Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 1551322..1551934 Replicon chromosome
Accession NZ_CP035436
Organism Streptococcus pyogenes strain emm89.14

Toxin (Protein)


Gene name parE Uniprot ID Q5X9X8
Locus tag ETT63_RS07935 Protein ID WP_011018227.1
Coordinates 1551599..1551934 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q5X9X9
Locus tag ETT63_RS07930 Protein ID WP_002988079.1
Coordinates 1551322..1551609 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ETT63_RS07905 1546502..1547485 - 984 WP_136267651.1 tagatose-bisphosphate aldolase -
ETT63_RS07910 1547489..1548418 - 930 WP_136267649.1 tagatose-6-phosphate kinase -
ETT63_RS07915 1548464..1548979 - 516 WP_002988082.1 galactose-6-phosphate isomerase subunit LacB -
ETT63_RS07920 1549014..1549442 - 429 WP_002982747.1 galactose-6-phosphate isomerase subunit LacA -
ETT63_RS07925 1549888..1550661 + 774 WP_011285171.1 DeoR/GlpR family DNA-binding transcription regulator -
ETT63_RS07930 1551322..1551609 + 288 WP_002988079.1 DNA-damage-inducible protein J Antitoxin
ETT63_RS07935 1551599..1551934 + 336 WP_011018227.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ETT63_RS09245 1552086..1552556 + 471 WP_186798462.1 integrase -
ETT63_RS09250 1552519..1553067 + 549 WP_115224415.1 site-specific integrase -
ETT63_RS07950 1553199..1553591 - 393 WP_002982716.1 30S ribosomal protein S9 -
ETT63_RS07955 1553612..1554058 - 447 WP_002982710.1 50S ribosomal protein L13 -
ETT63_RS07960 1554276..1554482 - 207 WP_011529007.1 helix-turn-helix transcriptional regulator -
ETT63_RS07965 1554479..1555177 - 699 WP_168688209.1 hypothetical protein -
ETT63_RS07970 1555313..1556173 - 861 WP_032465242.1 DegV family protein -
ETT63_RS07975 1556270..1556788 - 519 WP_002982682.1 NYN domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-105)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 13171.97 Da        Isoelectric Point: 5.2144

>T117790 WP_011018227.1 NZ_CP035436:1551599-1551934 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIISDIEKLEVFPEVGFDADEKYGSKIIHYHSTKGYTLSKD
YIVLYHIEGEENRVVIDYLLPTQSDYIKLFK

Download         Length: 336 bp

>T117790 NZ_CP035436:1551599-1551934 [Streptococcus pyogenes]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCTCA
AAACTATTCCTCAACATCAGGTCAGCGTAAAATGGAGCAAATCATTAGCGACATAGAAAAACTCGAGGTTTTCCCAGAAG
TTGGTTTTGATGCCGATGAAAAATATGGTTCAAAAATCATCCATTATCACAGCACTAAAGGTTATACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAGGGGGAAGAAAATAGGGTCGTTATTGATTACTTGCTTCCTACTCAAAGCGACTATAT
AAAGTTATTCAAATAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10934.56 Da        Isoelectric Point: 5.2318

>AT117790 WP_002988079.1 NZ_CP035436:1551322-1551609 [Streptococcus pyogenes]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Download         Length: 288 bp

>AT117790 NZ_CP035436:1551322-1551609 [Streptococcus pyogenes]
ATGACTACAGTAAAAAAAAACAGAGCGGTTACCTTTCAAGCTAATAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAACAATTTCAAGCTGAAATCAACAAAAATATTGAGGATGTTCGTCAA
GGGAAGTTTTATACCTCTGAAGAAGTGAGGGCTGAACTTGGACTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7Z2QKE7

Antitoxin

Source ID Structure
AlphaFold DB A0A4U7GX94

References