Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 973473..974279 Replicon chromosome
Accession NZ_CP035294
Organism Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305 = NCTC 7292 strain ATCC 15305

Toxin (Protein)


Gene name tsbT Uniprot ID Q49YQ0
Locus tag EQ030_RS04795 Protein ID WP_011302805.1
Coordinates 974094..974279 (+) Length 62 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID Q49YQ1
Locus tag EQ030_RS04790 Protein ID WP_011302804.1
Coordinates 973473..974072 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EQ030_RS04770 969352..970814 + 1463 Protein_915 ABC transporter substrate-binding protein/permease -
EQ030_RS04775 970807..971529 + 723 WP_002482873.1 amino acid ABC transporter ATP-binding protein -
EQ030_RS04780 971690..972817 + 1128 WP_011302803.1 tRNA epoxyqueuosine(34) reductase QueG -
EQ030_RS04785 972822..973292 + 471 WP_002482875.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
EQ030_RS04790 973473..974072 + 600 WP_011302804.1 glucosamine-6-phosphate isomerase Antitoxin
EQ030_RS04795 974094..974279 + 186 WP_011302805.1 hypothetical protein Toxin
EQ030_RS04800 974436..974852 + 417 WP_011302806.1 hypothetical protein -
EQ030_RS04805 975230..976615 + 1386 WP_011302807.1 class II fumarate hydratase -
EQ030_RS04810 976818..977645 - 828 WP_011302808.1 RluA family pseudouridine synthase -
EQ030_RS04815 977830..978945 + 1116 WP_011302809.1 GAF domain-containing sensor histidine kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(125-195)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 7056.51 Da        Isoelectric Point: 3.8237

>T117556 WP_011302805.1 NZ_CP035294:974094-974279 [Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305 = NCTC]
MSLDKNQNNLHRDELESENAMVDDLEDVVELGKEMEQISEENDEDKLDKSHDPAVRSDLNE

Download         Length: 186 bp

>T117556 NZ_CP035294:974094-974279 [Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305 = NCTC]
ATGAGTTTAGATAAAAATCAAAATAATCTACATCGTGATGAATTAGAGTCAGAAAACGCGATGGTTGATGATTTAGAGGA
TGTCGTAGAATTAGGAAAAGAAATGGAACAAATCTCTGAAGAAAATGATGAAGATAAATTAGATAAATCACATGACCCAG
CAGTACGTTCCGATTTAAATGAATAG

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22279.11 Da        Isoelectric Point: 4.8524

>AT117556 WP_011302804.1 NZ_CP035294:973473-974072 [Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305 = NCTC]
MAMNFKVLENEQVVAEYAADILRKQFNNNPTTIAGVHLSSDNAPVLDELKKNVDKHAVDFSQINILDYDNNKSYFEALGV
PEGQIFNVSFGEDTESFIKDKIKTKENKGKLITQVLSIDTNGKLDVSVNQGLFSAREVILIITGSDKKEVVHKLYEENGK
TSFEPSDLKAHRMVNVILDEAAAEGLPEDVRHYFTARFA

Download         Length: 600 bp

>AT117556 NZ_CP035294:973473-974072 [Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305 = NCTC]
ATGGCAATGAACTTTAAAGTTTTAGAAAATGAACAAGTTGTAGCGGAATATGCTGCAGATATCTTAAGAAAACAATTTAA
CAACAATCCAACAACAATTGCTGGCGTACACCTTTCAAGTGACAATGCACCAGTATTGGATGAATTAAAGAAAAATGTTG
ATAAACATGCAGTAGATTTTAGTCAAATTAATATTCTGGATTATGATAACAATAAATCATACTTTGAAGCACTTGGTGTT
CCAGAAGGCCAAATCTTCAATGTTTCATTTGGTGAAGATACGGAATCATTTATTAAAGATAAAATCAAAACTAAAGAAAA
TAAAGGGAAATTGATTACACAAGTACTTTCTATTGATACAAATGGTAAATTAGATGTAAGTGTGAATCAAGGTTTATTCT
CGGCACGTGAAGTTATTTTAATTATTACAGGTAGCGATAAAAAAGAAGTCGTTCATAAACTTTATGAAGAAAATGGTAAA
ACAAGTTTTGAACCTTCAGATTTAAAAGCGCACCGTATGGTTAATGTTATTTTAGATGAAGCGGCTGCTGAAGGTTTACC
AGAAGATGTTAGACATTATTTCACTGCACGTTTTGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A380HKL3

Antitoxin

Source ID Structure
AlphaFold DB Q49YQ1

References