Detailed information of TA system TA117784

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelB(antitoxin)
• Location: 1561740..1562352
• Replicon: chromosome
• Accession: NZ_CP035431
• Organism: Streptococcus pyogenes strain emm105

Toxin (Protein)

• Gene name: parE
• Uniprot ID: Q5X9X8
• Locus tag: ETT68_RS07890
• Protein ID: WP_011018227.1
• Coordinates: 1562017..1562352 (+)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: Q5X9X9
• Locus tag: ETT68_RS07885
• Protein ID: WP_002988079.1
• Coordinates: 1561740..1562027 (+)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ETT68_RS07860	1556940..1557923	-	984	WP_002982755.1	tagatose-bisphosphate aldolase	-
ETT68_RS07865	1557927..1558856	-	930	WP_109991631.1	tagatose-6-phosphate kinase	-
ETT68_RS07870	1558902..1559417	-	516	WP_023612880.1	galactose-6-phosphate isomerase subunit LacB	-
ETT68_RS07875	1559452..1559880	-	429	WP_002982747.1	galactose-6-phosphate isomerase subunit LacA	-
ETT68_RS07880	1560317..1561090	+	774	WP_109991630.1	DeoR/GlpR family DNA-binding transcription regulator	-
ETT68_RS07885	1561740..1562027	+	288	WP_002988079.1	DNA-damage-inducible protein J	Antitoxin
ETT68_RS07890	1562017..1562352	+	336	WP_011018227.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
ETT68_RS09090	1562504..1562974	+	471	Protein_1446	integrase	-
ETT68_RS09095	1562937..1563299	+	363	WP_181394573.1	tyrosine-type recombinase/integrase	-
ETT68_RS09100	1563335..1563484	+	150	WP_011529006.1	integrase	-
ETT68_RS07915	1563616..1564008	-	393	WP_002982716.1	30S ribosomal protein S9	-
ETT68_RS07920	1564029..1564475	-	447	WP_002982710.1	50S ribosomal protein L13	-
ETT68_RS07925	1564693..1564899	-	207	WP_002982695.1	helix-turn-helix transcriptional regulator	-
ETT68_RS07930	1564896..1565594	-	699	WP_168688170.1	hypothetical protein	-
ETT68_RS07935	1565730..1566590	-	861	WP_011529009.1	DegV family protein	-
ETT68_RS07940	1566687..1567205	-	519	WP_002982682.1	NYN domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-105)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 13171.97 Da
• Isoelectric Point: 5.2144

>T117784 WP_011018227.1 NZ_CP035431:1562017-1562352 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIISDIEKLEVFPEVGFDADEKYGSKIIHYHSTKGYTLSKD
YIVLYHIEGEENRVVIDYLLPTQSDYIKLFK

Nucleotide

• Length: 336 bp

>T117784 NZ_CP035431:1562017-1562352 [Streptococcus pyogenes]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCTCA
AAACTATTCCTCAACATCAGGTCAGCGTAAAATGGAGCAAATCATTAGCGACATAGAAAAACTCGAGGTTTTCCCAGAAG
TTGGTTTTGATGCCGATGAAAAATATGGTTCAAAAATCATCCATTATCACAGCACTAAAGGTTATACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAGGGGGAAGAAAATAGGGTCGTTATTGATTACTTGCTTCCTACTCAAAGCGACTATAT
AAAGTTATTCAAATAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10934.56 Da
• Isoelectric Point: 5.2318

>AT117784 WP_002988079.1 NZ_CP035431:1561740-1562027 [Streptococcus pyogenes]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Nucleotide

• Length: 288 bp

>AT117784 NZ_CP035431:1561740-1562027 [Streptococcus pyogenes]
ATGACTACAGTAAAAAAAAACAGAGCGGTTACCTTTCAAGCTAATAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCTGAAATCAACAAAAATATTGAGGATGTTCGTCAA
GGGAAGTTTTATACCTCTGAAGAAGTGAGGGCTGAACTTGGACTATAA

Structures

Toxin

• AlphaFold DB: A0A7Z2QKE7

Antitoxin

• AlphaFold DB: A0A4U7GX94