Detailed information of TA system TA117782

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelB(antitoxin)
• Location: 1544856..1545468
• Replicon: chromosome
• Accession: NZ_CP035429
• Organism: Streptococcus pyogenes strain emmNA

Toxin (Protein)

• Gene name: parE
• Uniprot ID: A0A4Z2JY48
• Locus tag: ETT70_RS08015
• Protein ID: WP_002982731.1
• Coordinates: 1545133..1545468 (+)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: Q5X9X9
• Locus tag: ETT70_RS08010
• Protein ID: WP_002988079.1
• Coordinates: 1544856..1545143 (+)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ETT70_RS07980	1540045..1541028	-	984	WP_011529001.1	tagatose-bisphosphate aldolase	-
ETT70_RS07985	1541032..1541961	-	930	WP_136275865.1	tagatose-6-phosphate kinase	-
ETT70_RS07990	1542009..1542524	-	516	WP_136275866.1	galactose-6-phosphate isomerase subunit LacB	-
ETT70_RS07995	1542559..1542987	-	429	WP_014635709.1	galactose-6-phosphate isomerase subunit LacA	-
ETT70_RS08000	1543433..1544206	+	774	WP_023605292.1	DeoR/GlpR family DNA-binding transcription regulator	-
ETT70_RS08010	1544856..1545143	+	288	WP_002988079.1	DNA-damage-inducible protein J	Antitoxin
ETT70_RS08015	1545133..1545468	+	336	WP_002982731.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
ETT70_RS09255	1545620..1546090	+	471	Protein_1470	integrase	-
ETT70_RS09260	1546452..1546601	+	150	WP_011285175.1	integrase	-
ETT70_RS08035	1546733..1547125	-	393	WP_002982716.1	30S ribosomal protein S9	-
ETT70_RS08040	1547146..1547592	-	447	WP_002982710.1	50S ribosomal protein L13	-
ETT70_RS08045	1547810..1548016	-	207	WP_002982695.1	helix-turn-helix transcriptional regulator	-
ETT70_RS08050	1548013..1548519	-	507	WP_002988070.1	hypothetical protein	-
ETT70_RS08055	1548655..1549515	-	861	WP_002982687.1	DegV family protein	-
ETT70_RS08060	1549612..1550130	-	519	WP_002982682.1	NYN domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-105)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 13145.88 Da
• Isoelectric Point: 5.2144

>T117782 WP_002982731.1 NZ_CP035429:1545133-1545468 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIISDIEKLEVFPEVGFDADEKYGSKISHYHSTKGYTLSKD
YIVLYHIEGEENRVVIDYLLPTQSDYIKLFK

Nucleotide

• Length: 336 bp

>T117782 NZ_CP035429:1545133-1545468 [Streptococcus pyogenes]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCTCA
AAACTACTCCTCAACATCAGGTCAGCGTAAAATGGAGCAAATCATTAGCGACATAGAAAAACTCGAGGTTTTCCCAGAAG
TTGGTTTTGATGCCGATGAAAAATATGGTTCAAAAATCAGTCATTATCACAGCACTAAAGGTTATACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAGGGGGAAGAAAATAGGGTCGTTATTGATTACTTGCTTCCTACTCAAAGCGACTATAT
AAAGTTATTCAAATAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10934.56 Da
• Isoelectric Point: 5.2318

>AT117782 WP_002988079.1 NZ_CP035429:1544856-1545143 [Streptococcus pyogenes]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Nucleotide

• Length: 288 bp

>AT117782 NZ_CP035429:1544856-1545143 [Streptococcus pyogenes]
ATGACTACAGTAAAAAAAAACAGAGCGGTTACCTTTCAAGCTAATAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCTGAAATCAACAAAAATATTGAGGATGTTCGTCAA
GGGAAGTTTTATACCTCTGAAGAAGTGAGGGCTGAACTTGGACTATAA

Structures

Toxin

• AlphaFold DB: A0A4Z2JY48

Antitoxin

• AlphaFold DB: A0A4U7GX94