Detailed information of TA system TA117549

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 1040301..1041072
• Replicon: chromosome
• Accession: NZ_CP035291
• Organism: Staphylococcus haemolyticus strain ATCC 29970

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: -
• Locus tag: EQ029_RS05090
• Protein ID: WP_011275410.1
• Coordinates: 1040923..1041072 (+)
• Length: 50 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: Q4L7F8
• Locus tag: EQ029_RS05085
• Protein ID: WP_011275409.1
• Coordinates: 1040301..1040900 (+)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EQ029_RS05065	1036184..1037638	+	1455	WP_053019944.1	ABC transporter substrate-binding protein/permease	-
EQ029_RS05070	1037631..1038353	+	723	WP_016931345.1	amino acid ABC transporter ATP-binding protein	-
EQ029_RS05075	1038531..1039658	+	1128	WP_011275407.1	tRNA epoxyqueuosine(34) reductase QueG	-
EQ029_RS05080	1039659..1040129	+	471	WP_016931343.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
EQ029_RS05085	1040301..1040900	+	600	WP_011275409.1	glucosamine-6-phosphate isomerase	Antitoxin
EQ029_RS05090	1040923..1041072	+	150	WP_011275410.1	hypothetical protein	Toxin
EQ029_RS05095	1041283..1041678	+	396	WP_057504773.1	hypothetical protein	-
EQ029_RS05100	1041885..1043270	+	1386	WP_011275412.1	class II fumarate hydratase	-
EQ029_RS05105	1043336..1044160	-	825	WP_011275413.1	RluA family pseudouridine synthase	-
EQ029_RS05110	1044348..1045457	+	1110	WP_011275414.1	GAF domain-containing sensor histidine kinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (130-195)

Sequences

Toxin

Protein

• Length: 50 a.a.
• Molecular weight: 5796.18 Da
• Isoelectric Point: 3.9484

>T117549 WP_011275410.1 NZ_CP035291:1040923-1041072 [Staphylococcus haemolyticus]
MTKNKDSELNYHEEENAMVQDLDDLKTLGKEMEQISEENDEDKLNQSHE

Nucleotide

• Length: 150 bp

>T117549 NZ_CP035291:1040923-1041072 [Staphylococcus haemolyticus]
ATGACTAAAAATAAAGATTCAGAATTAAATTATCATGAGGAAGAAAATGCGATGGTTCAAGATTTAGATGACTTGAAAAC
CTTGGGTAAAGAAATGGAACAAATTTCTGAAGAAAACGACGAGGACAAGTTGAATCAATCGCATGAGTAA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22272.12 Da
• Isoelectric Point: 4.7588

>AT117549 WP_011275409.1 NZ_CP035291:1040301-1040900 [Staphylococcus haemolyticus]
MAMNFKVFNDVEHVAEYTADIIRKQFNNNPTTIAGIHLTKDAAPVLDELKKDVDHNAVDFSQVNILDYDDNRSYYEALGV
PASQIYPINLDDDAESLIDDKIKTKENKGKLILQVTSIDESGSLNVNVRQGLLKAREVVLVVTGANKREVVKKLYEENGK
SSFEPSDLKAHRMVTVVLDRAAAEGLPEDVKEYFTARFA

Nucleotide

• Length: 600 bp

>AT117549 NZ_CP035291:1040301-1040900 [Staphylococcus haemolyticus]
ATGGCAATGAACTTTAAAGTATTTAATGATGTAGAACATGTAGCTGAGTACACAGCAGATATCATTAGAAAGCAATTTAA
TAATAACCCTACAACTATTGCGGGAATTCATTTAACAAAGGATGCTGCACCTGTTTTAGATGAGTTAAAGAAAGATGTAG
ATCATAATGCGGTTGATTTTAGTCAAGTAAATATCTTAGATTATGACGATAATCGCTCTTACTATGAAGCATTAGGTGTA
CCTGCTAGTCAAATTTATCCAATTAATCTTGACGATGATGCAGAATCTTTAATTGATGACAAAATTAAAACTAAAGAAAA
TAAAGGTAAATTAATTTTACAAGTTACTTCTATTGATGAATCAGGTAGTTTAAATGTAAATGTAAGACAAGGATTATTAA
AAGCGCGTGAAGTAGTATTAGTTGTGACTGGTGCTAATAAACGTGAAGTTGTTAAAAAACTTTATGAAGAAAATGGTAAA
TCTAGCTTTGAACCATCTGATTTAAAAGCTCATAGAATGGTAACAGTTGTTTTAGATAGAGCAGCTGCAGAAGGTTTACC
TGAGGATGTTAAAGAATATTTCACTGCTAGATTTGCTTAA

Structures

Antitoxin

• AlphaFold DB: A0A2A1K9C2