Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 1193097..1193575 Replicon chromosome
Accession NZ_CP035366
Organism Escherichia coli O157:H7 strain C1-057

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A891SFN9
Locus tag ES669_RS05705 Protein ID WP_001303876.1
Coordinates 1193097..1193384 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XD67
Locus tag ES669_RS05710 Protein ID WP_000536233.1
Coordinates 1193384..1193575 (-) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ES669_RS05665 1188246..1190717 - 2472 WP_000034474.1 exonuclease -
ES669_RS05670 1190811..1191002 - 192 WP_001098307.1 DUF1482 family protein -
ES669_RS05675 1190999..1191187 - 189 WP_000413705.1 cell division inhibition protein DicB -
ES669_RS05685 1191761..1191946 + 186 WP_001133046.1 hypothetical protein -
ES669_RS05690 1192133..1192522 - 390 WP_000394511.1 hypothetical protein -
ES669_RS05695 1192664..1192819 - 156 WP_000379575.1 DUF1391 family protein -
ES669_RS05705 1193097..1193384 - 288 WP_001303876.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ES669_RS05710 1193384..1193575 - 192 WP_000536233.1 hypothetical protein Antitoxin
ES669_RS05715 1193603..1194004 - 402 WP_000986592.1 helix-turn-helix domain-containing protein -
ES669_RS05720 1194113..1194385 + 273 WP_000887453.1 helix-turn-helix domain-containing protein -
ES669_RS05725 1194369..1194794 + 426 WP_000693855.1 Rha family transcriptional regulator -
ES669_RS05730 1195001..1195456 - 456 WP_000273724.1 hypothetical protein -
ES669_RS05735 1195535..1196626 + 1092 WP_001205823.1 hypothetical protein -
ES669_RS05740 1196633..1197379 + 747 WP_000788751.1 ATP-binding protein -
ES669_RS05745 1197401..1198171 + 771 WP_000450992.1 DUF1627 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10978.84 Da        Isoelectric Point: 10.1360

>T117618 WP_001303876.1 NZ_CP035366:c1193384-1193097 [Escherichia coli O157:H7]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Download         Length: 288 bp

>T117618 NZ_CP035366:c1193384-1193097 [Escherichia coli O157:H7]
ATGTTACCCATTTTATGGCTACCGTCTGCTCGCGATGATTTGCGCCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCACGTAGACTAAAAATACGCATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACTTATATCCACCAAGCG
AACGGGTTTCTGGATTGAGAGAGATCGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATTCTCGGCGACAATTTCCCTTCTCTATCTGA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7025.80 Da        Isoelectric Point: 4.0270

>AT117618 WP_000536233.1 NZ_CP035366:c1193575-1193384 [Escherichia coli O157:H7]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Download         Length: 192 bp

>AT117618 NZ_CP035366:c1193575-1193384 [Escherichia coli O157:H7]
ATGGGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCAC
TAAAGTAACGTCAAGCCTTGCAGACACTCGCCCCGCAATTCCACATGACGAGGTAATGGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAAGAGCGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References