Detailed information of TA system TA117783

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelB(antitoxin)
• Location: 1650577..1651189
• Replicon: chromosome
• Accession: NZ_CP035430
• Organism: Streptococcus pyogenes strain emm55

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: ETT69_RS08470
• Protein ID: WP_002994716.1
• Coordinates: 1650854..1651189 (+)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: Q5X9X9
• Locus tag: ETT69_RS08465
• Protein ID: WP_002988079.1
• Coordinates: 1650577..1650864 (+)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ETT69_RS08440	1645768..1646751	-	984	WP_136019499.1	tagatose-bisphosphate aldolase	-
ETT69_RS08445	1646755..1647684	-	930	WP_136019498.1	tagatose-6-phosphate kinase	-
ETT69_RS08450	1647730..1648245	-	516	WP_020905489.1	galactose-6-phosphate isomerase subunit LacB	-
ETT69_RS08455	1648280..1648708	-	429	WP_136019497.1	galactose-6-phosphate isomerase subunit LacA	-
ETT69_RS08460	1649154..1649927	+	774	WP_023605292.1	DeoR/GlpR family DNA-binding transcription regulator	-
ETT69_RS08465	1650577..1650864	+	288	WP_002988079.1	DNA-damage-inducible protein J	Antitoxin
ETT69_RS08470	1650854..1651189	+	336	WP_002994716.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
ETT69_RS08475	1651278..1652322	+	1045	Protein_1564	site-specific integrase	-
ETT69_RS08480	1652442..1652834	-	393	WP_002982716.1	30S ribosomal protein S9	-
ETT69_RS08485	1652855..1653301	-	447	WP_002982710.1	50S ribosomal protein L13	-
ETT69_RS08490	1653519..1653725	-	207	WP_109828617.1	helix-turn-helix transcriptional regulator	-
ETT69_RS08495	1653722..1654420	-	699	WP_168389128.1	hypothetical protein	-
ETT69_RS08500	1654556..1655416	-	861	WP_002982687.1	DegV family protein	-
ETT69_RS08505	1655513..1656031	-	519	WP_002982682.1	NYN domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (7-104)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 13154.89 Da
• Isoelectric Point: 5.6157

>T117783 WP_002994716.1 NZ_CP035430:1650854-1651189 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQHKMEQIISDIEKLEVFPEVGFDADEKYGSKISHYHSTKGYTLSKD
YIVLYHIEGEENRVVIDYLLPTRSDYIKLFK

Nucleotide

• Length: 336 bp

>T117783 NZ_CP035430:1650854-1651189 [Streptococcus pyogenes]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCTCA
AAACTATTCCTCAACATCAGGTCAGCATAAAATGGAGCAAATCATTAGCGACATAGAAAAACTCGAGGTTTTCCCAGAAG
TTGGTTTTGATGCTGATGAAAAATATGGTTCAAAAATCAGCCATTATCACAGCACTAAAGGTTACACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAGGGGGAAGAAAATAGGGTCGTTATTGATTACTTGCTTCCTACTCGAAGCGACTATAT
AAAGTTATTCAAATAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10934.56 Da
• Isoelectric Point: 5.2318

>AT117783 WP_002988079.1 NZ_CP035430:1650577-1650864 [Streptococcus pyogenes]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Nucleotide

• Length: 288 bp

>AT117783 NZ_CP035430:1650577-1650864 [Streptococcus pyogenes]
ATGACTACAGTAAAAAAAAACAGAGCGGTTACCTTTCAAGCTAATAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCTGAAATCAACAAAAATATTGAGGATGTTCGTCAA
GGGAAGTTTTATACCTCTGAAGAAGTGAGGGCTGAACTTGGACTATAA

Structures

Antitoxin

• AlphaFold DB: A0A4U7GX94