Detailed information of TA system TA117786

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelB(antitoxin)
• Location: 1562413..1563025
• Replicon: chromosome
• Accession: NZ_CP035433
• Organism: Streptococcus pyogenes strain emm65

Toxin (Protein)

• Gene name: parE
• Uniprot ID: Q5X9X8
• Locus tag: ETT66_RS07905
• Protein ID: WP_011018227.1
• Coordinates: 1562690..1563025 (+)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: Q5X9X9
• Locus tag: ETT66_RS07900
• Protein ID: WP_002988079.1
• Coordinates: 1562413..1562700 (+)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ETT66_RS07875	1557605..1558588	-	984	WP_014407847.1	tagatose-bisphosphate aldolase	-
ETT66_RS07880	1558592..1559521	-	930	WP_136286461.1	tagatose-6-phosphate kinase	-
ETT66_RS07885	1559567..1560082	-	516	WP_014407849.1	galactose-6-phosphate isomerase subunit LacB	-
ETT66_RS07890	1560117..1560545	-	429	WP_011529004.1	galactose-6-phosphate isomerase subunit LacA	-
ETT66_RS07895	1560990..1561763	+	774	WP_002982738.1	DeoR/GlpR family DNA-binding transcription regulator	-
ETT66_RS07900	1562413..1562700	+	288	WP_002988079.1	DNA-damage-inducible protein J	Antitoxin
ETT66_RS07905	1562690..1563025	+	336	WP_011018227.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
ETT66_RS09025	1563177..1563647	+	471	Protein_1452	integrase	-
ETT66_RS09030	1563980..1564129	+	150	WP_011285175.1	integrase	-
ETT66_RS07920	1564249..1564641	-	393	WP_002982716.1	30S ribosomal protein S9	-
ETT66_RS07925	1564662..1565108	-	447	WP_002982710.1	50S ribosomal protein L13	-
ETT66_RS07930	1565326..1565532	-	207	WP_109828617.1	helix-turn-helix transcriptional regulator	-
ETT66_RS07935	1565529..1566219	-	691	Protein_1457	hypothetical protein	-
ETT66_RS07940	1566364..1567224	-	861	WP_136286459.1	DegV family protein	-
ETT66_RS07945	1567321..1567839	-	519	WP_011285178.1	NYN domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-105)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 13171.97 Da
• Isoelectric Point: 5.2144

>T117786 WP_011018227.1 NZ_CP035433:1562690-1563025 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIISDIEKLEVFPEVGFDADEKYGSKIIHYHSTKGYTLSKD
YIVLYHIEGEENRVVIDYLLPTQSDYIKLFK

Nucleotide

• Length: 336 bp

>T117786 NZ_CP035433:1562690-1563025 [Streptococcus pyogenes]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCTCA
AAACTATTCCTCAACATCAGGTCAGCGTAAAATGGAGCAAATCATTAGCGACATAGAAAAACTCGAGGTTTTCCCAGAAG
TTGGTTTTGATGCCGATGAAAAATATGGTTCAAAAATCATCCATTATCACAGCACTAAAGGTTATACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAGGGGGAAGAAAATAGGGTCGTTATTGATTACTTGCTTCCTACTCAAAGCGACTATAT
AAAGTTATTCAAATAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10934.56 Da
• Isoelectric Point: 5.2318

>AT117786 WP_002988079.1 NZ_CP035433:1562413-1562700 [Streptococcus pyogenes]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Nucleotide

• Length: 288 bp

>AT117786 NZ_CP035433:1562413-1562700 [Streptococcus pyogenes]
ATGACTACAGTAAAAAAAAACAGAGCGGTTACCTTTCAAGCTAATAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCTGAAATCAACAAAAATATTGAGGATGTTCGTCAA
GGGAAGTTTTATACCTCTGAAGAAGTGAGGGCTGAACTTGGACTATAA

Structures

Toxin

• AlphaFold DB: A0A7Z2QKE7

Antitoxin

• AlphaFold DB: A0A4U7GX94