Detailed information of TA system TA117547

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsdAT/-
• Location: 881547..882058
• Replicon: chromosome
• Accession: NZ_CP035291
• Organism: Staphylococcus haemolyticus strain ATCC 29970

Toxin (Protein)

• Gene name: TsdT
• Uniprot ID: Q4L7W7
• Locus tag: EQ029_RS04200
• Protein ID: WP_011275259.1
• Coordinates: 881852..882058 (+)
• Length: 69 a.a.

Antitoxin (Protein)

• Gene name: TsdA
• Uniprot ID: -
• Locus tag: EQ029_RS04195
• Protein ID: WP_011275258.1
• Coordinates: 881547..881840 (+)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EQ029_RS04175	876700..877575	+	876	WP_011275255.1	membrane protein insertase YidC	-
EQ029_RS04180	877770..879086	+	1317	WP_058646542.1	ISL3 family transposase	-
EQ029_RS04185	879135..879776	-	642	WP_016931420.1	HD domain-containing protein	-
EQ029_RS04190	879876..881360	-	1485	WP_011275257.1	cardiolipin synthase	-
EQ029_RS04195	881547..881840	+	294	WP_011275258.1	copper-sensing transcriptional repressor CsoR	Antitoxin
EQ029_RS04200	881852..882058	+	207	WP_011275259.1	heavy-metal-associated domain-containing protein	Toxin
EQ029_RS04205	882166..882303	+	138	WP_103261999.1	hypothetical protein	-
EQ029_RS04210	882600..884294	+	1695	WP_011275261.1	IS1182 family transposase	-
EQ029_RS04215	884252..885451	-	1200	WP_011275262.1	rod shape-determining protein RodA	-
EQ029_RS04220	885869..886939	+	1071	WP_057504952.1	D-alanine--D-alanine ligase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	IScluster/Tn	-	-	877770..884294	6524

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Metal-sensitive transcriptional repressor (3-95)

Sequences

Toxin

Protein

• Length: 69 a.a.
• Molecular weight: 7857.79 Da
• Isoelectric Point: 4.0742

>T117547 WP_011275259.1 NZ_CP035291:881852-882058 [Staphylococcus haemolyticus]
MNFSEIRISELNTEEQANSLQHRLEKMIGVDEVIVELNDQLVKISYETPTNLNSIEKEIYDDGYKVLG

Nucleotide

• Length: 207 bp

>T117547 NZ_CP035291:881852-882058 [Staphylococcus haemolyticus]
ATGAACTTTAGTGAAATTAGAATTAGTGAATTAAATACTGAAGAGCAAGCTAATTCACTCCAACATAGACTTGAGAAGAT
GATAGGTGTAGATGAAGTAATTGTAGAACTAAATGACCAATTAGTTAAAATTTCTTATGAAACACCTACGAATTTAAATA
GTATTGAAAAAGAAATTTATGATGATGGTTATAAGGTATTAGGTTGA

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 11222.83 Da
• Isoelectric Point: 6.6361

>AT117547 WP_011275258.1 NZ_CP035291:881547-881840 [Staphylococcus haemolyticus]
MNNHENAHHSDQIKMNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLDHHMKSCIMDKVNNGAQ
EEAMEELLVTFQKLMKD

Nucleotide

• Length: 294 bp

>AT117547 NZ_CP035291:881547-881840 [Staphylococcus haemolyticus]
TTGAATAATCATGAAAATGCACATCATTCCGATCAAATTAAAATGAATTTAAAATCAAGACTTAATCGTATTGAAGGGCA
AGTTAGAGCGATTAATCGCATGATTGAAGAAGATGTATACTGTGATGACGTGCTAACTCAAATTAGAGCTACAAGATCAG
CTTTAAATAGTGTGGCCACTAAGTTGCTAGATCATCATATGAAAAGCTGTATCATGGATAAAGTGAATAACGGCGCTCAA
GAAGAAGCGATGGAAGAATTGTTAGTGACTTTTCAAAAATTAATGAAAGATTAG

Structures

Toxin

• AlphaFold DB: A0A2A1K7I8