Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 1616262..1616874 Replicon chromosome
Accession NZ_CP035427
Organism Streptococcus pyogenes strain emm74

Toxin (Protein)


Gene name parE Uniprot ID A0A4Z2JY48
Locus tag ETT72_RS08380 Protein ID WP_002982731.1
Coordinates 1616539..1616874 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q5X9X9
Locus tag ETT72_RS08375 Protein ID WP_002988079.1
Coordinates 1616262..1616549 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ETT72_RS08350 1611453..1612436 - 984 WP_032464565.1 tagatose-bisphosphate aldolase -
ETT72_RS08355 1612440..1613369 - 930 WP_032464566.1 tagatose-6-phosphate kinase -
ETT72_RS08360 1613415..1613930 - 516 WP_011285170.1 galactose-6-phosphate isomerase subunit LacB -
ETT72_RS08365 1613965..1614393 - 429 WP_011529004.1 galactose-6-phosphate isomerase subunit LacA -
ETT72_RS08370 1614839..1615612 + 774 WP_136292342.1 DeoR/GlpR family DNA-binding transcription regulator -
ETT72_RS08375 1616262..1616549 + 288 WP_002988079.1 DNA-damage-inducible protein J Antitoxin
ETT72_RS08380 1616539..1616874 + 336 WP_002982731.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ETT72_RS09665 1617026..1617496 + 471 Protein_1553 integrase -
ETT72_RS08395 1617459..1618007 + 549 WP_109828874.1 site-specific integrase -
ETT72_RS08400 1618127..1618519 - 393 WP_002982716.1 30S ribosomal protein S9 -
ETT72_RS08405 1618540..1618986 - 447 WP_002982710.1 50S ribosomal protein L13 -
ETT72_RS08410 1619204..1619410 - 207 WP_002982695.1 helix-turn-helix transcriptional regulator -
ETT72_RS08415 1619407..1619913 - 507 WP_002988070.1 hypothetical protein -
ETT72_RS08420 1620049..1620909 - 861 WP_002982687.1 DegV family protein -
ETT72_RS08425 1621006..1621524 - 519 WP_002982682.1 NYN domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-105)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 13145.88 Da        Isoelectric Point: 5.2144

>T117781 WP_002982731.1 NZ_CP035427:1616539-1616874 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIISDIEKLEVFPEVGFDADEKYGSKISHYHSTKGYTLSKD
YIVLYHIEGEENRVVIDYLLPTQSDYIKLFK

Download         Length: 336 bp

>T117781 NZ_CP035427:1616539-1616874 [Streptococcus pyogenes]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCTCA
AAACTACTCCTCAACATCAGGTCAGCGTAAAATGGAGCAAATCATTAGCGACATAGAAAAACTCGAGGTTTTCCCAGAAG
TTGGTTTTGATGCCGATGAAAAATATGGTTCAAAAATCAGTCATTATCACAGCACTAAAGGTTATACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAGGGGGAAGAAAATAGGGTCGTTATTGATTACTTGCTTCCTACTCAAAGCGACTATAT
AAAGTTATTCAAATAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10934.56 Da        Isoelectric Point: 5.2318

>AT117781 WP_002988079.1 NZ_CP035427:1616262-1616549 [Streptococcus pyogenes]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Download         Length: 288 bp

>AT117781 NZ_CP035427:1616262-1616549 [Streptococcus pyogenes]
ATGACTACAGTAAAAAAAAACAGAGCGGTTACCTTTCAAGCTAATAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCTGAAATCAACAAAAATATTGAGGATGTTCGTCAA
GGGAAGTTTTATACCTCTGAAGAAGTGAGGGCTGAACTTGGACTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4Z2JY48

Antitoxin

Source ID Structure
AlphaFold DB A0A4U7GX94

References