Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 1626591..1627203 Replicon chromosome
Accession NZ_CP035434
Organism Streptococcus pyogenes strain emm75.1

Toxin (Protein)


Gene name parE Uniprot ID A0A4Z2JY48
Locus tag ETT65_RS08295 Protein ID WP_002982731.1
Coordinates 1626868..1627203 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q5X9X9
Locus tag ETT65_RS08290 Protein ID WP_002988079.1
Coordinates 1626591..1626878 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ETT65_RS08260 1621769..1622752 - 984 WP_014407847.1 tagatose-bisphosphate aldolase -
ETT65_RS08265 1622756..1623685 - 930 WP_023609980.1 tagatose-6-phosphate kinase -
ETT65_RS08270 1623733..1624248 - 516 WP_023612880.1 galactose-6-phosphate isomerase subunit LacB -
ETT65_RS08275 1624283..1624711 - 429 WP_011529004.1 galactose-6-phosphate isomerase subunit LacA -
ETT65_RS08280 1625157..1625930 + 774 WP_002982738.1 DeoR/GlpR family DNA-binding transcription regulator -
ETT65_RS08290 1626591..1626878 + 288 WP_002988079.1 DNA-damage-inducible protein J Antitoxin
ETT65_RS08295 1626868..1627203 + 336 WP_002982731.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ETT65_RS08300 1627355..1627537 + 183 WP_011285716.1 integrase -
ETT65_RS08305 1627940..1628307 + 368 Protein_1533 tyrosine-type recombinase/integrase -
ETT65_RS08310 1628593..1628937 - 345 Protein_1534 type II toxin-antitoxin system RelE/ParE family toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - ska 1625135..1694279 69144


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-105)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 13145.88 Da        Isoelectric Point: 5.2144

>T117788 WP_002982731.1 NZ_CP035434:1626868-1627203 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIISDIEKLEVFPEVGFDADEKYGSKISHYHSTKGYTLSKD
YIVLYHIEGEENRVVIDYLLPTQSDYIKLFK

Download         Length: 336 bp

>T117788 NZ_CP035434:1626868-1627203 [Streptococcus pyogenes]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCTCA
AAACTACTCCTCAACATCAGGTCAGCGTAAAATGGAGCAAATCATTAGCGACATAGAAAAACTCGAGGTTTTCCCAGAAG
TTGGTTTTGATGCCGATGAAAAATATGGTTCAAAAATCAGTCATTATCACAGCACTAAAGGTTATACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAGGGGGAAGAAAATAGGGTCGTTATTGATTACTTGCTTCCTACTCAAAGCGACTATAT
AAAGTTATTCAAATAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10934.56 Da        Isoelectric Point: 5.2318

>AT117788 WP_002988079.1 NZ_CP035434:1626591-1626878 [Streptococcus pyogenes]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Download         Length: 288 bp

>AT117788 NZ_CP035434:1626591-1626878 [Streptococcus pyogenes]
ATGACTACAGTAAAAAAAAACAGAGCGGTTACCTTTCAAGCTAATAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCTGAAATCAACAAAAATATTGAGGATGTTCGTCAA
GGGAAGTTTTATACCTCTGAAGAAGTGAGGGCTGAACTTGGACTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4Z2JY48

Antitoxin

Source ID Structure
AlphaFold DB A0A4U7GX94

References