Detailed information of TA system TA117571

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tad-ata/COG5606-COG4679
• Location: 2476436..2477118
• Replicon: chromosome
• Accession: NZ_CP035300
• Organism: Dyella sp. M7H15-1

Toxin (Protein)

• Gene name: tad
• Uniprot ID: -
• Locus tag: EO087_RS11475
• Protein ID: WP_128899921.1
• Coordinates: 2476798..2477118 (-)
• Length: 107 a.a.

Antitoxin (Protein)

• Gene name: ata
• Uniprot ID: -
• Locus tag: EO087_RS11470
• Protein ID: WP_128898980.1
• Coordinates: 2476436..2476759 (-)
• Length: 108 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EO087_RS11455	2471960..2473495	+	1536	WP_128898977.1	FAD-dependent monooxygenase	-
EO087_RS11460	2473519..2475351	+	1833	WP_205744487.1	KUP/HAK/KT family potassium transporter	-
EO087_RS16270	2475358..2475531	-	174	WP_164931826.1	hypothetical protein	-
EO087_RS11465	2475696..2476382	+	687	WP_128898979.1	aspartyl/asparaginyl beta-hydroxylase domain-containing protein	-
EO087_RS11470	2476436..2476759	-	324	WP_128898980.1	helix-turn-helix domain-containing protein	Antitoxin
EO087_RS11475	2476798..2477118	-	321	WP_128899921.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
EO087_RS11480	2477254..2477514	+	261	WP_128898981.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	-
EO087_RS11485	2477575..2477874	+	300	WP_205744488.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	-
EO087_RS11490	2477883..2478275	+	393	WP_205744489.1	PIN domain-containing protein	-
EO087_RS11495	2478326..2478601	-	276	WP_128898984.1	hypothetical protein	-
EO087_RS11500	2478718..2480073	-	1356	WP_128898985.1	hypothetical protein	-
EO087_RS11505	2480462..2481841	-	1380	WP_128898986.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (16-105)

Antitoxin

• Cro/C1-type helix-turn-helix domain (30-85)

Sequences

Toxin

Protein

• Length: 107 a.a.
• Molecular weight: 11761.65 Da
• Isoelectric Point: 8.0368

>T117571 WP_128899921.1 NZ_CP035300:c2477118-2476798 [Dyella sp. M7H15-1]
MDPQMKKLFWIGSAKKDLVAMPEEVQDTFGYALHLAQVGKKYEQTKPLKGFGSASVLEVVEDSGGGTFRAVYTVKLVDAV
YVLHCFQKKSTHGIATPKPDMDLIRE

Nucleotide

• Length: 321 bp

>T117571 NZ_CP035300:c2477118-2476798 [Dyella sp. M7H15-1]
ATGGATCCACAAATGAAGAAGTTGTTCTGGATCGGGTCAGCCAAGAAAGACTTGGTGGCGATGCCGGAAGAGGTGCAAGA
CACTTTCGGCTATGCGCTGCATCTGGCGCAGGTTGGCAAGAAGTACGAACAGACGAAACCATTGAAGGGGTTCGGCTCGG
CAAGTGTCCTTGAGGTGGTTGAAGACTCCGGCGGCGGTACGTTCCGCGCCGTCTACACCGTCAAGTTGGTCGACGCGGTT
TATGTCCTGCATTGCTTTCAGAAGAAATCGACGCATGGCATAGCCACGCCGAAGCCGGACATGGATTTGATTCGGGAATG
A

Antitoxin

Protein

• Length: 108 a.a.
• Molecular weight: 11569.59 Da
• Isoelectric Point: 10.4014

>AT117571 WP_128898980.1 NZ_CP035300:c2476759-2476436 [Dyella sp. M7H15-1]
MTKIEESTGNVYADLGMVDAEEMLVKAQLASKIGEIIKGRKWSQQQAADVLGIPQPKLSKMLRGQFRGISETKMLDCLAR
LGRDVQIVVGPARRAASAGRVAVVFAV

Nucleotide

• Length: 324 bp

>AT117571 NZ_CP035300:c2476759-2476436 [Dyella sp. M7H15-1]
ATGACCAAGATCGAAGAAAGCACGGGCAACGTCTATGCCGATCTGGGCATGGTTGATGCCGAAGAAATGCTTGTGAAGGC
CCAACTTGCCAGCAAGATTGGCGAGATCATCAAGGGCCGGAAGTGGAGTCAGCAGCAAGCCGCTGATGTTCTCGGCATCC
CTCAGCCGAAGCTATCCAAGATGCTGCGCGGCCAGTTTCGCGGCATCAGTGAAACGAAGATGCTTGATTGCCTCGCGCGG
CTAGGCCGTGACGTGCAAATCGTTGTCGGCCCGGCTCGACGTGCGGCTTCTGCCGGGCGCGTTGCCGTTGTCTTCGCGGT
CTAA