Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-MazE
Location 1926373..1927035 Replicon chromosome
Accession NZ_CP035382
Organism Leclercia adecarboxylata strain R25

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag ES815_RS10215 Protein ID WP_185902400.1
Coordinates 1926637..1927035 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag ES815_RS10210 Protein ID WP_142490039.1
Coordinates 1926373..1926633 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ES815_RS10175 1921381..1921695 - 315 WP_032615638.1 PTS sugar transporter subunit IIB -
ES815_RS10180 1921990..1922937 + 948 WP_142487693.1 LacI family transcriptional regulator -
ES815_RS10185 1922975..1923271 - 297 WP_032615642.1 hypothetical protein -
ES815_RS10190 1923301..1923564 + 264 WP_142487694.1 hypothetical protein -
ES815_RS10195 1923593..1924012 + 420 WP_142487695.1 GNAT family N-acetyltransferase -
ES815_RS10200 1924009..1924668 - 660 WP_142487696.1 TetR/AcrR family transcriptional regulator -
ES815_RS10205 1924747..1926255 + 1509 WP_142487697.1 MFS transporter -
ES815_RS10210 1926373..1926633 + 261 WP_142490039.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
ES815_RS10215 1926637..1927035 + 399 WP_185902400.1 type II toxin-antitoxin system VapC family toxin Toxin
ES815_RS10220 1927295..1927801 - 507 WP_142487698.1 hypothetical protein -
ES815_RS10225 1928143..1928946 + 804 WP_142487699.1 lipoprotein NlpA -
ES815_RS10230 1929085..1929864 + 780 WP_142487700.1 MBL fold metallo-hydrolase -
ES815_RS10235 1929891..1930844 + 954 WP_142487701.1 helix-turn-helix domain-containing protein -
ES815_RS10240 1930873..1931961 - 1089 WP_142487702.1 AAA family ATPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-121)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14729.89 Da        Isoelectric Point: 6.2149

>T117679 WP_185902400.1 NZ_CP035382:1926637-1927035 [Leclercia adecarboxylata]
MLHMLDTNIVSHLVKQHPSVVNRYSQIAPEEMCISSITEAELLYGVAKKQSHRLHETISEFLKTITVCDWDSDAAAIYGK
LRASMEKRGKVMGDLDQLIAAHALSRGTTIVTNDRAFAMVQELTIEDWTTAA

Download         Length: 399 bp

>T117679 NZ_CP035382:1926637-1927035 [Leclercia adecarboxylata]
ATGCTGCATATGCTGGACACTAACATAGTCAGCCACCTCGTGAAGCAACATCCCAGCGTGGTAAATCGCTATTCTCAAAT
AGCACCTGAAGAGATGTGCATTTCAAGCATAACGGAGGCTGAATTGCTTTATGGCGTCGCCAAAAAGCAAAGCCATAGAC
TGCATGAAACCATCTCGGAATTTCTTAAAACTATCACCGTTTGCGACTGGGACAGTGACGCCGCGGCAATCTACGGCAAA
CTACGCGCCTCAATGGAAAAGAGAGGGAAAGTGATGGGCGATCTCGATCAGTTGATCGCAGCGCACGCTCTCAGCCGGGG
CACAACCATTGTGACTAACGATCGTGCCTTTGCGATGGTGCAGGAACTGACTATCGAGGACTGGACCACCGCAGCCTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 10195.57 Da        Isoelectric Point: 9.8080

>AT117679 WP_142490039.1 NZ_CP035382:1926373-1926633 [Leclercia adecarboxylata]
MERKAKLFKKGRNQAVLLPAEFAFDSESVWIRRDEEGNVVLRAMSEKERHRENFLRLLKQTQVPDSFLSKEERNQSYTTR
DPLEGL

Download         Length: 261 bp

>AT117679 NZ_CP035382:1926373-1926633 [Leclercia adecarboxylata]
ATGGAACGTAAAGCAAAACTGTTCAAAAAAGGGCGAAACCAGGCGGTGTTACTGCCTGCGGAGTTCGCGTTTGATTCGGA
GAGCGTCTGGATCCGGCGGGATGAGGAGGGGAATGTTGTTTTGAGGGCTATGTCAGAGAAAGAACGGCACAGGGAGAATT
TTTTGCGTTTACTGAAGCAGACGCAGGTACCTGATTCATTCCTGAGTAAGGAGGAGCGCAATCAGAGTTATACGACAAGA
GATCCTCTTGAAGGGTTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References