Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 7478..8003 Replicon plasmid pST1539
Accession NZ_CP035302
Organism Salmonella enterica subsp. enterica strain ST1539

Toxin (Protein)


Gene name ccdB Uniprot ID I3W3D5
Locus tag ST1539_RS24205 Protein ID WP_001159863.1
Coordinates 7478..7783 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID M7S5D0
Locus tag ST1539_RS24210 Protein ID WP_000813641.1
Coordinates 7785..8003 (-) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ST1539_RS24165 2857..3417 - 561 WP_000900095.1 inverse autotransporter beta domain-containing protein -
ST1539_RS24790 3573..3860 + 288 WP_071530243.1 hypothetical protein -
ST1539_RS24170 4137..4622 - 486 WP_000905606.1 membrane protein -
ST1539_RS24175 4616..5125 - 510 WP_001541544.1 CaiF/GrlA family transcriptional regulator -
ST1539_RS24185 5129..5842 - 714 Protein_8 EAL domain-containing protein -
ST1539_RS24190 5851..6633 - 783 WP_000082169.1 site-specific integrase -
ST1539_RS24195 6668..7189 - 522 WP_000198608.1 hypothetical protein -
ST1539_RS24200 7186..7476 - 291 WP_001266176.1 hypothetical protein -
ST1539_RS24205 7478..7783 - 306 WP_001159863.1 type II toxin-antitoxin system toxin CcdB Toxin
ST1539_RS24210 7785..8003 - 219 WP_000813641.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
ST1539_RS24215 8679..9200 + 522 WP_010999942.1 hypothetical protein -
ST1539_RS24225 9684..9980 + 297 WP_001687482.1 hypothetical protein -
ST1539_RS24230 10474..11463 + 990 WP_001527061.1 RepB family plasmid replication initiator protein -
ST1539_RS24235 11722..12166 - 445 Protein_17 site-specific integrase -
ST1539_RS24240 12335..12716 - 382 Protein_18 YgiW/YdeI family stress tolerance OB fold protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..93876 93876


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 15030.03 Da        Isoelectric Point: 5.5500

>T117575 WP_001159863.1 NZ_CP035302:c7783-7478 [Salmonella enterica subsp. enterica]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFF

Download         Length: 306 bp

>T117575 NZ_CP035302:c7783-7478 [Salmonella enterica subsp. enterica]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 10761.91 Da        Isoelectric Point: 5.5500

>AT117575 WP_000813641.1 NZ_CP035302:c8003-7785 [Salmonella enterica subsp. enterica]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Download         Length: 219 bp

>AT117575 NZ_CP035302:c8003-7785 [Salmonella enterica subsp. enterica]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB I3W3D5

Antitoxin

Source ID Structure
AlphaFold DB A0A656ICA6

References