Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 822562..823076 Replicon chromosome
Accession NZ_CP035294
Organism Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305 = NCTC 7292 strain ATCC 15305

Toxin (Protein)


Gene name TsdT Uniprot ID Q49Z34
Locus tag EQ030_RS03930 Protein ID WP_011302693.1
Coordinates 822870..823076 (+) Length 69 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID Q49Z35
Locus tag EQ030_RS03925 Protein ID WP_002482740.1
Coordinates 822562..822855 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EQ030_RS03900 817724..818515 + 792 WP_011302688.1 hydroxyethylthiazole kinase -
EQ030_RS03905 818515..819153 + 639 WP_011302689.1 thiamine phosphate synthase -
EQ030_RS03910 819241..820110 + 870 WP_011302690.1 membrane protein insertase YidC -
EQ030_RS03915 820192..820866 - 675 WP_170178158.1 HD domain-containing protein -
EQ030_RS03920 820935..822419 - 1485 WP_011302692.1 cardiolipin synthase -
EQ030_RS03925 822562..822855 + 294 WP_002482740.1 copper-sensing transcriptional repressor CsoR Antitoxin
EQ030_RS03930 822870..823076 + 207 WP_011302693.1 hypothetical protein Toxin
EQ030_RS03935 823289..823429 + 141 WP_002482742.1 hypothetical protein -
EQ030_RS03940 823722..824927 - 1206 WP_011302694.1 rod shape-determining protein RodA -
EQ030_RS03945 825176..826246 + 1071 WP_011302695.1 D-alanine--D-alanine ligase -
EQ030_RS03950 826259..827614 + 1356 WP_011302696.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Metal-sensitive transcriptional repressor

(4-95)


Sequences

Toxin        


Download         Length: 69 a.a.        Molecular weight: 8040.28 Da        Isoelectric Point: 4.3776

>T117554 WP_011302693.1 NZ_CP035294:822870-823076 [Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305 = NCTC]
MQSKVIYIAELYNEKQKLQIEERLMKLYGVFKVSTDIEEGAIFVDFETPANLNNLEKEVYDLGYKIIY

Download         Length: 207 bp

>T117554 NZ_CP035294:822870-823076 [Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305 = NCTC]
ATGCAATCAAAAGTTATTTATATTGCTGAACTTTATAATGAGAAGCAAAAATTACAAATTGAAGAAAGACTAATGAAACT
TTATGGTGTGTTTAAAGTTAGTACAGATATAGAAGAAGGCGCAATCTTTGTAGATTTTGAAACGCCTGCAAATTTGAATA
ATTTAGAAAAAGAAGTGTACGATTTAGGTTATAAAATAATTTATTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11221.90 Da        Isoelectric Point: 6.3282

>AT117554 WP_002482740.1 NZ_CP035294:822562-822855 [Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305 = NCTC]
MTEIQKAHHSEEIKANLKSRLNRIEGQVKAINRMVEEDVYCDDVLTQIRATRSALNSVATKLLDHHMKSCIMDKVEQGHE
QEAMEELLVTFQKLMKD

Download         Length: 294 bp

>AT117554 NZ_CP035294:822562-822855 [Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305 = NCTC]
ATGACTGAAATACAAAAAGCGCATCATTCAGAAGAAATAAAAGCAAATTTAAAATCAAGACTTAATAGAATCGAAGGTCA
AGTTAAAGCCATAAATCGTATGGTAGAGGAAGATGTGTACTGTGACGATGTGCTTACACAAATAAGAGCTACGCGATCCG
CATTAAATAGTGTCGCTACTAAATTATTAGATCATCATATGAAAAGTTGTATTATGGATAAAGTTGAACAGGGTCATGAA
CAAGAAGCGATGGAAGAACTACTTGTAACTTTTCAAAAATTGATGAAGGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q49Z34

Antitoxin

Source ID Structure
AlphaFold DB A0A380HKS9

References