Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parE_1-relB/RelE(toxin)
Location 790364..790833 Replicon chromosome
Accession NZ_CP035300
Organism Dyella sp. M7H15-1

Toxin (Protein)


Gene name parE_1 Uniprot ID -
Locus tag EO087_RS03875 Protein ID WP_205744469.1
Coordinates 790364..790642 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag EO087_RS03880 Protein ID WP_128897725.1
Coordinates 790639..790833 (-) Length 65 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EO087_RS03855 786201..786823 + 623 Protein_755 site-specific integrase -
EO087_RS03860 787128..788696 + 1569 WP_128897722.1 IS21 family transposase -
EO087_RS03865 788710..789468 + 759 WP_128897459.1 IS21-like element helper ATPase IstB -
EO087_RS03870 789792..790358 - 567 WP_128897723.1 recombinase family protein -
EO087_RS03875 790364..790642 - 279 WP_205744469.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EO087_RS03880 790639..790833 - 195 WP_128897725.1 antitoxin Antitoxin
EO087_RS03885 790999..791994 + 996 WP_128897726.1 DUF4158 domain-containing protein -
EO087_RS03890 791951..792382 + 432 WP_128897727.1 IS200/IS605 family transposase -
EO087_RS03895 792471..792650 + 180 Protein_763 hypothetical protein -
EO087_RS03900 792764..793153 - 390 WP_128897728.1 cytochrome c -
EO087_RS03905 793301..794086 + 786 WP_128897729.1 tRNA threonylcarbamoyladenosine dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn - - 788710..792382 3672


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10374.84 Da        Isoelectric Point: 5.0367

>T117570 WP_205744469.1 NZ_CP035300:c790642-790364 [Dyella sp. M7H15-1]
MMLPVQWRASALDELDGVVAYIAQYNPAAADELHERIESSVLPLSEHPYLFRSGRVPGTREIVAHPNYIVVYRVLADCVE
IVNVVHASREYP

Download         Length: 279 bp

>T117570 NZ_CP035300:c790642-790364 [Dyella sp. M7H15-1]
CTGATGCTGCCGGTTCAGTGGCGCGCGTCGGCGCTGGATGAACTTGATGGTGTGGTCGCCTACATTGCGCAGTACAACCC
TGCTGCTGCCGACGAACTCCATGAGCGGATCGAATCCTCGGTACTGCCGTTATCCGAACATCCGTATTTGTTCCGGTCTG
GTCGAGTGCCCGGTACGCGCGAAATCGTCGCACACCCCAATTACATCGTGGTCTATCGCGTGCTTGCCGATTGCGTTGAA
ATCGTGAACGTAGTGCACGCATCACGCGAATATCCCTGA

Antitoxin


Download         Length: 65 a.a.        Molecular weight: 7297.30 Da        Isoelectric Point: 10.2690

>AT117570 WP_128897725.1 NZ_CP035300:c790833-790639 [Dyella sp. M7H15-1]
MKTKPLDPIVSEFATEEQAASYDRWFRAKVQASLDDPRPSVPHDEAMARIRATIDAAKRKQKRA

Download         Length: 195 bp

>AT117570 NZ_CP035300:c790833-790639 [Dyella sp. M7H15-1]
ATGAAGACCAAGCCGCTCGACCCGATCGTTTCCGAATTTGCCACGGAAGAACAGGCGGCCAGCTACGACCGCTGGTTCCG
TGCCAAGGTACAGGCCAGCCTGGACGATCCGCGTCCGAGCGTTCCGCACGATGAAGCCATGGCTCGTATTCGTGCAACCA
TCGATGCCGCTAAACGAAAGCAGAAGCGCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References