Detailed information of TA system TA117680

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PP_4151-4152/excise(antitoxin)
• Location: 2405273..2406309
• Replicon: chromosome
• Accession: NZ_CP035382
• Organism: Leclercia adecarboxylata strain R25

Toxin (Protein)

• Gene name: PP_4152
• Uniprot ID: -
• Locus tag: ES815_RS12435
• Protein ID: WP_142488063.1
• Coordinates: 2405273..2405848 (-)
• Length: 192 a.a.

Antitoxin (Protein)

• Gene name: PP_4151
• Uniprot ID: -
• Locus tag: ES815_RS12440
• Protein ID: WP_106995644.1
• Coordinates: 2405848..2406309 (-)
• Length: 154 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ES815_RS12430	2404385..2404984	-	600	WP_142488062.1	response regulator transcription factor	-
ES815_RS12435	2405273..2405848	-	576	WP_142488063.1	PIN domain-containing protein	Toxin
ES815_RS12440	2405848..2406309	-	462	WP_106995644.1	helix-turn-helix domain-containing protein	Antitoxin
ES815_RS12445	2406465..2406851	-	387	WP_142488064.1	VOC family protein	-
ES815_RS12450	2406853..2408010	-	1158	WP_142488065.1	MFS transporter	-
ES815_RS23755	2408007..2408165	-	159	WP_156262813.1	hypothetical protein	-
ES815_RS12455	2408264..2409034	+	771	WP_142488066.1	DeoR/GlpR family DNA-binding transcription regulator	-
ES815_RS12460	2409031..2409327	-	297	WP_142488067.1	SH3 domain-containing protein	-
ES815_RS12465	2409534..2410655	+	1122	WP_142488068.1	cupin domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (8-114)

Antitoxin

• Helix-turn-helix domain, group 17 (84-132)

Sequences

Toxin

Protein

• Length: 192 a.a.
• Molecular weight: 21747.96 Da
• Isoelectric Point: 4.8643

>T117680 WP_142488063.1 NZ_CP035382:c2405848-2405273 [Leclercia adecarboxylata]
MTHSPYPVVLDACVLYPSMLRDLLMHIGKTGLYQPKWTTQIHDEWQRNLLINRPDITADQLKRTEMLMNKAFGDACVSGY
ESIIDGLSLPDQDDRHVLAAAIRSDSEVIVTYNLVDFPGGNLAEFDVEALHPDEFLSDLFDLNHALVLEAVRMQRSHLRH
PPLNPDQFLQGLLQLGLPKTVTELEKYRVMI

Nucleotide

• Length: 576 bp

>T117680 NZ_CP035382:c2405848-2405273 [Leclercia adecarboxylata]
ATGACACACTCACCCTATCCCGTCGTTCTTGATGCCTGCGTGCTATACCCATCAATGCTGCGGGATCTTCTCATGCACAT
TGGGAAGACTGGCTTATATCAGCCCAAATGGACTACTCAGATACACGATGAATGGCAGCGTAATCTGCTTATTAATCGCC
CTGATATCACCGCAGACCAGCTGAAGCGCACCGAAATGCTCATGAATAAAGCCTTCGGCGACGCCTGCGTATCAGGGTAT
GAGAGTATTATTGATGGCCTTAGCCTGCCGGATCAGGATGACAGGCATGTACTCGCCGCGGCGATTCGTTCGGATTCCGA
AGTGATTGTAACCTACAATCTTGTCGATTTTCCCGGCGGAAACCTGGCTGAATTTGATGTTGAAGCGCTCCACCCGGATG
AGTTCTTATCAGACCTTTTTGACCTGAACCATGCGCTGGTTCTCGAGGCGGTGAGAATGCAGCGATCGCACCTGCGTCAT
CCTCCCCTCAACCCAGACCAATTTTTGCAAGGCCTGCTGCAACTGGGCTTGCCGAAAACAGTGACTGAGCTGGAAAAATA
CAGAGTAATGATTTAG

Antitoxin

Protein

• Length: 154 a.a.
• Molecular weight: 17085.59 Da
• Isoelectric Point: 6.3368

>AT117680 WP_106995644.1 NZ_CP035382:c2406309-2405848 [Leclercia adecarboxylata]
MTNSLLNSLTLPAPKEIEAAVRGQRELATFLSTKQETQKITIQDAQDVTHQIELPTSSLTLLMSILGELAAGNAVQVVPV
HAELTTQEAANILNVSRPHMVKLLEEGKLPFHKTGRHRRILFADLMKYKDQRDAESIQALRELAEQSQELGFY

Nucleotide

• Length: 462 bp

>AT117680 NZ_CP035382:c2406309-2405848 [Leclercia adecarboxylata]
ATGACAAACTCACTTCTGAACAGCCTTACGTTACCGGCTCCAAAGGAGATTGAGGCAGCTGTACGCGGACAAAGGGAGCT
TGCTACGTTCCTGTCCACAAAGCAGGAAACGCAGAAAATTACGATTCAGGATGCACAGGATGTGACCCATCAAATAGAGC
TTCCAACCTCTTCACTGACGCTTCTGATGAGTATCCTCGGTGAACTGGCTGCGGGCAATGCCGTCCAGGTTGTGCCCGTG
CATGCTGAATTAACGACGCAGGAAGCTGCCAACATCCTGAACGTTTCGCGCCCACATATGGTGAAACTTCTGGAGGAAGG
AAAGCTGCCTTTCCATAAAACTGGCCGTCATCGCCGCATTCTTTTTGCAGACTTGATGAAGTACAAAGATCAGCGTGATG
CAGAAAGCATACAAGCCCTTCGCGAGCTGGCGGAACAAAGTCAGGAGCTTGGATTTTACTGA