Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 1562413..1563025 Replicon chromosome
Accession NZ_CP035433
Organism Streptococcus pyogenes strain emm65

Toxin (Protein)


Gene name parE Uniprot ID Q5X9X8
Locus tag ETT66_RS07905 Protein ID WP_011018227.1
Coordinates 1562690..1563025 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q5X9X9
Locus tag ETT66_RS07900 Protein ID WP_002988079.1
Coordinates 1562413..1562700 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ETT66_RS07875 1557605..1558588 - 984 WP_014407847.1 tagatose-bisphosphate aldolase -
ETT66_RS07880 1558592..1559521 - 930 WP_136286461.1 tagatose-6-phosphate kinase -
ETT66_RS07885 1559567..1560082 - 516 WP_014407849.1 galactose-6-phosphate isomerase subunit LacB -
ETT66_RS07890 1560117..1560545 - 429 WP_011529004.1 galactose-6-phosphate isomerase subunit LacA -
ETT66_RS07895 1560990..1561763 + 774 WP_002982738.1 DeoR/GlpR family DNA-binding transcription regulator -
ETT66_RS07900 1562413..1562700 + 288 WP_002988079.1 DNA-damage-inducible protein J Antitoxin
ETT66_RS07905 1562690..1563025 + 336 WP_011018227.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ETT66_RS09025 1563177..1563647 + 471 Protein_1452 integrase -
ETT66_RS09030 1563980..1564129 + 150 WP_011285175.1 integrase -
ETT66_RS07920 1564249..1564641 - 393 WP_002982716.1 30S ribosomal protein S9 -
ETT66_RS07925 1564662..1565108 - 447 WP_002982710.1 50S ribosomal protein L13 -
ETT66_RS07930 1565326..1565532 - 207 WP_109828617.1 helix-turn-helix transcriptional regulator -
ETT66_RS07935 1565529..1566219 - 691 Protein_1457 hypothetical protein -
ETT66_RS07940 1566364..1567224 - 861 WP_136286459.1 DegV family protein -
ETT66_RS07945 1567321..1567839 - 519 WP_011285178.1 NYN domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-105)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 13171.97 Da        Isoelectric Point: 5.2144

>T117786 WP_011018227.1 NZ_CP035433:1562690-1563025 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIISDIEKLEVFPEVGFDADEKYGSKIIHYHSTKGYTLSKD
YIVLYHIEGEENRVVIDYLLPTQSDYIKLFK

Download         Length: 336 bp

>T117786 NZ_CP035433:1562690-1563025 [Streptococcus pyogenes]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCTCA
AAACTATTCCTCAACATCAGGTCAGCGTAAAATGGAGCAAATCATTAGCGACATAGAAAAACTCGAGGTTTTCCCAGAAG
TTGGTTTTGATGCCGATGAAAAATATGGTTCAAAAATCATCCATTATCACAGCACTAAAGGTTATACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAGGGGGAAGAAAATAGGGTCGTTATTGATTACTTGCTTCCTACTCAAAGCGACTATAT
AAAGTTATTCAAATAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10934.56 Da        Isoelectric Point: 5.2318

>AT117786 WP_002988079.1 NZ_CP035433:1562413-1562700 [Streptococcus pyogenes]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Download         Length: 288 bp

>AT117786 NZ_CP035433:1562413-1562700 [Streptococcus pyogenes]
ATGACTACAGTAAAAAAAAACAGAGCGGTTACCTTTCAAGCTAATAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCTGAAATCAACAAAAATATTGAGGATGTTCGTCAA
GGGAAGTTTTATACCTCTGAAGAAGTGAGGGCTGAACTTGGACTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7Z2QKE7

Antitoxin

Source ID Structure
AlphaFold DB A0A4U7GX94

References