Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/upstrm_HI1419-dnstrm_HI1420
Location 436247..436839 Replicon chromosome
Accession NZ_CP035300
Organism Dyella sp. M7H15-1

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag EO087_RS02235 Protein ID WP_128897457.1
Coordinates 436546..436839 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag EO087_RS02230 Protein ID WP_128897456.1
Coordinates 436247..436531 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EO087_RS02205 432266..432748 - 483 WP_128897452.1 hypothetical protein -
EO087_RS02210 432928..433671 - 744 WP_128897453.1 hypothetical protein -
EO087_RS02215 433759..434424 - 666 WP_128897454.1 hypothetical protein -
EO087_RS02220 434486..435475 - 990 WP_205744413.1 hypothetical protein -
EO087_RS02225 435502..435891 - 390 WP_128897455.1 hypothetical protein -
EO087_RS16090 435994..436134 + 141 WP_164931738.1 hypothetical protein -
EO087_RS02230 436247..436531 - 285 WP_128897456.1 putative addiction module antidote protein Antitoxin
EO087_RS02235 436546..436839 - 294 WP_128897457.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EO087_RS02240 436921..437367 + 447 WP_128897458.1 lysozyme -
EO087_RS02250 437364..438620 - 1257 WP_205744414.1 recombinase zinc beta ribbon domain-containing protein -
EO087_RS02255 438726..439484 - 759 WP_128897459.1 IS21-like element helper ATPase IstB -
EO087_RS02260 439498..441066 - 1569 WP_128897460.1 IS21 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 430613..459366 28753
- flank IS/Tn - - 438726..439484 758


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-95)

Antitoxin

Uncharacterized protein HI1420

(3-91)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11088.68 Da        Isoelectric Point: 10.3911

>T117568 WP_128897457.1 NZ_CP035300:c436839-436546 [Dyella sp. M7H15-1]
MNTIHQTEEFKAWMRDLRDDTAKAKVITRTKQAAAGNFGDVKHFDGISEMRINYGSGYRVYYAKQGKTVYLLLIGGDKSS
QDRDIKKAQKLWKSIKG

Download         Length: 294 bp

>T117568 NZ_CP035300:c436839-436546 [Dyella sp. M7H15-1]
ATGAACACGATCCACCAAACTGAAGAATTCAAGGCATGGATGCGCGACCTTCGGGACGACACAGCGAAAGCCAAAGTCAT
CACAAGGACCAAACAAGCTGCAGCAGGAAACTTCGGCGACGTGAAGCATTTCGATGGCATCTCCGAGATGCGCATCAACT
ATGGATCGGGTTACCGCGTCTACTACGCCAAGCAGGGCAAAACGGTTTATCTGCTCTTGATTGGCGGAGACAAAAGCTCC
CAAGATCGCGACATCAAAAAAGCCCAGAAACTCTGGAAAAGCATCAAGGGGTAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10198.74 Da        Isoelectric Point: 5.6784

>AT117568 WP_128897456.1 NZ_CP035300:c436531-436247 [Dyella sp. M7H15-1]
MTTHITPFDAAEYLDNEKVIAAYIKEVMETGDYDLLLSALGDVAKARGMTDIAKASGLSRESLYKAVRPGSKPQYETVDR
IIHALGLKLTVAVA

Download         Length: 285 bp

>AT117568 NZ_CP035300:c436531-436247 [Dyella sp. M7H15-1]
ATGACCACCCACATCACACCTTTCGACGCCGCCGAATATCTGGACAACGAGAAAGTCATTGCCGCCTATATCAAAGAGGT
CATGGAGACCGGCGACTATGATCTATTGCTGTCCGCCCTTGGCGACGTTGCCAAGGCGCGCGGCATGACCGACATCGCCA
AAGCCTCCGGGCTCAGCCGCGAGAGCCTCTACAAGGCCGTACGACCGGGTTCAAAGCCGCAATACGAAACCGTGGATCGC
ATCATTCATGCGCTGGGCCTGAAGCTGACCGTAGCGGTCGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References