Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PhRel2-ATphRel2/DUF4065(antitoxin)
Location 733419..734875 Replicon chromosome
Accession NZ_CP035403
Organism Bacillus subtilis strain SRCM103581

Toxin (Protein)


Gene name phRel2 Uniprot ID -
Locus tag ETA15_RS03935 Protein ID WP_129093280.1
Coordinates 733419..734120 (+) Length 234 a.a.

Antitoxin (Protein)


Gene name ATphRel2 Uniprot ID -
Locus tag ETA15_RS03940 Protein ID WP_038428497.1
Coordinates 734126..734875 (+) Length 250 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ETA15_RS03895 729617..730021 + 405 WP_129093276.1 hypothetical protein -
ETA15_RS03900 730182..730352 + 171 WP_129093277.1 XkdX family protein -
ETA15_RS03905 730364..730621 + 258 WP_129093278.1 hypothetical protein -
ETA15_RS03910 730708..730977 + 270 WP_074794633.1 hemolysin XhlA family protein -
ETA15_RS03915 730993..731256 + 264 WP_129093279.1 phage holin -
ETA15_RS03920 731314..732249 + 936 WP_114523751.1 N-acetylmuramoyl-L-alanine amidase -
ETA15_RS21995 732536..732679 + 144 WP_015715414.1 hypothetical protein -
ETA15_RS03925 732742..732951 + 210 WP_174243448.1 hypothetical protein -
ETA15_RS03930 732929..733159 + 231 WP_038428494.1 DNA-binding protein -
ETA15_RS03935 733419..734120 + 702 WP_129093280.1 hypothetical protein Toxin
ETA15_RS03940 734126..734875 + 750 WP_038428497.1 DUF4065 domain-containing protein Antitoxin
ETA15_RS03945 734905..735093 - 189 WP_038428499.1 hypothetical protein -
ETA15_RS03955 736473..737492 + 1020 WP_017697430.1 hypothetical protein -
ETA15_RS22000 737942..738109 + 168 WP_017697432.1 hypothetical protein -
ETA15_RS03960 738091..739128 + 1038 WP_129093281.1 teicoplanin resistance protein VanZ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - groEL 689440..734875 45435


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin SocA-like, Panacea domain

(113-225)


Sequences

Toxin        


Download         Length: 234 a.a.        Molecular weight: 27990.66 Da        Isoelectric Point: 6.5777

>T117758 WP_129093280.1 NZ_CP035403:733419-734120 [Bacillus subtilis]
MIKCTCEIESFCNDLHELILEINQLHNDFSTEFSLNKDVKHFNLRKKQIRHITEVTEKKGLFSIDNDFFISLQHYAEKLE
NVVIYNDLEYLYSDFDLRLRVKQPDSIVNKLKYYRVGKLESGQIPLRKCLNDLLGMRITIDSFDHNNDCFQNICDLLMNQ
YRINCMDSSKGDYKAFHFYFYGESNTFFPWELQIWRTEDKEANNRSHQLHKQEYTNWASIYKNSTETSVEKKR

Download         Length: 702 bp

>T117758 NZ_CP035403:733419-734120 [Bacillus subtilis]
TTGATTAAATGCACTTGTGAAATCGAGTCATTTTGCAATGATCTTCATGAGTTGATACTAGAAATTAATCAGTTGCATAA
TGATTTTTCAACCGAATTCAGCTTAAATAAAGATGTAAAGCATTTTAACTTAAGAAAGAAACAAATAAGACATATTACAG
AGGTAACTGAAAAGAAGGGTCTTTTCTCAATCGATAATGATTTTTTTATTTCACTTCAACATTACGCTGAAAAACTAGAA
AATGTTGTCATCTATAATGACTTGGAGTATCTATATAGCGACTTTGACTTGCGCCTTAGAGTAAAACAACCAGATTCGAT
TGTCAATAAGCTAAAGTATTATCGTGTTGGAAAGCTCGAGAGCGGGCAAATACCTTTAAGAAAGTGCTTGAATGATTTGT
TGGGAATGAGAATAACAATTGATTCTTTTGACCATAATAATGACTGTTTTCAGAATATCTGTGACTTATTGATGAACCAA
TACAGAATAAATTGTATGGATTCATCAAAGGGTGATTATAAAGCATTTCATTTTTATTTTTATGGTGAAAGTAATACCTT
TTTTCCTTGGGAGCTTCAAATTTGGAGAACTGAAGATAAAGAAGCAAATAATCGATCTCACCAACTTCACAAACAAGAAT
ATACAAATTGGGCATCGATTTATAAAAACTCTACAGAAACATCTGTGGAGAAAAAGAGGTGA

Antitoxin


Download         Length: 250 a.a.        Molecular weight: 28913.17 Da        Isoelectric Point: 6.9679

>AT117758 WP_038428497.1 NZ_CP035403:734126-734875 [Bacillus subtilis]
MAFHFIAIISDFSGGRRIGWHYSSEERLDKNYISEFFERVKEKCGKVQFGIHKLSTDSTSWNSVTEKDSFFEDVIVTEDI
TSFIDVISKDKELTAYDVAKFVLSFQPSSHLKLQKLLYYIYAEFLLKTGKKLFREPIVAFKYGPVIEDIFFKYKRHGKSI
IDYREDANIKLLTDDLVVTPTFMKVLSSEHGLEAIECITKVLVKYGKHAPFRLVDMTHQEGGPWKRAYEPGQNCVITDEL
ITQYHQYAT

Download         Length: 750 bp

>AT117758 NZ_CP035403:734126-734875 [Bacillus subtilis]
ATGGCATTTCATTTTATCGCGATTATTAGTGATTTTTCTGGTGGTAGAAGAATTGGCTGGCACTATTCGAGCGAGGAAAG
ATTGGATAAAAACTACATTTCCGAATTCTTTGAAAGAGTTAAGGAAAAATGTGGTAAGGTTCAATTTGGAATTCACAAAT
TATCAACTGATTCAACTAGCTGGAATTCTGTCACTGAGAAAGATTCCTTTTTTGAGGATGTTATTGTGACAGAGGATATT
ACCTCCTTTATAGATGTAATATCAAAAGACAAGGAATTAACCGCATATGATGTGGCAAAATTTGTTTTGTCCTTTCAACC
ATCCTCACACTTAAAATTGCAAAAATTGTTATATTATATTTATGCTGAGTTTTTATTAAAAACGGGGAAAAAGCTATTCA
GAGAACCCATAGTAGCGTTTAAATATGGCCCTGTTATCGAGGATATTTTCTTTAAATATAAGAGACATGGGAAATCTATA
ATAGATTATCGAGAGGACGCTAACATAAAACTTCTTACTGATGATTTGGTGGTAACGCCGACATTCATGAAGGTTTTGTC
TTCTGAGCATGGACTAGAAGCTATAGAATGTATTACAAAAGTGCTTGTTAAATACGGAAAGCATGCACCTTTCCGTTTAG
TTGATATGACTCATCAAGAAGGTGGACCTTGGAAAAGAGCATACGAGCCAGGTCAAAATTGTGTAATAACAGATGAACTT
ATTACTCAGTATCACCAATATGCTACGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References