Detailed information of TA system TA117573

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 2799860..2800461
• Replicon: chromosome
• Accession: NZ_CP035300
• Organism: Dyella sp. M7H15-1

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: EO087_RS12965
• Protein ID: WP_128899947.1
• Coordinates: 2800279..2800461 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: EO087_RS12960
• Protein ID: WP_128899228.1
• Coordinates: 2799860..2800270 (-)
• Length: 137 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EO087_RS12945	2796819..2797451	+	633	WP_128899226.1	isopentenyl-diphosphate Delta-isomerase	-
EO087_RS12950	2797587..2798729	+	1143	WP_128899227.1	adenosyl-hopene transferase HpnH	-
EO087_RS12955	2798748..2799851	+	1104	WP_128899946.1	glycosyltransferase	-
EO087_RS12960	2799860..2800270	-	411	WP_128899228.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
EO087_RS12965	2800279..2800461	-	183	WP_128899947.1	type II toxin-antitoxin system HicA family toxin	Toxin
EO087_RS12970	2800693..2801349	-	657	WP_205744365.1	fimbria/pilus periplasmic chaperone	-
EO087_RS12975	2801521..2802177	-	657	WP_205744366.1	fimbria/pilus periplasmic chaperone	-
EO087_RS12980	2802862..2803335	-	474	WP_164931839.1	type 1 fimbrial protein	-
EO087_RS12985	2803427..2803957	-	531	WP_128899232.1	type 1 fimbrial protein	-
EO087_RS12990	2804070..2804600	-	531	WP_128899233.1	fimbrial protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-127)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6650.76 Da
• Isoelectric Point: 11.0850

>T117573 WP_128899947.1 NZ_CP035300:c2800461-2800279 [Dyella sp. M7H15-1]
IKSADVIKRLEAEGWMLSRIKGSHHQFKHPAKPGLVTVPHPKADTPKGTFHSIAKQAGWK

Nucleotide

• Length: 183 bp

>T117573 NZ_CP035300:c2800461-2800279 [Dyella sp. M7H15-1]
ATAAAGAGCGCGGATGTGATCAAGCGGCTGGAAGCCGAGGGCTGGATGCTTAGCCGAATCAAGGGTTCACATCACCAGTT
CAAACATCCAGCAAAGCCCGGCCTTGTAACTGTCCCGCACCCCAAAGCCGATACTCCGAAAGGTACTTTCCATAGCATCG
CCAAGCAGGCGGGATGGAAATAG

Antitoxin

Protein

• Length: 137 a.a.
• Molecular weight: 14919.91 Da
• Isoelectric Point: 4.6143

>AT117573 WP_128899228.1 NZ_CP035300:c2800270-2799860 [Dyella sp. M7H15-1]
MRFPVVLHTDDGLHYGVIVPDLPGCYSAGDSIDDALVQVLEAIDLHLEGMMEDDKTELPEPSLINAHQQNPDYVGGIWAV
VDFDTSKYEGKAEKINITVPRKLLSKIDAYVSNHPGETRSGFMTRAALQVIRGKAA

Nucleotide

• Length: 411 bp

>AT117573 NZ_CP035300:c2800270-2799860 [Dyella sp. M7H15-1]
ATGCGATTCCCAGTTGTTCTCCATACGGATGACGGCCTGCACTACGGCGTCATCGTCCCGGATTTGCCTGGCTGTTATTC
GGCAGGCGATTCTATTGATGACGCCCTCGTGCAAGTACTTGAGGCCATCGACCTGCATCTGGAGGGCATGATGGAAGACG
ACAAGACCGAGCTACCGGAACCCAGCCTGATCAATGCGCACCAGCAGAATCCGGATTACGTCGGTGGCATATGGGCCGTG
GTCGACTTCGATACGTCCAAGTACGAAGGCAAGGCGGAAAAAATCAACATTACCGTGCCACGTAAGTTGCTTTCGAAGAT
CGATGCCTATGTGTCCAATCATCCAGGAGAGACACGATCTGGCTTTATGACTCGTGCCGCCCTGCAAGTGATACGCGGCA
AAGCTGCGTAA