Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) sezT-pezT/zeta-HTH_XRE
Location 957764..959016 Replicon chromosome
Accession NZ_CP035434
Organism Streptococcus pyogenes strain emm75.1

Toxin (Protein)


Gene name sezT Uniprot ID -
Locus tag ETT65_RS04985 Protein ID WP_136075791.1
Coordinates 957764..958540 (-) Length 259 a.a.

Antitoxin (Protein)


Gene name pezT Uniprot ID -
Locus tag ETT65_RS04990 Protein ID WP_136075790.1
Coordinates 958540..959016 (-) Length 159 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ETT65_RS04965 953051..953413 - 363 WP_136075794.1 hypothetical protein -
ETT65_RS04975 953861..955681 - 1821 WP_136075793.1 ATP-dependent helicase -
ETT65_RS04980 955668..957767 - 2100 WP_136075792.1 AAA family ATPase -
ETT65_RS04985 957764..958540 - 777 WP_136075791.1 zeta toxin family protein Toxin
ETT65_RS04990 958540..959016 - 477 WP_136075790.1 helix-turn-helix domain-containing protein Antitoxin
ETT65_RS04995 959158..959871 + 714 WP_136075788.1 methyltransferase domain-containing protein -
ETT65_RS05000 959868..960851 - 984 WP_136075787.1 hypothetical protein -
ETT65_RS05005 960949..961827 + 879 WP_136075786.1 tyrosine-type recombinase/integrase -
ETT65_RS05010 961831..962133 - 303 WP_136075785.1 hypothetical protein -
ETT65_RS05015 962181..962603 - 423 WP_136075784.1 hypothetical protein -
ETT65_RS05020 962596..962847 - 252 WP_136075783.1 hypothetical protein -
ETT65_RS05025 962905..964005 - 1101 WP_136075782.1 toprim domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 866675..963944 97269


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(24-214)

Antitoxin

Cro/C1-type helix-turn-helix domain

(6-58)


Sequences

Toxin        


Download         Length: 259 a.a.        Molecular weight: 29263.57 Da        Isoelectric Point: 9.3210

>T117787 WP_136075791.1 NZ_CP035434:c958540-957764 [Streptococcus pyogenes]
MTLEAFNQSDFELALKRTIRSLTRGKTSSQKPQAILLGGQSGAGKTTIHRIKQKAFQGNIIIIDGDSYRSLHPNYLALQE
TYGKDSVDYTKGFAGQMVERLVEKLSQKGYHLLIEGTLRTTEIPRQTVLLLRSRNYKVSLAVMATKPELSYLSTLIRYEE
LYALDPNKARATPKEHHDGIVEHLAGNLRELEQGKIFDQIQIYQRDRTCVYDSEIDEGSAAEVLQECLFGKWSKVEEEMM
KVGKERLKQLILGNGVKK

Download         Length: 777 bp

>T117787 NZ_CP035434:c958540-957764 [Streptococcus pyogenes]
ATGACCTTAGAGGCATTTAATCAATCAGACTTTGAATTGGCTCTAAAACGGACCATACGTTCCCTGACAAGGGGAAAAAC
AAGTTCGCAAAAGCCCCAGGCGATTTTGCTAGGTGGGCAGAGCGGAGCAGGGAAGACGACCATTCATCGAATTAAGCAAA
AGGCATTTCAAGGTAATATTATCATTATTGATGGGGACAGTTACCGTTCCCTGCATCCTAATTATCTCGCTTTACAGGAA
ACCTATGGCAAGGATAGTGTGGATTATACCAAAGGGTTTGCGGGGCAAATGGTCGAACGTTTAGTTGAGAAGTTGAGCCA
GAAAGGCTACCACCTGCTCATTGAAGGAACCTTGAGAACGACAGAGATTCCTCGGCAAACAGTTCTGCTATTACGCTCAA
GAAATTACAAAGTGTCCTTGGCCGTGATGGCGACCAAGCCAGAGTTGTCCTATCTTAGCACGCTTATTCGCTATGAGGAG
CTTTATGCCCTAGACCCAAATAAGGCCAGAGCAACCCCTAAAGAGCATCATGATGGCATCGTGGAGCATTTGGCGGGGAA
TCTTCGAGAGTTAGAGCAGGGCAAAATTTTTGACCAGATTCAGATATACCAGAGGGATAGAACCTGTGTCTATGATTCTG
AAATAGATGAAGGTTCAGCAGCAGAAGTGCTACAAGAATGTCTCTTCGGAAAATGGAGTAAGGTGGAGGAGGAGATGATG
AAGGTGGGAAAAGAGCGGTTAAAACAGTTGATTTTAGGAAATGGGGTCAAGAAATGA

Antitoxin


Download         Length: 159 a.a.        Molecular weight: 18107.47 Da        Isoelectric Point: 4.3193

>AT117787 WP_136075790.1 NZ_CP035434:c959016-958540 [Streptococcus pyogenes]
MIQANIKALRQEQQLSQSEFAEKIGISRNSLSRYENGTSSVSTELIDRICCQFNVSYVDIVGEEKMLTPVEDYQLTLKIE
VMKERGAAVLSRLYRHQDGLGIAFDDDTNPWVLMSDDLSDLINTKIYLVDSFDEVERYNGYLDGIERMLEMTKHQVVA

Download         Length: 477 bp

>AT117787 NZ_CP035434:c959016-958540 [Streptococcus pyogenes]
ATGATTCAAGCAAATATTAAGGCTCTTCGCCAAGAGCAACAATTGTCTCAATCAGAATTTGCGGAGAAGATTGGGATTTC
TCGTAATAGCCTGAGTCGTTACGAGAATGGCACAAGCTCTGTATCGACTGAACTGATTGATCGCATTTGTTGTCAGTTCA
ATGTTTCTTATGTGGATATTGTGGGGGAAGAAAAAATGTTGACACCAGTAGAAGATTACCAGTTGACCTTAAAAATTGAG
GTCATGAAAGAGCGAGGCGCGGCCGTTTTATCCAGATTATATCGTCACCAGGATGGATTGGGCATTGCCTTTGATGATGA
CACCAATCCTTGGGTGTTGATGAGCGATGACCTATCAGACCTCATCAATACCAAGATTTATCTGGTGGACAGCTTTGATG
AAGTTGAGCGTTACAATGGCTACTTGGATGGTATTGAGCGGATGCTAGAAATGACTAAGCATCAGGTGGTGGCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References