Detailed information of TA system TA117780

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelB(antitoxin)
• Location: 1529636..1530248
• Replicon: chromosome
• Accession: NZ_CP035426
• Organism: Streptococcus pyogenes strain emm57

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: ETT73_RS07820
• Protein ID: WP_014635711.1
• Coordinates: 1529913..1530248 (+)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: Q5X9X9
• Locus tag: ETT73_RS07815
• Protein ID: WP_002988079.1
• Coordinates: 1529636..1529923 (+)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ETT73_RS07790	1524824..1525807	-	984	WP_076634369.1	tagatose-bisphosphate aldolase	-
ETT73_RS07795	1525811..1526740	-	930	WP_076634370.1	tagatose-6-phosphate kinase	-
ETT73_RS07800	1526790..1527305	-	516	WP_014407849.1	galactose-6-phosphate isomerase subunit LacB	-
ETT73_RS07805	1527340..1527768	-	429	WP_014635709.1	galactose-6-phosphate isomerase subunit LacA	-
ETT73_RS07810	1528213..1528986	+	774	WP_136276778.1	DeoR/GlpR family DNA-binding transcription regulator	-
ETT73_RS07815	1529636..1529923	+	288	WP_002988079.1	DNA-damage-inducible protein J	Antitoxin
ETT73_RS07820	1529913..1530248	+	336	WP_014635711.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
ETT73_RS08935	1530400..1530822	+	423	Protein_1415	integrase	-
ETT73_RS08940	1531218..1531367	+	150	WP_186794715.1	hypothetical protein	-
ETT73_RS07835	1531487..1531879	-	393	WP_002982716.1	30S ribosomal protein S9	-
ETT73_RS07840	1531900..1532346	-	447	WP_002982710.1	50S ribosomal protein L13	-
ETT73_RS07845	1532564..1532770	-	207	WP_002982695.1	helix-turn-helix transcriptional regulator	-
ETT73_RS07850	1532767..1533465	-	699	WP_186794716.1	hypothetical protein	-
ETT73_RS07855	1533601..1534461	-	861	WP_011529009.1	DegV family protein	-
ETT73_RS07860	1534558..1535076	-	519	WP_136276780.1	NYN domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-106)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 13173.94 Da
• Isoelectric Point: 5.6809

>T117780 WP_014635711.1 NZ_CP035426:1529913-1530248 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIISDIEKLEVFPEVGFDADEKYGSKISHYHSTKGYTLSKD
YIVLYHIEGEENRVVIDYLLPTRSDYIKLFK

Nucleotide

• Length: 336 bp

>T117780 NZ_CP035426:1529913-1530248 [Streptococcus pyogenes]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGGGATTATATTTCTCA
AAACTATTCCTCAACATCAGGTCAGCGTAAAATGGAGCAAATCATTAGCGACATAGAAAAACTCGAGGTTTTCCCAGAAG
TTGGTTTTGATGCCGATGAAAAATATGGTTCAAAAATCAGCCATTATCACAGCACTAAAGGTTACACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAGGGGGAAGAAAATAGGGTCGTTATTGATTACTTGCTTCCTACTCGAAGCGACTATAT
AAAGTTATTCAAATAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10934.56 Da
• Isoelectric Point: 5.2318

>AT117780 WP_002988079.1 NZ_CP035426:1529636-1529923 [Streptococcus pyogenes]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Nucleotide

• Length: 288 bp

>AT117780 NZ_CP035426:1529636-1529923 [Streptococcus pyogenes]
ATGACTACAGTAAAAAAAAACAGAGCGGTTACCTTTCAAGCTAATAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCTGAAATCAACAAAAATATTGAGGATGTTCGTCAA
GGGAAGTTTTATACCTCTGAAGAAGTGAGGGCTGAACTTGGACTATAA

Structures

Antitoxin

• AlphaFold DB: A0A4U7GX94