Detailed information of TA system TA117727

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 3833435..3834092
• Replicon: chromosome
• Accession: NZ_CP035385
• Organism: Enterobacter hormaechei strain S11_16

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: EQ802_RS18745
• Protein ID: WP_063147416.1
• Coordinates: 3833435..3833845 (-)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: G8LDB7
• Locus tag: EQ802_RS18750
• Protein ID: WP_003863437.1
• Coordinates: 3833826..3834092 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EQ802_RS18725	3829433..3831166	-	1734	WP_048965620.1	single-stranded-DNA-specific exonuclease RecJ	-
EQ802_RS18730	3831172..3831885	-	714	WP_022649304.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
EQ802_RS18735	3831914..3832810	-	897	WP_048965619.1	site-specific tyrosine recombinase XerD	-
EQ802_RS18740	3832912..3833433	+	522	WP_015571793.1	flavodoxin FldB	-
EQ802_RS18745	3833435..3833845	-	411	WP_063147416.1	protein YgfX	Toxin
EQ802_RS18750	3833826..3834092	-	267	WP_003863437.1	FAD assembly factor SdhE	Antitoxin
EQ802_RS18755	3834387..3835367	+	981	WP_063147415.1	tRNA-modifying protein YgfZ	-
EQ802_RS18760	3835888..3836547	-	660	WP_022649307.1	hemolysin III family protein	-
EQ802_RS18765	3836814..3837545	+	732	WP_022649308.1	MurR/RpiR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-132)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 16317.22 Da
• Isoelectric Point: 11.4775

>T117727 WP_063147416.1 NZ_CP035385:c3833845-3833435 [Enterobacter hormaechei]
VVLWQSDLRVSWRSQWMSLLLHGLVAAMVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMIGTPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPPQE

Nucleotide

• Length: 411 bp

>T117727 NZ_CP035385:c3833845-3833435 [Enterobacter hormaechei]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCGTGGCGCTCACAGTGGATGTCCTTACTGCTCCACGGTCTGGTCGCGGC
AATGGTGTTATTGGTGCCGTGGCCGCTAAGCTATACCCCTCTGTGGCTGCTTTTGCTGTCGTTTGTAGTGTTTGACAGCG
TGCGCAGCCAGCGTCGAATCAACGCCCGTCAGGGTGAAATTAAGCTGCTGATGGATTCTCGCCTGCGCTGGCAGGGAAAA
GAGTGGGAAATGATAGGGACGCCGTGGATGCTCAACACCGGGATGATGCTACGGCTGCGTCGGGTCGAGGACAATCGTCG
CCAGCACCTGTGGCTGGCAGCAGACAGTATGGATCCTGCGGAGTGGCGAGATCTGCGCCGGTTGATCGTGCAACAGCCGC
CGCAGGAGTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10526.96 Da
• Isoelectric Point: 4.8310

>AT117727 WP_003863437.1 NZ_CP035385:c3834092-3833826 [Enterobacter hormaechei]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Nucleotide

• Length: 267 bp

>AT117727 NZ_CP035385:c3834092-3833826 [Enterobacter hormaechei]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGCATGCGTGAACTTGATATCTCCATCATGCCTTT
CTTCGAGTATGAGTACGACAGCTTAAGCGATGACGATAAGCGCCTGTTTGTCCGTCTGCTTGAGTCCGACGATCCGGATT
TATTCAACTGGCTGATGAATCACGGCAAGCCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CAGGAACGTGGTCCTGTGGCAATCTGA

Structures

Antitoxin

• AlphaFold DB: A0A837F8P5