Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 342697..344255 Replicon chromosome
Accession NZ_CP035368
Organism Haemophilus parainfluenzae strain LC_1315_18

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag ERO09_RS01605 Protein ID WP_080969737.1
Coordinates 342975..344255 (+) Length 427 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag ERO09_RS01600 Protein ID WP_049355840.1
Coordinates 342697..342975 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ERO09_RS01575 337822..338349 + 528 WP_065244522.1 ribosome maturation factor RimM -
ERO09_RS01580 338387..339127 + 741 WP_128786909.1 tRNA (guanosine(37)-N1)-methyltransferase TrmD -
ERO09_RS01585 339164..339514 + 351 WP_128786919.1 50S ribosomal protein L19 -
ERO09_RS01590 339575..340837 - 1263 WP_005695393.1 transcription termination factor Rho -
ERO09_RS01595 341068..342441 + 1374 WP_049355842.1 argininosuccinate lyase -
ERO09_RS01600 342697..342975 + 279 WP_049355840.1 helix-turn-helix domain-containing protein Antitoxin
ERO09_RS01605 342975..344255 + 1281 WP_080969737.1 type II toxin-antitoxin system HipA family toxin Toxin
ERO09_RS01610 344294..344705 - 412 Protein_309 hypothetical protein -
ERO09_RS01615 344776..345267 - 492 WP_049355836.1 YajQ family cyclic di-GMP-binding protein -
ERO09_RS01620 345288..346232 - 945 WP_128786920.1 phosphoserine phosphatase -
ERO09_RS01625 346301..346978 + 678 WP_075875828.1 YtjB family periplasmic protein -
ERO09_RS01630 347064..349061 + 1998 WP_128786921.1 transketolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - galE 300996..459473 158477


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(148-391)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-64)


Sequences

Toxin        


Download         Length: 427 a.a.        Molecular weight: 49124.49 Da        Isoelectric Point: 8.7442

>T117652 WP_080969737.1 NZ_CP035368:342975-344255 [Haemophilus parainfluenzae]
MSNTILNVAMNGLLVGEWRKLTSGATEFQYAKKWLESVRSRPISLSLPLSYKTYRGDSVYNFFDNLLPDNEQIRSRIQQR
FQTSTKSPFDLLSAIGQDCIGAIQLYQGENRSVRQIYAEPLNDKEVENVLKNYRTFPLGMEESEDFRISLAGAQEKTALL
YYQNQWQRPLHSTATSHIFKLPIGMVAQGQLDLSGSCENEWLCLNIMKAFGLPVPRSQIQYFGEMKVLIVERFDRRWSEN
RSWLIRLPQEDMCQALNIAPARKYENDGGPSILQIMSLLNGSSNAQADRKQFFKAQIIFWLLCAIDGHGKNFSLFLEQEN
RYRLTPFYDVISAYPLIKHNGLQKQKVKMAMAWQGENKHYLWDKIQLRHIFNTAKLAGLAKEVVEEILHEISVRYPKVSE
INTHGLPEEIVEPILMGLESKMKKIS

Download         Length: 1281 bp

>T117652 NZ_CP035368:342975-344255 [Haemophilus parainfluenzae]
ATGAGCAATACTATTCTAAATGTTGCCATGAATGGCTTATTGGTAGGCGAATGGCGAAAACTCACTAGCGGTGCAACTGA
ATTTCAGTATGCTAAAAAATGGCTTGAATCTGTGCGTTCACGCCCTATTTCATTGTCATTGCCCTTATCTTACAAAACTT
ATCGAGGCGATTCTGTTTATAATTTCTTCGATAATCTTCTCCCTGACAACGAGCAGATCCGTTCACGCATTCAACAACGT
TTCCAAACCTCAACGAAATCCCCATTTGATTTACTTTCGGCGATTGGACAGGATTGTATCGGCGCAATTCAACTTTATCA
GGGCGAGAACCGCTCGGTACGTCAAATTTATGCAGAACCACTCAATGACAAAGAGGTGGAAAACGTGCTGAAAAACTACC
GCACTTTTCCTCTCGGCATGGAAGAAAGCGAGGATTTCCGAATTTCTTTAGCCGGCGCTCAGGAAAAAACAGCGCTTCTT
TATTATCAGAATCAATGGCAGCGCCCTTTACATTCCACCGCGACCAGTCATATTTTTAAGCTCCCGATTGGTATGGTTGC
ACAAGGGCAACTTGATCTTTCCGGCAGCTGTGAAAATGAATGGCTTTGCTTGAATATTATGAAAGCCTTCGGTTTGCCTG
TTCCTCGAAGTCAAATTCAGTATTTCGGTGAAATGAAAGTGTTGATTGTGGAGCGCTTTGATCGCCGTTGGTCTGAAAAT
AGGAGTTGGCTAATTCGTTTACCACAGGAAGATATGTGCCAAGCACTCAACATCGCCCCTGCGAGGAAATATGAAAATGA
CGGTGGGCCAAGCATTCTTCAAATTATGTCGCTCCTCAATGGCTCATCTAATGCTCAAGCAGATCGCAAGCAATTTTTTA
AAGCGCAAATTATTTTCTGGCTGCTTTGCGCTATTGACGGACATGGCAAAAATTTCAGTCTATTTTTAGAACAAGAGAAT
CGCTATCGTCTAACGCCTTTTTATGATGTGATCTCTGCCTATCCGCTAATCAAACACAATGGACTACAAAAGCAAAAAGT
CAAAATGGCAATGGCGTGGCAGGGCGAAAATAAACACTATTTATGGGATAAAATACAACTCCGACATATTTTCAACACCG
CTAAACTCGCAGGCTTGGCAAAGGAAGTGGTAGAGGAAATTTTGCATGAGATCAGTGTTCGATATCCAAAAGTAAGTGAA
ATAAATACCCATGGATTACCTGAAGAAATTGTTGAGCCAATTTTAATGGGATTGGAATCCAAGATGAAAAAGATAAGTTA
G

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10584.10 Da        Isoelectric Point: 5.8769

>AT117652 WP_049355840.1 NZ_CP035368:342697-342975 [Haemophilus parainfluenzae]
MVITTAKMLSHVIREFRYQRDLSQTDVAKLAGTTQARISAFENEPERTKLETLFKILAGLELELVVQPRKKSSDIIRSIK
EPTTTYDDDEAW

Download         Length: 279 bp

>AT117652 NZ_CP035368:342697-342975 [Haemophilus parainfluenzae]
ATGGTTATTACCACCGCAAAAATGCTTTCTCATGTAATTCGGGAATTTCGTTATCAAAGAGACCTGTCACAAACTGATGT
AGCAAAACTTGCTGGGACTACCCAAGCTAGAATTTCAGCGTTTGAAAATGAACCAGAGCGTACAAAATTAGAAACGTTAT
TTAAAATTCTGGCAGGATTAGAACTAGAACTTGTTGTGCAACCACGCAAAAAGTCATCTGATATCATCCGTTCAATCAAA
GAACCAACTACAACATACGATGATGATGAGGCGTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References