Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 728604..729248 Replicon chromosome
Accession NZ_CP035368
Organism Haemophilus parainfluenzae strain LC_1315_18

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag ERO09_RS03520 Protein ID WP_128787152.1
Coordinates 729063..729248 (-) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag ERO09_RS03515 Protein ID WP_005643263.1
Coordinates 728604..729032 (-) Length 143 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ERO09_RS03495 726374..726979 - 606 WP_128787149.1 DedA family protein -
ERO09_RS03500 727206..727493 + 288 WP_014065570.1 50S ribosomal protein L25 -
ERO09_RS03505 727642..727998 - 357 WP_128787150.1 tyrosine-type recombinase/integrase -
ERO09_RS03510 728151..728603 + 453 WP_149785862.1 DUF1367 family protein -
ERO09_RS03515 728604..729032 - 429 WP_005643263.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
ERO09_RS03520 729063..729248 - 186 WP_128787152.1 type II toxin-antitoxin system HicA family toxin Toxin
ERO09_RS03525 729675..730421 + 747 WP_128787153.1 hypothetical protein -
ERO09_RS03530 730538..730953 - 416 Protein_680 IS200/IS605 family transposase -
ERO09_RS03535 731000..732136 + 1137 WP_128787154.1 transposase -
ERO09_RS03540 732532..733326 + 795 WP_128787155.1 tRNA pseudouridine(38-40) synthase TruA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-60)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-134)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 6757.93 Da        Isoelectric Point: 11.1595

>T117653 WP_128787152.1 NZ_CP035368:c729248-729063 [Haemophilus parainfluenzae]
MRSSDLIKELKNAGCTFVRHGKGDHQIWQSPITGKTFPIPHPKQHVPIGTLRSIKKSAGLL

Download         Length: 186 bp

>T117653 NZ_CP035368:c729248-729063 [Haemophilus parainfluenzae]
ATGCGATCCAGCGACTTAATCAAGGAACTTAAAAATGCAGGTTGTACTTTTGTCAGGCACGGTAAAGGCGATCATCAAAT
TTGGCAATCGCCCATCACAGGGAAGACGTTCCCCATACCGCATCCCAAACAACACGTACCCATCGGCACATTAAGATCCA
TCAAAAAATCGGCAGGGCTTCTATAG

Antitoxin


Download         Length: 143 a.a.        Molecular weight: 16400.42 Da        Isoelectric Point: 4.3779

>AT117653 WP_005643263.1 NZ_CP035368:c729032-728604 [Haemophilus parainfluenzae]
MLFTIGIETPTNENEAYGITVPALFTEEYSCFSAADTLEEIPTQVTDAIHSILEMMFEDGIDINALQDKGYRHYQTQEDF
NYCDTWLLLDVDISAYQGKRHRINISLPEYLIKRIDSRVASNPIYKDRSHFLAIASQKELRQ

Download         Length: 429 bp

>AT117653 NZ_CP035368:c729032-728604 [Haemophilus parainfluenzae]
ATGTTATTTACCATCGGCATTGAAACCCCAACAAATGAAAATGAAGCCTATGGCATCACTGTGCCAGCATTATTTACTGA
AGAATATTCCTGCTTTAGTGCCGCTGATACCCTTGAAGAAATCCCGACGCAGGTGACTGATGCTATTCACTCCATCTTAG
AAATGATGTTTGAAGACGGAATAGACATCAATGCGCTTCAAGACAAAGGCTATCGTCACTACCAAACGCAAGAAGATTTC
AACTATTGCGATACTTGGTTGTTGCTTGATGTAGATATTTCAGCATATCAAGGCAAACGCCACCGTATTAATATCAGCTT
GCCTGAATACCTTATCAAACGTATTGATAGCCGTGTTGCAAGCAATCCAATTTACAAAGACCGCAGCCACTTTTTAGCGA
TTGCCTCACAAAAAGAGCTACGGCAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References