Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1070687..1071308 Replicon chromosome
Accession NZ_CP035385
Organism Enterobacter hormaechei strain S11_16

Toxin (Protein)


Gene name Hha Uniprot ID A0A837FFM2
Locus tag EQ802_RS05110 Protein ID WP_015571250.1
Coordinates 1070687..1070905 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID F5RUW7
Locus tag EQ802_RS05115 Protein ID WP_006809850.1
Coordinates 1070934..1071308 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EQ802_RS05080 1066699..1066959 + 261 WP_015571255.1 type B 50S ribosomal protein L31 -
EQ802_RS05085 1066962..1067102 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
EQ802_RS05090 1067099..1067809 - 711 WP_046620525.1 GNAT family N-acetyltransferase -
EQ802_RS05095 1067912..1069372 + 1461 WP_023299463.1 PLP-dependent aminotransferase family protein -
EQ802_RS05100 1069344..1069811 - 468 WP_022647269.1 hypothetical protein -
EQ802_RS05105 1069928..1070479 - 552 WP_023305596.1 maltose O-acetyltransferase -
EQ802_RS05110 1070687..1070905 - 219 WP_015571250.1 hemolysin expression modulator Hha Toxin
EQ802_RS05115 1070934..1071308 - 375 WP_006809850.1 Hha toxicity modulator TomB Antitoxin
EQ802_RS05120 1071818..1074964 - 3147 WP_023299464.1 multidrug efflux RND transporter permease subunit -
EQ802_RS05125 1074987..1076180 - 1194 WP_022647272.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8583.95 Da        Isoelectric Point: 8.9008

>T117716 WP_015571250.1 NZ_CP035385:c1070905-1070687 [Enterobacter hormaechei]
MSDKPLTKVDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR

Download         Length: 219 bp

>T117716 NZ_CP035385:c1070905-1070687 [Enterobacter hormaechei]
ATGTCTGATAAACCATTAACTAAAGTCGATTATTTGATGCGCCTGCGACGCTGTCAGTCAATTGACACGCTCGAACGTGT
TATTGAGAAAAATAAATACGAGCTGTCTGATAATGAACTGGCGGTATTTTATTCAGCTGCCGACCATCGTCTTGCTGAAC
TGACCATGAATAAACTCTATGACAAGATCCCCTCTTCGGTATGGAAATTTGTTCGTTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14497.28 Da        Isoelectric Point: 4.8989

>AT117716 WP_006809850.1 NZ_CP035385:c1071308-1070934 [Enterobacter hormaechei]
MDEYSPKRHDIAQLKFLCESLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFTNVSRANPVSLSC

Download         Length: 375 bp

>AT117716 NZ_CP035385:c1071308-1070934 [Enterobacter hormaechei]
ATGGACGAGTACTCGCCAAAAAGGCATGATATCGCGCAGTTGAAATTTCTCTGCGAATCCTTGTACCATGACTGCCTTGC
CAATCTTGAAGAAAGTAACCATGGCTGGGTGAACGATCCAACGTCTGCGATCAATTTACAGCTTAATGAGCTGATCGAGC
ATATCGCAACCTTCGCACTTAATTATAAAATTAAGTACAATGAAGATAATAAGTTGATAGAGCAAATTGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTACGGCATTAACGCACAGGATTTGCAGAAATGGCGTAAATCAGGAAACCGTCT
ATTTCGCTGCTTCACGAATGTCAGCAGAGCTAATCCGGTTAGTCTTTCCTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FFM2

Antitoxin

Source ID Structure
AlphaFold DB A0A837FGN8

References