Detailed information of TA system TA117789

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelB(antitoxin)
• Location: 1532667..1533279
• Replicon: chromosome
• Accession: NZ_CP035435
• Organism: Streptococcus pyogenes strain emm64.3

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: ETT64_RS07955
• Protein ID: WP_038432559.1
• Coordinates: 1532944..1533279 (+)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: Q5X9X9
• Locus tag: ETT64_RS07950
• Protein ID: WP_002988079.1
• Coordinates: 1532667..1532954 (+)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ETT64_RS07925	1527848..1528831	-	984	WP_014407847.1	tagatose-bisphosphate aldolase	-
ETT64_RS07930	1528835..1529764	-	930	WP_023609980.1	tagatose-6-phosphate kinase	-
ETT64_RS07935	1529810..1530325	-	516	WP_014407849.1	galactose-6-phosphate isomerase subunit LacB	-
ETT64_RS07940	1530360..1530788	-	429	WP_011529004.1	galactose-6-phosphate isomerase subunit LacA	-
ETT64_RS07945	1531233..1532006	+	774	WP_011285171.1	DeoR/GlpR family DNA-binding transcription regulator	-
ETT64_RS07950	1532667..1532954	+	288	WP_002988079.1	DNA-damage-inducible protein J	Antitoxin
ETT64_RS07955	1532944..1533279	+	336	WP_038432559.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
ETT64_RS09220	1533431..1533901	+	471	Protein_1459	integrase	-
ETT64_RS09225	1534263..1534412	+	150	WP_011285175.1	integrase	-
ETT64_RS07975	1534544..1534936	-	393	WP_002982716.1	30S ribosomal protein S9	-
ETT64_RS07980	1534957..1535403	-	447	WP_002982710.1	50S ribosomal protein L13	-
ETT64_RS07985	1535621..1535827	-	207	WP_002982695.1	helix-turn-helix transcriptional regulator	-
ETT64_RS07990	1535824..1536522	-	699	WP_186788945.1	hypothetical protein	-
ETT64_RS07995	1536658..1537518	-	861	WP_030127324.1	DegV family protein	-
ETT64_RS08000	1537615..1538133	-	519	WP_011285178.1	NYN domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (7-107)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 13159.91 Da
• Isoelectric Point: 5.2144

>T117789 WP_038432559.1 NZ_CP035435:1532944-1533279 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIISDIEKLEVFPEVGFDADEKYGSKISHYHSTKGYTLSKD
YIILYHIEGEENRVVIDYLLPTQSDYIKLFK

Nucleotide

• Length: 336 bp

>T117789 NZ_CP035435:1532944-1533279 [Streptococcus pyogenes]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCTCA
AAACTACTCCTCAACATCAGGTCAGCGTAAAATGGAGCAAATCATTAGCGACATAGAAAAACTCGAGGTTTTCCCAGAAG
TTGGTTTTGATGCCGATGAAAAATATGGTTCAAAAATCAGTCATTATCACAGCACTAAAGGTTATACCTTAAGTAAAGAT
TATATTATCCTATACCATATCGAGGGGGAAGAAAATAGGGTCGTTATTGATTACTTGCTTCCTACTCAAAGCGACTATAT
AAAGTTATTCAAATAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10934.56 Da
• Isoelectric Point: 5.2318

>AT117789 WP_002988079.1 NZ_CP035435:1532667-1532954 [Streptococcus pyogenes]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Nucleotide

• Length: 288 bp

>AT117789 NZ_CP035435:1532667-1532954 [Streptococcus pyogenes]
ATGACTACAGTAAAAAAAAACAGAGCGGTTACCTTTCAAGCTAACAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCTGAAATCAACAAAAATATTGAGGATGTTCGTCAA
GGGAAGTTTTATACCTCTGAAGAAGTGAGGGCTGAACTTGGACTATAA

Structures

Antitoxin

• AlphaFold DB: A0A4U7GX94