Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 84571..86197 Replicon plasmid pAP855
Accession NZ_CP035384
Organism Klebsiella pneumoniae strain AP8555

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag ES964_RS27380 Protein ID WP_104466651.1
Coordinates 84872..86197 (+) Length 442 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag ES964_RS27375 Protein ID WP_104466664.1
Coordinates 84571..84867 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ES964_RS27345 80106..80864 - 759 WP_104466646.1 Tat pathway signal sequence -
ES964_RS27350 80918..81838 - 921 WP_104466647.1 hypothetical protein -
ES964_RS27355 81902..82273 - 372 WP_032676621.1 hypothetical protein -
ES964_RS27360 82415..83101 - 687 WP_104466648.1 transmembrane anchor protein -
ES964_RS27365 83115..83852 - 738 WP_104466649.1 HupE/UreJ family protein -
ES964_RS27370 83896..84261 - 366 WP_104466650.1 hypothetical protein -
ES964_RS27375 84571..84867 + 297 WP_104466664.1 helix-turn-helix transcriptional regulator Antitoxin
ES964_RS27380 84872..86197 + 1326 WP_104466651.1 type II toxin-antitoxin system HipA family toxin Toxin
ES964_RS27385 86440..86613 - 174 Protein_105 IS481 family transposase -
ES964_RS27395 88044..88289 + 246 WP_001568063.1 helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - iroB / iroC / iroD / iroN / rmpA / iucA / iucB / iucC / iucD / iutA / rmpA2 1..357837 357837


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(8-108)

Antitoxin

Cro/C1-type helix-turn-helix domain

(20-69)


Sequences

Toxin        


Download         Length: 442 a.a.        Molecular weight: 50315.38 Da        Isoelectric Point: 6.0973

>T117711 WP_104466651.1 NZ_CP035384:84872-86197 [Klebsiella pneumoniae]
MVRKQQRLAIWMNGIQVGFWEKSKGDDSLRYLTEWVADEQGRPLSLSLPFTPGNQILHGNVVRDYFDNLLPDSEGIRRRL
AMRYQADSLEPFDLLKELGKDCVGAIQLLSDEEEPTDLYSVKYRPLSESEIASTLRNTTEALLPGRHVDNDDLRLSIAGA
QEKTALLWHDGSWCLPLGHTPTTHIFKLPLGLVGNMKADMSTSVENEWLCSLLLEQYGVPVAKTQIAQFEDQKALVVERF
DRRWSGDQQWIIRLPQEDMCQALAVSPLRKYQADGGPGISDIMGILSHSDRAEHDRIQFFRAQILFWLMAATDGHAKNFS
IAIEPRGQYHLTPLYDVLSAWPIIGNGNAQISWQKCKLAMAIRGSSNYYQIYRILRRHWIKHGELTGLSRQQVETMIDDI
VAVTPEVIERVYAQLPAHFPQELAESVFDGMRQQCRRLSEK

Download         Length: 1326 bp

>T117711 NZ_CP035384:84872-86197 [Klebsiella pneumoniae]
ATGGTCAGGAAACAGCAACGTTTAGCGATATGGATGAACGGCATTCAGGTCGGGTTCTGGGAAAAGAGTAAAGGCGATGA
TTCGTTACGATATCTCACTGAATGGGTTGCTGACGAACAAGGCCGGCCATTGTCTTTGTCCCTGCCTTTCACACCCGGCA
ACCAAATTTTGCACGGTAACGTAGTACGTGATTATTTTGATAATTTACTGCCGGATAGTGAAGGGATCCGCAGGCGTCTG
GCAATGCGCTATCAGGCAGACAGTCTCGAACCTTTCGACCTGTTGAAGGAGTTGGGAAAAGACTGCGTTGGGGCAATACA
GCTACTGAGTGATGAAGAGGAACCCACTGATTTATATTCAGTAAAATATCGTCCTCTTTCTGAATCAGAAATCGCGTCAA
CATTACGAAATACGACGGAAGCTTTACTACCCGGCAGGCATGTCGATAATGATGACTTACGATTATCGATTGCCGGTGCG
CAGGAAAAAACAGCTTTACTGTGGCATGACGGCAGTTGGTGTCTGCCTCTGGGTCATACACCGACGACTCATATTTTCAA
GTTACCGCTCGGGCTGGTCGGGAATATGAAAGCAGATATGAGTACGTCAGTAGAAAATGAATGGCTCTGTTCGTTGCTTC
TTGAGCAATACGGGGTCCCTGTCGCCAAAACCCAGATTGCTCAATTTGAAGATCAGAAGGCTCTGGTGGTGGAACGTTTT
GACCGAAGATGGTCAGGAGACCAGCAGTGGATCATTCGCTTACCCCAGGAGGATATGTGCCAGGCTCTCGCGGTATCACC
ATTACGGAAATACCAGGCCGATGGCGGGCCAGGGATCTCTGACATTATGGGTATTCTGAGTCATTCAGACCGGGCTGAAC
ATGACAGAATACAGTTCTTCAGGGCTCAGATTCTTTTCTGGCTTATGGCCGCTACAGATGGCCACGCCAAAAATTTCAGT
ATCGCGATAGAGCCTCGCGGACAGTATCATCTTACTCCGCTCTATGATGTTTTATCGGCATGGCCAATTATTGGCAACGG
AAACGCACAGATTTCCTGGCAGAAATGCAAACTGGCGATGGCAATCCGTGGCAGCAGTAACTATTACCAGATTTACAGAA
TATTAAGACGCCACTGGATCAAACATGGTGAGTTGACTGGTCTGAGCAGGCAGCAGGTCGAAACGATGATTGATGACATT
GTAGCCGTGACGCCAGAGGTTATTGAACGTGTCTACGCACAACTTCCAGCTCACTTCCCACAAGAACTTGCTGAGAGTGT
TTTTGATGGAATGAGGCAGCAGTGCAGGCGTCTGAGCGAGAAATAG

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 10997.65 Da        Isoelectric Point: 10.3740

>AT117711 WP_104466664.1 NZ_CP035384:84571-84867 [Klebsiella pneumoniae]
MKNVYPIRTLNQLRPLLLGFRKANGLTQKDVSERLGVTQQTYARLEANPASASIERLFKVFTVLGVEISLSSVKGSSEMM
QSGENESLESLPARREKW

Download         Length: 297 bp

>AT117711 NZ_CP035384:84571-84867 [Klebsiella pneumoniae]
ATGAAAAATGTTTATCCAATAAGAACACTCAACCAGTTGCGTCCATTGCTGCTTGGATTTCGCAAAGCGAATGGACTGAC
TCAAAAAGACGTTTCTGAGCGGTTAGGCGTAACCCAGCAGACTTACGCTCGCCTGGAGGCCAATCCAGCCAGTGCGAGTA
TTGAACGCCTGTTCAAAGTGTTTACCGTGCTGGGAGTGGAAATCAGCCTTTCCTCGGTGAAAGGTTCATCAGAAATGATG
CAGTCGGGTGAAAATGAATCTTTGGAAAGTTTGCCTGCCAGACGGGAGAAATGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References