Detailed information of TA system TA117791

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelB(antitoxin)
• Location: 1559932..1560544
• Replicon: chromosome
• Accession: NZ_CP035437
• Organism: Streptococcus pyogenes strain emm78.3

Toxin (Protein)

• Gene name: parE
• Uniprot ID: Q5X9X8
• Locus tag: ETT62_RS07905
• Protein ID: WP_011018227.1
• Coordinates: 1560209..1560544 (+)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: Q5X9X9
• Locus tag: ETT62_RS07900
• Protein ID: WP_002988079.1
• Coordinates: 1559932..1560219 (+)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ETT62_RS07875	1555166..1556149	-	984	WP_014407847.1	tagatose-bisphosphate aldolase	-
ETT62_RS07880	1556153..1557082	-	930	WP_136120866.1	tagatose-6-phosphate kinase	-
ETT62_RS07885	1557128..1557643	-	516	WP_023611281.1	galactose-6-phosphate isomerase subunit LacB	-
ETT62_RS07890	1557678..1558106	-	429	WP_002982747.1	galactose-6-phosphate isomerase subunit LacA	-
ETT62_RS07895	1558509..1559282	+	774	WP_136098626.1	DeoR/GlpR family DNA-binding transcription regulator	-
ETT62_RS07900	1559932..1560219	+	288	WP_002988079.1	DNA-damage-inducible protein J	Antitoxin
ETT62_RS07905	1560209..1560544	+	336	WP_011018227.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
ETT62_RS07910	1560633..1561677	+	1045	Protein_1450	site-specific integrase	-
ETT62_RS07915	1561797..1562189	-	393	WP_002982716.1	30S ribosomal protein S9	-
ETT62_RS07920	1562210..1562656	-	447	WP_002982710.1	50S ribosomal protein L13	-
ETT62_RS07925	1562874..1563080	-	207	WP_002982695.1	helix-turn-helix transcriptional regulator	-
ETT62_RS07930	1563077..1563583	-	507	WP_168435473.1	hypothetical protein	-
ETT62_RS07935	1563719..1564579	-	861	WP_011529009.1	DegV family protein	-
ETT62_RS07940	1564676..1565194	-	519	WP_002982682.1	NYN domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-105)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 13171.97 Da
• Isoelectric Point: 5.2144

>T117791 WP_011018227.1 NZ_CP035437:1560209-1560544 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIISDIEKLEVFPEVGFDADEKYGSKIIHYHSTKGYTLSKD
YIVLYHIEGEENRVVIDYLLPTQSDYIKLFK

Nucleotide

• Length: 336 bp

>T117791 NZ_CP035437:1560209-1560544 [Streptococcus pyogenes]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCTCA
AAACTATTCCTCAACATCAGGTCAGCGTAAAATGGAGCAAATCATTAGCGACATAGAAAAACTCGAGGTTTTCCCAGAAG
TTGGTTTTGATGCCGATGAAAAATATGGTTCAAAAATCATCCATTATCACAGCACTAAAGGTTATACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAGGGGGAAGAAAATAGGGTCGTTATTGATTACTTGCTTCCTACTCAAAGCGACTATAT
AAAGTTATTCAAATAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10934.56 Da
• Isoelectric Point: 5.2318

>AT117791 WP_002988079.1 NZ_CP035437:1559932-1560219 [Streptococcus pyogenes]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Nucleotide

• Length: 288 bp

>AT117791 NZ_CP035437:1559932-1560219 [Streptococcus pyogenes]
ATGACTACAGTAAAAAAAAACAGAGCGGTTACCTTTCAAGCTAATAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAACAATTTCAAGCTGAAATCAACAAAAATATTGAGGATGTTCGTCAA
GGGAAGTTTTATACCTCTGAAGAAGTGAGGGCTGAACTTGGACTATAA

Structures

Toxin

• AlphaFold DB: A0A7Z2QKE7

Antitoxin

• AlphaFold DB: A0A4U7GX94