Detailed information of TA system TA117785

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelB(antitoxin)
• Location: 1574690..1575302
• Replicon: chromosome
• Accession: NZ_CP035432
• Organism: Streptococcus pyogenes strain emm11

Toxin (Protein)

• Gene name: parE
• Uniprot ID: Q5X9X8
• Locus tag: ETT67_RS08045
• Protein ID: WP_011018227.1
• Coordinates: 1574967..1575302 (+)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: Q5X9X9
• Locus tag: ETT67_RS08040
• Protein ID: WP_002988079.1
• Coordinates: 1574690..1574977 (+)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ETT67_RS08010	1569869..1570852	-	984	WP_011285168.1	tagatose-bisphosphate aldolase	-
ETT67_RS08015	1570856..1571785	-	930	WP_115224651.1	tagatose-6-phosphate kinase	-
ETT67_RS08020	1571833..1572348	-	516	WP_002991700.1	galactose-6-phosphate isomerase subunit LacB	-
ETT67_RS08025	1572383..1572811	-	429	WP_023078895.1	galactose-6-phosphate isomerase subunit LacA	-
ETT67_RS08030	1573256..1574029	+	774	WP_011285171.1	DeoR/GlpR family DNA-binding transcription regulator	-
ETT67_RS08040	1574690..1574977	+	288	WP_002988079.1	DNA-damage-inducible protein J	Antitoxin
ETT67_RS08045	1574967..1575302	+	336	WP_011018227.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
ETT67_RS08050	1575454..1575636	+	183	WP_011285716.1	integrase	-
ETT67_RS08055	1576039..1576406	+	368	Protein_1487	tyrosine-type recombinase/integrase	-
ETT67_RS08060	1576526..1576918	-	393	WP_002982716.1	30S ribosomal protein S9	-
ETT67_RS08065	1576939..1577385	-	447	WP_002982710.1	50S ribosomal protein L13	-
ETT67_RS08070	1577603..1577809	-	207	WP_023078893.1	helix-turn-helix transcriptional regulator	-
ETT67_RS08075	1577806..1578504	-	699	WP_023078900.1	hypothetical protein	-
ETT67_RS08080	1578640..1579500	-	861	WP_011529009.1	DegV family protein	-
ETT67_RS08085	1579597..1580115	-	519	WP_011055010.1	NYN domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-105)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 13171.97 Da
• Isoelectric Point: 5.2144

>T117785 WP_011018227.1 NZ_CP035432:1574967-1575302 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIISDIEKLEVFPEVGFDADEKYGSKIIHYHSTKGYTLSKD
YIVLYHIEGEENRVVIDYLLPTQSDYIKLFK

Nucleotide

• Length: 336 bp

>T117785 NZ_CP035432:1574967-1575302 [Streptococcus pyogenes]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCTCA
AAACTATTCCTCAACATCAGGTCAGCGTAAAATGGAGCAAATCATTAGCGACATAGAAAAACTCGAGGTTTTCCCAGAAG
TTGGTTTTGATGCCGATGAAAAATATGGTTCAAAAATCATCCATTATCACAGCACTAAAGGTTATACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAGGGGGAAGAAAATAGGGTCGTTATTGATTACTTGCTTCCTACTCAAAGCGACTATAT
AAAGTTATTCAAATAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10934.56 Da
• Isoelectric Point: 5.2318

>AT117785 WP_002988079.1 NZ_CP035432:1574690-1574977 [Streptococcus pyogenes]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Nucleotide

• Length: 288 bp

>AT117785 NZ_CP035432:1574690-1574977 [Streptococcus pyogenes]
ATGACTACAGTAAAAAAAAACAGAGCGGTTACCTTTCAAGCTAATAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCTGAAATCAACAAAAATATTGAGGATGTTCGTCAA
GGGAAGTTTTATACCTCTGAAGAAGTGAGGGCTGAACTTGGACTATAA

Structures

Toxin

• AlphaFold DB: A0A7Z2QKE7

Antitoxin

• AlphaFold DB: A0A4U7GX94