Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2363055..2363794 Replicon chromosome
Accession NZ_CP035385
Organism Enterobacter hormaechei strain S11_16

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag EQ802_RS11695 Protein ID WP_063139083.1
Coordinates 2363055..2363540 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID -
Locus tag EQ802_RS11700 Protein ID WP_046621516.1
Coordinates 2363528..2363794 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EQ802_RS11665 2358414..2359172 + 759 WP_063147324.1 DeoR/GlpR family DNA-binding transcription regulator -
EQ802_RS11670 2359277..2360569 + 1293 WP_063147323.1 glycoside hydrolase -
EQ802_RS11680 2361220..2362023 + 804 WP_063147321.1 DUF4225 domain-containing protein -
EQ802_RS11685 2361998..2362327 - 330 WP_023306210.1 hypothetical protein -
EQ802_RS11690 2362460..2363029 + 570 WP_063147320.1 hypothetical protein -
EQ802_RS11695 2363055..2363540 - 486 WP_063139083.1 GNAT family N-acetyltransferase Toxin
EQ802_RS11700 2363528..2363794 - 267 WP_046621516.1 DUF1778 domain-containing protein Antitoxin
EQ802_RS11705 2363858..2364787 - 930 WP_063147319.1 LysR family transcriptional regulator -
EQ802_RS11710 2364917..2366305 + 1389 WP_063147318.1 MFS transporter -
EQ802_RS11715 2366284..2366841 - 558 WP_023300131.1 OmpH family outer membrane protein -
EQ802_RS11720 2366962..2368098 - 1137 WP_063147317.1 type 1 fimbrial protein -
EQ802_RS11725 2368122..2368646 - 525 WP_087878309.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2347585..2363794 16209


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(58-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17544.22 Da        Isoelectric Point: 9.6275

>T117718 WP_063139083.1 NZ_CP035385:c2363540-2363055 [Enterobacter hormaechei]
VGRVTPPEPLSSVHQLAEFVSGEAVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDVSIRGNGLGADLLQDAVLRCYRVAENIGVRAIMVHALTEDAKAFYIHHGFKASQTQERTLFLRLP
Q

Download         Length: 486 bp

>T117718 NZ_CP035385:c2363540-2363055 [Enterobacter hormaechei]
GTGGGACGTGTAACCCCCCCAGAGCCCTTATCCAGCGTCCATCAACTGGCGGAGTTCGTCAGTGGAGAGGCCGTACTTGA
CGAATGGTTAAAACAAAGAGGTCTGAAAAACCAGGCGCTTGGCGCAGCCCGAACGTTTGTCGTTTGTAAAACGGGCACAA
AGCAGGTCGCGGGATTTTACTCTCTGGCTACCGGCAGCGTTAACCATACGGAAGCGACAGGTAATTTGCGGCGTAACATG
CCGGATCCCATTCCCGTGATTATTCTCGCCCGTCTGGCTGTCGATGTCTCAATACGCGGAAATGGGTTGGGAGCCGATTT
ACTCCAGGATGCGGTTTTACGCTGTTATCGGGTAGCAGAGAATATTGGGGTGCGGGCGATCATGGTTCATGCACTCACTG
AGGACGCCAAAGCGTTTTATATCCACCATGGTTTTAAAGCATCGCAGACTCAGGAACGGACACTGTTTCTCAGGCTTCCG
CAGTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10089.51 Da        Isoelectric Point: 4.4857

>AT117718 WP_046621516.1 NZ_CP035385:c2363794-2363528 [Enterobacter hormaechei]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNNEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWDV

Download         Length: 267 bp

>AT117718 NZ_CP035385:c2363794-2363528 [Enterobacter hormaechei]
ATGAAATCAGATGTTCAACTCAATCTTAGAGCCAAAGAATCCCAGCGGGCGCTTATCGATGCCGCCGCAGAGATCCTCCA
TAAATCACGTACTGACTTCATTCTGGAGATGGCCTGTCAGGCAGCCGAAAATGTGATCCTCGATCGGCGTGTATTCAATT
TTAACAATGAACAGTATGCAGAGTTCATTGATATGCTCGATGCCCCGGTCGCCGACGATCCTGCCATAGAAAAACTGCTG
GCAAGGAAACCTCAGTGGGACGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References