117660

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1226197..1226674 Replicon chromosome
Accession NZ_CP035369
Organism Staphylococcus aureus strain LAC

Toxin (Protein)


Gene name TsaT Uniprot ID Q2G005
Locus tag ERW10_RS06535 Protein ID WP_000052078.1
Coordinates 1226486..1226674 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag ERW10_RS06530 Protein ID WP_001059690.1
Coordinates 1226197..1226457 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ERW10_RS06495 1221590..1222306 - 717 WP_000150017.1 type I 3-dehydroquinate dehydratase -
ERW10_RS06500 1222454..1222876 + 423 WP_000974460.1 organic hydroperoxide resistance protein -
ERW10_RS06505 1223275..1223769 + 495 WP_000569884.1 GNAT family N-acetyltransferase -
ERW10_RS06510 1223924..1224541 + 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
ERW10_RS06515 1224614..1225195 - 582 WP_001140686.1 phosphoglycerate mutase family protein -
ERW10_RS06520 1225420..1225656 + 237 WP_000368687.1 hypothetical protein -
ERW10_RS06525 1225653..1225856 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
ERW10_RS06530 1226197..1226457 + 261 WP_001059690.1 hypothetical protein Antitoxin
ERW10_RS06535 1226486..1226674 + 189 WP_000052078.1 hypothetical protein Toxin
ERW10_RS06540 1226862..1227431 + 570 WP_001106654.1 hypothetical protein -
ERW10_RS06545 1227519..1227803 + 285 WP_001004395.1 hypothetical protein -
ERW10_RS06550 1227865..1228083 + 219 WP_000005886.1 hypothetical protein -
ERW10_RS06555 1228579..1228779 - 201 WP_001059082.1 cold-shock protein -
ERW10_RS06560 1229136..1229822 - 687 WP_001548082.1 thermonuclease family protein -
ERW10_RS06565 1230163..1230633 - 471 WP_000824472.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - selq / selk / vWbp 1200908..1240346 39438


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7172.84 Da        Isoelectric Point: 9.9971

>T117660 WP_000052078.1 NZ_CP035369:1226486-1226674 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTSKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T117660 NZ_CP035369:1226486-1226674 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTAGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT117660 WP_001059690.1 NZ_CP035369:1226197-1226457 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT117660 NZ_CP035369:1226197-1226457 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D6HZ40

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References