Detailed information of TA system TA117611

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pezAT/zeta-ParD
• Location: 142605..143557
• Replicon: chromosome
• Accession: NZ_CP035319
• Organism: Rhodococcus sp. ABRD24

Toxin (Protein)

• Gene name: pezT
• Uniprot ID: -
• Locus tag: ERC79_RS00560
• Protein ID: WP_131574831.1
• Coordinates: 142979..143557 (+)
• Length: 193 a.a.

Antitoxin (Protein)

• Gene name: pezA
• Uniprot ID: -
• Locus tag: ERC79_RS00555
• Protein ID: WP_131574830.1
• Coordinates: 142605..142982 (+)
• Length: 126 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ERC79_RS00530	137724..138338	+	615	WP_131574823.1	CBS domain-containing protein	-
ERC79_RS00535	138335..139213	+	879	WP_131574824.1	universal stress protein	-
ERC79_RS00540	139251..139679	-	429	WP_131574826.1	Hsp20/alpha crystallin family protein	-
ERC79_RS00545	139769..140659	-	891	WP_131580617.1	universal stress protein	-
ERC79_RS00550	140714..142432	-	1719	WP_165497016.1	GAF domain-containing protein	-
ERC79_RS00555	142605..142982	+	378	WP_131574830.1	hypothetical protein	Antitoxin
ERC79_RS00560	142979..143557	+	579	WP_131574831.1	zeta toxin family protein	Toxin
ERC79_RS00565	144664..145242	-	579	WP_131574833.1	TetR family transcriptional regulator C-terminal domain-containing protein	-
ERC79_RS00570	145335..146183	+	849	WP_131574835.1	class I SAM-dependent methyltransferase	-
ERC79_RS00575	146405..147178	+	774	WP_131574837.1	SigB/SigF/SigG family RNA polymerase sigma factor	-
ERC79_RS00580	147268..147501	-	234	WP_131574838.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (5-138)

Antitoxin

• ParD-like antitoxin of type II bacterial toxin-antitoxin system (7-62)

Sequences

Toxin

Protein

• Length: 193 a.a.
• Molecular weight: 21160.25 Da
• Isoelectric Point: 5.6169

>T117611 WP_131574831.1 NZ_CP035319:142979-143557 [Rhodococcus sp. ABRD24]
VRRLDLIVGPNGAGKSTFVEQRLAPLLPGSIFVNADVIAKDRWPDSAEEHSYEAAQIAATIRLALIKQGESFIAETVFSH
PSKLELIDRAREAGYVVVLHIVLVPVELSVARVAERVVEGGHSVPEEKIRERFKRLWPLVVDAIGRADHATVYDNTAADV
TRIVARFVDGDAVAEIIWPAWTPEDLTKMVHG

Nucleotide

• Length: 579 bp

>T117611 NZ_CP035319:142979-143557 [Rhodococcus sp. ABRD24]
GTGAGACGTCTCGACCTGATCGTCGGACCGAATGGCGCCGGTAAGTCGACGTTCGTCGAGCAACGCCTCGCGCCGCTGCT
GCCGGGCAGCATATTCGTCAACGCCGACGTCATCGCCAAGGACCGCTGGCCTGACAGTGCCGAGGAGCACTCCTACGAGG
CCGCGCAGATTGCAGCGACGATCCGACTCGCCCTGATCAAGCAGGGGGAGTCGTTCATCGCCGAGACGGTGTTCTCGCAC
CCCTCGAAACTGGAGTTGATCGACCGGGCCCGCGAGGCCGGGTACGTCGTCGTGCTCCACATAGTCCTGGTGCCAGTCGA
GCTGTCGGTCGCTCGTGTTGCCGAACGCGTCGTCGAGGGCGGGCACTCGGTGCCCGAGGAAAAGATTCGCGAGCGATTCA
AGCGACTGTGGCCGCTGGTCGTAGACGCGATCGGCCGAGCCGACCACGCGACCGTCTACGACAACACCGCCGCGGACGTC
ACACGGATCGTCGCGCGGTTCGTCGACGGAGACGCGGTAGCCGAGATCATCTGGCCTGCATGGACTCCAGAAGATCTGAC
CAAAATGGTCCATGGCTGA

Antitoxin

Protein

• Length: 126 a.a.
• Molecular weight: 13539.10 Da
• Isoelectric Point: 6.4912

>AT117611 WP_131574830.1 NZ_CP035319:142605-142982 [Rhodococcus sp. ABRD24]
MTEVADKVTRFSAELFDAASAEGEREHRSARQQLEHWARVGREVSNQRRVARRRVEAALAGRISLSALSAEEGAVFNAEI
AATLEESLAAGNHVADRAAQGRAAVVLDDQGRVVKHLPDGTQIIL

Nucleotide

• Length: 378 bp

>AT117611 NZ_CP035319:142605-142982 [Rhodococcus sp. ABRD24]
ATGACGGAGGTCGCCGACAAGGTCACCAGGTTCTCGGCGGAGCTCTTCGACGCCGCTTCGGCCGAGGGGGAGCGCGAGCA
CCGCTCGGCACGCCAGCAGCTCGAGCACTGGGCCCGGGTCGGTCGCGAGGTGTCGAATCAGCGACGGGTCGCTCGCCGTC
GCGTCGAGGCGGCCCTCGCCGGCCGGATATCGCTGAGCGCGCTCTCCGCCGAGGAAGGCGCGGTGTTCAACGCCGAGATC
GCGGCCACACTCGAAGAATCACTCGCCGCAGGCAACCATGTCGCCGACCGCGCCGCCCAGGGCCGCGCGGCGGTCGTGCT
CGACGACCAGGGACGCGTCGTCAAACACCTTCCTGACGGCACCCAAATCATCCTGTGA