117760

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 576334..576970 Replicon chromosome
Accession NZ_CP035404
Organism Bacillus licheniformis strain SRCM103583

Toxin (Protein)


Gene name mazF Uniprot ID M5P3Q9
Locus tag ETA57_RS02860 Protein ID WP_003179128.1
Coordinates 576620..576970 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID M5PDU2
Locus tag ETA57_RS02855 Protein ID WP_006638778.1
Coordinates 576334..576615 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ETA57_RS02835 571449..572930 + 1482 WP_009330132.1 PH domain-containing protein -
ETA57_RS02840 572927..573526 - 600 WP_003179118.1 rhomboid family intramembrane serine protease -
ETA57_RS02845 573869..574828 + 960 WP_164972526.1 outer membrane lipoprotein carrier protein LolA -
ETA57_RS02850 575053..576222 + 1170 WP_025807384.1 alanine racemase -
ETA57_RS02855 576334..576615 + 282 WP_006638778.1 hypothetical protein Antitoxin
ETA57_RS02860 576620..576970 + 351 WP_003179128.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
ETA57_RS02865 577088..577915 + 828 WP_003179130.1 RsbT co-antagonist protein RsbRA -
ETA57_RS02870 577919..578284 + 366 WP_003179132.1 STAS domain-containing protein -
ETA57_RS02875 578287..578688 + 402 WP_003179135.1 anti-sigma regulatory factor -
ETA57_RS02880 578699..579706 + 1008 WP_003179137.1 PP2C family protein-serine/threonine phosphatase -
ETA57_RS02885 579765..580091 + 327 WP_003179140.1 anti-sigma factor antagonist -
ETA57_RS02890 580091..580576 + 486 WP_003179142.1 anti-sigma B factor RsbW -
ETA57_RS02895 580542..581333 + 792 WP_003179144.1 RNA polymerase sigma factor SigB -
ETA57_RS02900 581330..581929 + 600 WP_003179145.1 SpoIIE family protein phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12990.03 Da        Isoelectric Point: 5.7234

>T117760 WP_003179128.1 NZ_CP035404:576620-576970 [Bacillus licheniformis]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNNIGNRFSPTAIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMEKVNEALQISLALIDF

Download         Length: 351 bp

>T117760 NZ_CP035404:576620-576970 [Bacillus licheniformis]
TTGATTGTTAAACGCGGCGATGTTTATTTTGCTGACCTATCTCCTGTTGTTGGCTCAGAACAAGGCGGGGTGCGCCCGGT
TTTAGTGATTCAAAACAACATCGGCAATCGCTTCAGCCCAACTGCTATTGTTGCAGCCATAACAGCCCAAATACAGAAAG
CAAAATTACCTACCCACGTCGAAATTGATGCGAAACGCTACGGTTTTGAAAGAGACTCCGTTATATTGCTCGAACAAATT
CGGACGATTGACAAGCAAAGATTAACGGACAAAATCACCCATCTCGATGATGAAATGATGGAAAAGGTCAACGAAGCCTT
ACAAATCAGTTTGGCACTCATTGATTTTTAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10649.03 Da        Isoelectric Point: 4.6920

>AT117760 WP_006638778.1 NZ_CP035404:576334-576615 [Bacillus licheniformis]
MSESSATTEILIRLPEALVSELDGVVMQDNGSRNELIYQATKMYLRERKNRQIRESMRRGYMEMAKINLNISSEAQFAEY
EAENTVERLVSGG

Download         Length: 282 bp

>AT117760 NZ_CP035404:576334-576615 [Bacillus licheniformis]
TTGTCTGAATCCAGCGCAACAACTGAAATATTGATTCGCTTGCCAGAAGCTTTAGTATCAGAACTGGATGGTGTCGTCAT
GCAAGATAACGGGAGCAGAAATGAACTGATTTACCAAGCCACAAAAATGTATTTACGCGAACGCAAAAATCGACAAATTC
GGGAATCGATGAGACGCGGTTATATGGAGATGGCCAAGATCAATTTGAACATCTCTTCTGAGGCTCAATTTGCAGAGTAT
GAGGCTGAAAACACAGTAGAGCGCTTAGTAAGCGGAGGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6I7FHI4

Antitoxin

Source ID Structure
AlphaFold DB M5PDU2

References