Detailed information of TA system TA117563

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YoeB(toxin)
• Location: 1658676..1659134
• Replicon: chromosome
• Accession: NZ_CP035298
• Organism: Micrococcus luteus strain ATCC 4698

Toxin (Protein)

• Gene name: relE
• Uniprot ID: C5CBH3
• Locus tag: ERB44_RS07955
• Protein ID: WP_010080486.1
• Coordinates: 1658880..1659134 (+)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: C5CBH4
• Locus tag: ERB44_RS07950
• Protein ID: WP_010080485.1
• Coordinates: 1658676..1658879 (+)
• Length: 68 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ERB44_RS07935 (ERB44_07935)	1655797..1656750	+	954	WP_141117318.1	hypothetical protein	-
ERB44_RS07940 (ERB44_07940)	1656806..1657135	-	330	Protein_1589	transposase	-
ERB44_RS07945 (ERB44_07945)	1657172..1658515	-	1344	WP_012751024.1	IS256-like element ISMlu11 family transposase	-
ERB44_RS07950 (ERB44_07950)	1658676..1658879	+	204	WP_010080485.1	antitoxin	Antitoxin
ERB44_RS07955 (ERB44_07955)	1658880..1659134	+	255	WP_010080486.1	Txe/YoeB family addiction module toxin	Toxin
ERB44_RS07960 (ERB44_07960)	1659136..1659702	+	567	WP_010080487.1	mismatch-specific DNA-glycosylase	-
ERB44_RS07965 (ERB44_07965)	1660012..1660794	-	783	WP_010080489.1	SCO1664 family protein	-
ERB44_RS07970 (ERB44_07970)	1660794..1661336	-	543	WP_010080490.1	DUF3090 domain-containing protein	-
ERB44_RS07975 (ERB44_07975)	1661333..1662058	-	726	WP_029248323.1	histidine phosphatase family protein	-
ERB44_RS12400	1662317..1662838	+	522	WP_010080493.1	hypothetical protein	-
ERB44_RS07985 (ERB44_07985)	1663047..1663703	+	657	WP_231936623.1	aquaporin Z	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (7-84)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 9795.09 Da
• Isoelectric Point: 6.7156

>T117563 WP_010080486.1 NZ_CP035298:1658880-1659134 [Micrococcus luteus]
MRLVSDRSAWDDCTHWQTTDRKVLQRINTLIDAALRDPLDGIGKPEQLKYGAAGAWSRRITEEHRLVYLVDGEDLIILQA
RYHY

Nucleotide

• Length: 255 bp

>T117563 NZ_CP035298:1658880-1659134 [Micrococcus luteus]
ATGCGCCTCGTGTCGGACCGCTCCGCCTGGGATGACTGCACGCACTGGCAGACCACGGACCGCAAGGTCCTCCAACGGAT
CAACACCCTCATCGACGCCGCCCTGCGTGATCCCCTCGACGGGATCGGCAAACCCGAGCAGCTGAAGTACGGCGCGGCCG
GGGCATGGTCCCGACGCATCACGGAGGAGCACAGGCTCGTCTACCTCGTCGACGGCGAGGACCTGATCATCCTCCAGGCG
AGGTATCACTACTGA

Antitoxin

Protein

• Length: 68 a.a.
• Molecular weight: 7374.33 Da
• Isoelectric Point: 4.5007

>AT117563 WP_010080485.1 NZ_CP035298:1658676-1658879 [Micrococcus luteus]
VPPEFDLADWYISRHHIAPEEAPMSISASEARKTLFPLIERVTADRDAVEIVSRKGNAVLMPADGDA

Nucleotide

• Length: 204 bp

>AT117563 NZ_CP035298:1658676-1658879 [Micrococcus luteus]
GTGCCTCCCGAGTTCGACCTCGCCGACTGGTACATAAGCAGGCACCACATCGCGCCGGAGGAGGCCCCCATGTCCATCAG
TGCCAGTGAAGCCCGCAAGACCCTGTTCCCGCTCATCGAGCGAGTGACTGCGGACCGCGACGCCGTCGAGATCGTCTCCC
GCAAGGGCAACGCCGTTCTCATGCCCGCGGACGGGGACGCCTGA

Structures

Toxin

• AlphaFold DB: C5CBH3

Antitoxin

• AlphaFold DB: C5CBH4