Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4916199..4916715 Replicon chromosome
Accession NZ_CP035383
Organism Klebsiella pneumoniae strain AP8555

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag ES964_RS24095 Protein ID WP_004178374.1
Coordinates 4916199..4916483 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag ES964_RS24100 Protein ID WP_002886901.1
Coordinates 4916473..4916715 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ES964_RS24075 4911595..4911903 - 309 WP_012737232.1 PTS sugar transporter subunit IIB -
ES964_RS29800 4911988..4912161 + 174 WP_041169004.1 hypothetical protein -
ES964_RS24080 4912164..4912907 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
ES964_RS24085 4913264..4915402 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
ES964_RS24090 4915731..4916195 + 465 WP_004222151.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
ES964_RS24095 4916199..4916483 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ES964_RS24100 4916473..4916715 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
ES964_RS24105 4916793..4918703 - 1911 WP_012737231.1 BglG family transcription antiterminator -
ES964_RS24110 4918726..4919880 - 1155 WP_012737230.1 lactonase family protein -
ES964_RS24115 4919947..4920687 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T117708 WP_004178374.1 NZ_CP035383:c4916483-4916199 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T117708 NZ_CP035383:c4916483-4916199 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT117708 WP_002886901.1 NZ_CP035383:c4916715-4916473 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT117708 NZ_CP035383:c4916715-4916473 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References