Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09812-MazE
Location 135311..135901 Replicon chromosome
Accession NZ_CP035382
Organism Leclercia adecarboxylata strain R25

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag ES815_RS01750 Protein ID WP_142486330.1
Coordinates 135311..135643 (-) Length 111 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag ES815_RS01755 Protein ID WP_142486331.1
Coordinates 135644..135901 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ES815_RS01720 130380..131453 + 1074 WP_142486326.1 porin -
ES815_RS01725 131586..133199 + 1614 WP_142486327.1 sensor histidine kinase -
ES815_RS01730 133196..133921 + 726 WP_142486328.1 two-component system response regulator DcuR -
ES815_RS01740 134268..135065 + 798 WP_142486329.1 DgsA anti-repressor MtfA -
ES815_RS01750 135311..135643 - 333 WP_142486330.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
ES815_RS01755 135644..135901 - 258 WP_142486331.1 antitoxin Antitoxin
ES815_RS01760 136035..136985 - 951 WP_142486332.1 HTH-type transcriptional regulator Cbl -
ES815_RS01765 137082..137999 - 918 WP_142486333.1 nitrogen assimilation transcriptional regulator NAC -
ES815_RS01775 138495..140330 - 1836 WP_142486334.1 patatin-like phospholipase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-108)

Antitoxin

Antitoxin PemI-like

(5-84)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 11813.77 Da        Isoelectric Point: 10.4752

>T117674 WP_142486330.1 NZ_CP035382:c135643-135311 [Leclercia adecarboxylata]
MDRGEIWLVSLDPIAGHEQSGKRPVLIVSKAAFNHLTRLPVVVPVTTGGKFARTAGFAVSLDEAGSKTRGVIRCDQPRTI
DMGARHGIKLERVPDSVMNEVLAKLGALLT

Download         Length: 333 bp

>T117674 NZ_CP035382:c135643-135311 [Leclercia adecarboxylata]
ATGGATAGAGGGGAAATCTGGCTCGTTTCACTTGATCCTATTGCCGGGCATGAGCAAAGCGGAAAACGTCCGGTGCTTAT
CGTGTCGAAGGCTGCGTTCAATCATCTCACCCGCCTGCCTGTTGTGGTTCCTGTCACCACCGGCGGCAAGTTTGCCCGTA
CTGCGGGTTTTGCCGTATCCCTGGATGAAGCGGGCTCAAAAACCAGGGGCGTGATTCGCTGCGATCAGCCTCGTACCATA
GATATGGGAGCACGGCATGGCATAAAGTTGGAGCGTGTGCCGGATAGCGTAATGAATGAGGTACTTGCGAAGTTGGGTGC
TTTGTTAACCTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9285.71 Da        Isoelectric Point: 4.2950

>AT117674 WP_142486331.1 NZ_CP035382:c135901-135644 [Leclercia adecarboxylata]
MYITRLKKVGGSVMLAVPPAILKTLDLQPDSEVGVTIDNGCLIVEPQKRPHYSLAELLAQCDPQAELSEEDREWVDAPAA
GKELL

Download         Length: 258 bp

>AT117674 NZ_CP035382:c135901-135644 [Leclercia adecarboxylata]
ATGTACATAACACGTCTGAAAAAAGTGGGTGGCTCTGTCATGCTGGCAGTCCCTCCAGCGATTTTGAAAACGCTCGACCT
GCAACCAGACAGCGAGGTCGGCGTCACTATCGACAACGGCTGCCTGATAGTTGAACCGCAAAAACGCCCGCATTATTCAC
TTGCTGAACTGCTGGCGCAGTGCGATCCGCAGGCCGAACTCAGTGAAGAAGATCGAGAATGGGTTGATGCGCCAGCTGCA
GGCAAGGAGCTCCTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References