Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | ccdAB/CcdA(antitoxin) |
Location | 7478..8003 | Replicon | plasmid pST1539 |
Accession | NZ_CP035302 | ||
Organism | Salmonella enterica subsp. enterica strain ST1539 |
Toxin (Protein)
Gene name | ccdB | Uniprot ID | I3W3D5 |
Locus tag | ST1539_RS24205 | Protein ID | WP_001159863.1 |
Coordinates | 7478..7783 (-) | Length | 102 a.a. |
Antitoxin (Protein)
Gene name | ccdA | Uniprot ID | M7S5D0 |
Locus tag | ST1539_RS24210 | Protein ID | WP_000813641.1 |
Coordinates | 7785..8003 (-) | Length | 73 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
ST1539_RS24165 | 2857..3417 | - | 561 | WP_000900095.1 | inverse autotransporter beta domain-containing protein | - |
ST1539_RS24790 | 3573..3860 | + | 288 | WP_071530243.1 | hypothetical protein | - |
ST1539_RS24170 | 4137..4622 | - | 486 | WP_000905606.1 | membrane protein | - |
ST1539_RS24175 | 4616..5125 | - | 510 | WP_001541544.1 | CaiF/GrlA family transcriptional regulator | - |
ST1539_RS24185 | 5129..5842 | - | 714 | Protein_8 | EAL domain-containing protein | - |
ST1539_RS24190 | 5851..6633 | - | 783 | WP_000082169.1 | site-specific integrase | - |
ST1539_RS24195 | 6668..7189 | - | 522 | WP_000198608.1 | hypothetical protein | - |
ST1539_RS24200 | 7186..7476 | - | 291 | WP_001266176.1 | hypothetical protein | - |
ST1539_RS24205 | 7478..7783 | - | 306 | WP_001159863.1 | type II toxin-antitoxin system toxin CcdB | Toxin |
ST1539_RS24210 | 7785..8003 | - | 219 | WP_000813641.1 | type II toxin-antitoxin system antitoxin CcdA | Antitoxin |
ST1539_RS24215 | 8679..9200 | + | 522 | WP_010999942.1 | hypothetical protein | - |
ST1539_RS24225 | 9684..9980 | + | 297 | WP_001687482.1 | hypothetical protein | - |
ST1539_RS24230 | 10474..11463 | + | 990 | WP_001527061.1 | RepB family plasmid replication initiator protein | - |
ST1539_RS24235 | 11722..12166 | - | 445 | Protein_17 | site-specific integrase | - |
ST1539_RS24240 | 12335..12716 | - | 382 | Protein_18 | YgiW/YdeI family stress tolerance OB fold protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Non-Mobilizable plasmid | - | - | 1..93876 | 93876 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 102 a.a. Molecular weight: 15030.03 Da Isoelectric Point: 5.5500
>T117575 WP_001159863.1 NZ_CP035302:c7783-7478 [Salmonella enterica subsp. enterica]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
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FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFF
Download Length: 306 bp
>T117575 NZ_CP035302:c7783-7478 [Salmonella enterica subsp. enterica]
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Antitoxin
Download Length: 73 a.a. Molecular weight: 10761.91 Da Isoelectric Point: 5.5500
>AT117575 WP_000813641.1 NZ_CP035302:c8003-7785 [Salmonella enterica subsp. enterica]
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Download Length: 219 bp
>AT117575 NZ_CP035302:c8003-7785 [Salmonella enterica subsp. enterica]
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Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | I3W3D5 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A656ICA6 |