DNA-damage-inducible protein J Antitoxin
ETT62_RS07905 1560209..1560544 + 336 WP_011018227.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ETT62_RS07910 1560633..1561677 + 1045 Protein_1450 site-specific integrase -
ETT62_RS07915 1561797..1562189 - 393 WP_002982716.1 30S ribosomal protein S9 -
ETT62_RS07920 1562210..1562656 - 447 WP_002982710.1 50S ribosomal protein L13 -
ETT62_RS07925 1562874..1563080 - 207 WP_002982695.1 helix-turn-helix transcriptional regulator -
ETT62_RS07930 1563077..1563583 - 507 WP_168435473.1 hypothetical protein -
ETT62_RS07935 1563719..1564579 - 861 WP_011529009.1 DegV family protein -
ETT62_RS07940 1564676..1565194 - 519 WP_002982682.1 NYN domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-105)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 13171.97 Da        Isoelectric Point: 5.2144

>T117791 WP_011018227.1 NZ_CP035437:1560209-1560544 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIISDIEKLEVFPEVGFDADEKYGSKIIHYHSTKGYTLSKD
YIVLYHIEGEENRVVIDYLLPTQSDYIKLFK

Download         Length: 336 bp

>T117791 NZ_CP035437:1560209-1560544 [Streptococcus pyogenes]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCTCA
AAACTATTCCTCAACATCAGGTCAGCGTAAAATGGAGCAAATCATTAGCGACATAGAAAAACTCGAGGTTTTCCCAGAAG
TTGGTTTTGATGCCGATGAAAAATATGGTTCAAAAATCATCCATTATCACAGCACTAAAGGTTATACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAGGGGGAAGAAAATAGGGTCGTTATTGATTACTTGCTTCCTACTCAAAGCGACTATAT
AAAGTTATTCAAATAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10934.56 Da        Isoelectric Point: 5.2318

>AT117791 WP_002988079.1 NZ_CP035437:1559932-1560219 [Streptococcus pyogenes]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Download         Length: 288 bp

>AT117791 NZ_CP035437:1559932-1560219 [Streptococcus pyogenes]
ATGACTACAGTAAAAAAAAACAGAGCGGTTACCTTTCAAGCTAATAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAACAATTTCAAGCTGAAATCAACAAAAATATTGAGGATGTTCGTCAA
GGGAAGTTTTATACCTCTGAAGAAGTGAGGGCTGAACTTGGACTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7Z2QKE7

Antitoxin

Source ID Structure
AlphaFold DB A0A4U7GX94

References