Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 894472..895004 Replicon chromosome
Accession NZ_CP035291
Organism Staphylococcus haemolyticus strain ATCC 29970

Toxin (Protein)


Gene name mazF Uniprot ID Q4L7V3
Locus tag EQ029_RS04265 Protein ID WP_011275272.1
Coordinates 894639..895004 (+) Length 122 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID Q4L7V4
Locus tag EQ029_RS04260 Protein ID WP_011275271.1
Coordinates 894472..894642 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EQ029_RS04235 890258..890737 + 480 WP_011275266.1 PH domain-containing protein -
EQ029_RS04240 890730..892253 + 1524 WP_016931363.1 PH domain-containing protein -
EQ029_RS04245 892246..892773 + 528 WP_016931364.1 PH domain-containing protein -
EQ029_RS04250 892783..893142 + 360 WP_037559766.1 holo-ACP synthase -
EQ029_RS04255 893238..894386 + 1149 WP_057504951.1 alanine racemase -
EQ029_RS04260 894472..894642 + 171 WP_011275271.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
EQ029_RS04265 894639..895004 + 366 WP_011275272.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
EQ029_RS04270 895312..896313 + 1002 WP_037559762.1 PP2C family protein-serine/threonine phosphatase -
EQ029_RS04275 896412..896738 + 327 WP_011275274.1 anti-sigma factor antagonist -
EQ029_RS04280 896740..897219 + 480 WP_011275275.1 anti-sigma B factor RsbW -
EQ029_RS04285 897194..897964 + 771 WP_011275276.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 13672.75 Da        Isoelectric Point: 8.4121

>T117548 WP_011275272.1 NZ_CP035291:894639-895004 [Staphylococcus haemolyticus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYRLDKDSVILLEQIR
TLDKKRLKEKLTYLSDEKMQEVDEALDISLGLHDEVKTQNT

Download         Length: 366 bp

>T117548 NZ_CP035291:894639-895004 [Staphylococcus haemolyticus]
ATGATTAGAAGAGGCGATGTATATTTAGCTGATTTGTCACCAGTACAGGGCTCAGAACAAGGGGGAGTCAGACCTGTAGT
TATCATTCAAAACGATACTGGTAACAAATATAGTCCTACCGTAATCGTTGCTGCGATTACGGGAAGGATTAATAAAGCGA
AAATACCCACACATGTTGAAATCGAGAAAAAGAAATACAGACTTGATAAAGATTCAGTTATTCTACTCGAGCAAATTAGA
ACATTAGATAAAAAACGACTAAAAGAAAAATTAACATATCTATCTGATGAGAAAATGCAAGAAGTGGATGAAGCGTTAGA
CATTAGTCTAGGATTGCATGATGAAGTTAAAACGCAAAACACATAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6380.08 Da        Isoelectric Point: 4.0325

>AT117548 WP_011275271.1 NZ_CP035291:894472-894642 [Staphylococcus haemolyticus]
MLTFNQNRSHSLEQSLKEGYAQMAELNLSLATEAFPLECEACDCNETYLISNYKSE

Download         Length: 171 bp

>AT117548 NZ_CP035291:894472-894642 [Staphylococcus haemolyticus]
ATGCTTACTTTCAATCAAAATAGAAGTCACAGTCTTGAACAATCTTTAAAAGAAGGCTATGCACAAATGGCCGAATTAAA
TCTCTCCCTAGCGACAGAAGCTTTTCCTCTAGAATGCGAAGCTTGTGATTGCAACGAAACGTACCTTATTTCTAATTATA
AAAGTGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A1KA75

Antitoxin

Source ID Structure
AlphaFold DB A0A2A1K7K7

References