Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 4069954..4071528 Replicon chromosome
Accession NZ_CP035382
Organism Leclercia adecarboxylata strain R25

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag ES815_RS20410 Protein ID WP_142489447.1
Coordinates 4069954..4071273 (-) Length 440 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag ES815_RS20415 Protein ID WP_142489448.1
Coordinates 4071277..4071528 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ES815_RS20395 4065479..4066660 - 1182 WP_142489444.1 PLP-dependent aminotransferase family protein -
ES815_RS20400 4066760..4068754 - 1995 WP_142489445.1 TonB-dependent receptor -
ES815_RS20405 4068765..4069826 - 1062 WP_142489446.1 YncE family protein -
ES815_RS20410 4069954..4071273 - 1320 WP_142489447.1 type II toxin-antitoxin system HipA family toxin Toxin
ES815_RS20415 4071277..4071528 - 252 WP_142489448.1 helix-turn-helix domain-containing protein Antitoxin
ES815_RS20420 4072334..4076134 + 3801 WP_142489449.1 glycosyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(6-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(10-64)


Sequences

Toxin        


Download         Length: 440 a.a.        Molecular weight: 48603.00 Da        Isoelectric Point: 6.9657

>T117684 WP_142489447.1 NZ_CP035382:c4071273-4069954 [Leclercia adecarboxylata]
MRAKRLTVAMNGDVIGTLHRDGSGAMSFQYAPAWLAEPGSRAISLSLPLQHGRISGAPVFNFFSNLLPDSEAIIARMQAR
FQVETTHPFDLLASVGRDCVGAIQLYPPGQEIPPVTDIVAEPLDDDQIAALLEGYQMAPLGMTEEGADFRISLAGAQEKT
ALLWYQDRWQRPQGSTPTSHIFKLPIGRIEQNNIDLSESCENEWLCLRIAKAFGFPVAHADMAQFGRKKVLIIERFDRRW
ARSGWLMRLPQEDFCQALGVSPALKYESHGGPGIADAMKLLLGSRLAGQDREMFFKAQILFWMLAAIDGHGKNFSLFIEA
DSSFRMAPLYDVISAFPLFDAGGIPIKKAKMAMALQGKNRQYHFAMIQPRHFISTAAFAGFSQEAARRLMTEMAAVTDDV
IATVRAELPTDFPLPVSEAIFRGLARQAARIGRFNELTP

Download         Length: 1320 bp

>T117684 NZ_CP035382:c4071273-4069954 [Leclercia adecarboxylata]
ATGCGCGCAAAACGTCTGACTGTCGCGATGAATGGCGATGTGATAGGCACGCTGCATCGTGATGGCAGCGGGGCGATGTC
CTTTCAGTATGCCCCAGCGTGGCTGGCAGAGCCGGGTTCGCGAGCGATCTCGCTCTCTCTGCCGCTGCAACACGGCAGGA
TTAGCGGCGCGCCGGTCTTCAATTTCTTCAGCAATCTGCTGCCTGACTCCGAGGCGATTATTGCCCGCATGCAGGCCCGT
TTTCAGGTGGAAACCACGCATCCTTTCGATCTGCTCGCTAGCGTTGGGCGTGACTGCGTCGGCGCCATTCAGCTCTATCC
GCCGGGGCAGGAGATCCCCCCGGTAACGGATATCGTGGCCGAACCGCTGGATGACGATCAGATTGCCGCGCTGCTCGAGG
GCTACCAGATGGCGCCGCTGGGGATGACAGAGGAGGGCGCCGATTTTCGCATTTCGCTGGCCGGGGCGCAGGAGAAAACG
GCGCTGCTGTGGTATCAGGATCGCTGGCAACGGCCCCAGGGCAGCACCCCAACCAGCCATATCTTCAAGCTGCCGATCGG
CAGAATAGAGCAGAATAACATCGACCTGAGCGAAAGCTGCGAAAACGAATGGCTCTGTTTGCGTATCGCCAAAGCCTTTG
GTTTCCCGGTGGCGCATGCCGACATGGCGCAGTTTGGCCGGAAAAAGGTGCTGATTATCGAGCGTTTTGATCGTCGATGG
GCCCGCAGCGGCTGGCTGATGCGCTTGCCGCAGGAGGACTTTTGCCAGGCGCTGGGCGTGTCGCCAGCGCTGAAATATGA
GTCTCACGGTGGCCCCGGGATTGCAGACGCCATGAAGCTGCTGCTTGGCTCTCGCCTGGCGGGGCAGGATCGCGAGATGT
TCTTTAAGGCGCAGATCCTTTTCTGGATGCTGGCCGCCATCGATGGCCACGGTAAAAATTTTAGCCTGTTTATTGAGGCC
GACTCCTCGTTTCGCATGGCCCCGCTGTATGACGTGATTTCCGCGTTTCCGCTGTTCGACGCCGGGGGGATCCCCATCAA
AAAGGCGAAGATGGCGATGGCGCTACAGGGAAAAAACCGGCAGTACCATTTCGCGATGATCCAGCCGCGTCACTTTATCA
GCACCGCCGCCTTTGCGGGATTTTCGCAGGAGGCTGCCCGCCGTTTGATGACGGAGATGGCCGCGGTTACCGACGACGTT
ATCGCCACCGTCAGGGCAGAACTGCCGACGGATTTTCCGCTGCCGGTGAGCGAGGCTATTTTTCGCGGTTTAGCCCGCCA
GGCGGCGCGGATAGGGCGATTCAATGAGTTAACCCCGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9166.46 Da        Isoelectric Point: 9.8953

>AT117684 WP_142489448.1 NZ_CP035382:c4071528-4071277 [Leclercia adecarboxylata]
MKVTSADALAQAVRDQRKVNKLTQTATAEQVGIKQTTVSDFENKPGSTKLDTLFKILAALDLELHVVKRGATLPDNNAWT
KEW

Download         Length: 252 bp

>AT117684 NZ_CP035382:c4071528-4071277 [Leclercia adecarboxylata]
ATGAAGGTGACATCGGCAGACGCACTGGCGCAGGCCGTCCGGGATCAGCGTAAGGTCAATAAGTTAACCCAAACGGCGAC
GGCTGAACAGGTAGGTATTAAACAAACCACCGTATCGGATTTCGAGAACAAACCGGGCTCCACCAAGCTGGACACCTTGT
TCAAAATCCTCGCGGCGCTGGACCTGGAACTGCACGTGGTAAAACGCGGCGCCACGCTGCCGGACAATAACGCCTGGACG
AAGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References