Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 2004846..2005314 Replicon chromosome
Accession NZ_CP035291
Organism Staphylococcus haemolyticus strain ATCC 29970

Toxin (Protein)


Gene name TsaT Uniprot ID Q4L4Q4
Locus tag EQ029_RS09675 Protein ID WP_011276326.1
Coordinates 2005126..2005314 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID Q4L4Q5
Locus tag EQ029_RS09670 Protein ID WP_011276325.1
Coordinates 2004846..2005103 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EQ029_RS09635 2000022..2000747 - 726 WP_037558439.1 type I 3-dehydroquinate dehydratase -
EQ029_RS09640 2000910..2001332 + 423 WP_016931015.1 organic hydroperoxide resistance protein -
EQ029_RS09645 2001595..2002086 + 492 WP_011276321.1 GNAT family N-acetyltransferase -
EQ029_RS09650 2002218..2002835 + 618 WP_011276322.1 LysE/ArgO family amino acid transporter -
EQ029_RS09655 2003022..2003630 - 609 WP_011276323.1 phosphoglycerate mutase family protein -
EQ029_RS09660 2003858..2004100 + 243 WP_011276324.1 hypothetical protein -
EQ029_RS09665 2004092..2004295 - 204 WP_033079647.1 sterile alpha motif-like domain-containing protein -
EQ029_RS09670 2004846..2005103 + 258 WP_011276325.1 hypothetical protein Antitoxin
EQ029_RS09675 2005126..2005314 + 189 WP_011276326.1 hypothetical protein Toxin
EQ029_RS09680 2005432..2006013 + 582 WP_011276327.1 hypothetical protein -
EQ029_RS09685 2006061..2006297 - 237 WP_016931008.1 hypothetical protein -
EQ029_RS09690 2006467..2007213 + 747 WP_037558435.1 membrane lipoprotein lipid attachment site-containing protein -
EQ029_RS09695 2007282..2007890 - 609 WP_011276331.1 GNAT family N-acetyltransferase -
EQ029_RS09700 2008027..2008773 + 747 WP_011276332.1 poly-gamma-glutamate hydrolase family protein -
EQ029_RS09705 2008849..2009136 + 288 WP_011276333.1 hypothetical protein -
EQ029_RS09710 2009382..2009606 + 225 WP_011276334.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside SCCmec - clpP 1818002..2208165 390163


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7110.80 Da        Isoelectric Point: 9.6269

>T117550 WP_011276326.1 NZ_CP035291:2005126-2005314 [Staphylococcus haemolyticus]
MSLHLTILLWLGIIFVIAASIILGLLLKSKKEERKESYLGFTVIFYIFGFALLIYVFIFGIL

Download         Length: 189 bp

>T117550 NZ_CP035291:2005126-2005314 [Staphylococcus haemolyticus]
ATGAGTTTGCATTTAACTATATTGTTATGGCTTGGTATCATTTTTGTAATAGCAGCCTCAATTATATTGGGCTTATTACT
TAAATCTAAAAAAGAAGAACGTAAAGAATCATATTTAGGTTTTACCGTAATATTTTATATTTTTGGATTTGCTTTACTCA
TCTACGTATTCATATTTGGTATATTATAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9914.97 Da        Isoelectric Point: 4.0625

>AT117550 WP_011276325.1 NZ_CP035291:2004846-2005103 [Staphylococcus haemolyticus]
MNNNKIFWINIFMTLLFLGFNIIVTYNADLDDFFWLIPGLTISGITIVLSLSTALICKNLVSEVIFLINIVMLLYYIYPM
VYTFF

Download         Length: 258 bp

>AT117550 NZ_CP035291:2004846-2005103 [Staphylococcus haemolyticus]
ATGAATAATAATAAAATTTTTTGGATAAATATTTTTATGACGCTATTATTTTTGGGTTTCAATATCATTGTCACTTACAA
TGCAGACTTAGATGATTTCTTCTGGCTAATTCCAGGACTGACAATTAGTGGTATCACAATTGTACTAAGCTTAAGTACTG
CGCTCATTTGCAAGAACCTGGTTAGCGAAGTTATTTTTCTAATCAATATTGTTATGCTTTTATACTACATTTATCCTATG
GTATATACATTCTTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A1KAB5

Antitoxin

Source ID Structure
AlphaFold DB A0A2A1KAX9

References